Publications
Detailed Information
AMPK-associated signaling to bridge the gap between fuel metabolism and hepatocyte viability
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Yoon Mee | - |
dc.contributor.author | Han, Chang Yeob | - |
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Kim, Sang Geon | - |
dc.date.accessioned | 2012-05-25T04:31:50Z | - |
dc.date.available | 2012-05-25T04:31:50Z | - |
dc.date.issued | 2010-08-14 | - |
dc.identifier.citation | WORLD JOURNAL OF GASTROENTEROLOGY; Vol.16 30; 3731-3742 | ko_KR |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76458 | - |
dc.description.abstract | The adenosine monophosphate-activated protein kinase (AMPK) and p70 ribosomal S6 kinase-1 pathway may serve as a key signaling flow that regulates energy metabolism; thus, this pathway becomes an attractive target for the treatment of liver diseases that result from metabolic derangements. In addition, AMPK emerges as a kinase that controls the redox-state and mitochondrial function, whose activity may be modulated by antioxidants. A close link exists between fuel metabolism and mitochondrial biogenesis. The relationship between fuel metabolism and cell survival strongly implies the existence of a shared signaling network, by which hepatocytes respond to challenges of external stimuli. The AMPK pathway may belong to this network. A series of drugs and therapeutic candidates enable hepatocytes to protect mitochondria from radical stress and increase cell viability, which may be associated with the activation of AMPK, liver kinase B1, and other molecules or components. Consequently, the components downstream of AMPK may contribute to stabilizing mitochondrial membrane potential for hepatocyte survival. In this review, we discuss the role of the AMPK pathway in hepatic energy metabolism and hepatocyte viability. This information may help identify ways to prevent and/or treat hepatic diseases caused by the metabolic syndrome. Moreover, clinical drugs and experimental therapeutic candidates that directly or indirectly modulate the AMPK pathway in distinct manners are discussed here with particular emphasis on their effects on fuel metabolism and mitochondrial function. (C) 2010 Baishideng. All rights reserved. | ko_KR |
dc.description.sponsorship | Supported by The National Research Foundation of Korea Grant,
Funded by the Korea Government (MEST), No. 2010-0001706, South Korea | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | W J G PRESS | ko_KR |
dc.subject | Adenosine monophosphate-activated protein kinase | ko_KR |
dc.subject | Cell survival | ko_KR |
dc.subject | Fatty liver | ko_KR |
dc.subject | p70 ribosomal S6 kinase-1 | ko_KR |
dc.subject | Glycogen synthase kinase 3 beta | ko_KR |
dc.subject | Insulin resistance | ko_KR |
dc.subject | Energy metabolism | ko_KR |
dc.title | AMPK-associated signaling to bridge the gap between fuel metabolism and hepatocyte viability | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 양윤미 | - |
dc.contributor.AlternativeAuthor | 한창엽 | - |
dc.contributor.AlternativeAuthor | 김윤준 | - |
dc.contributor.AlternativeAuthor | 김상건 | - |
dc.identifier.doi | 10.3748/wjg.v16.i30.3731 | - |
dc.citation.journaltitle | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.description.citedreference | Choi SH, 2010, BIOCHEM PHARMACOL, V79, P1352, DOI 10.1016/j.bcp.2009.12.011 | - |
dc.description.citedreference | Kim YW, 2010, FREE RADICAL BIO MED, V48, P567, DOI 10.1016/j.freeradbiomed.2009.12.006 | - |
dc.description.citedreference | Guo HX, 2009, ACTA PHARMACOL SIN, V30, P1505, DOI 10.1038/aps.2009.150 | - |
dc.description.citedreference | Shin SM, 2009, MOL PHARMACOL, V76, P884, DOI 10.1124/mol.109.058479 | - |
dc.description.citedreference | Kim YW, 2009, FREE RADICAL BIO MED, V47, P1082, DOI 10.1016/j.freeradbiomed.2009.07.018 | - |
dc.description.citedreference | Kewalramani G, 2009, CARDIOVASC RES, V84, P42, DOI 10.1093/cvr/cvp166 | - |
dc.description.citedreference | Spasic MR, 2009, NEUROSCIENTIST, V15, P309, DOI 10.1177/1073858408327805 | - |
dc.description.citedreference | Liesa M, 2009, PHYSIOL REV, V89, P799, DOI 10.1152/physrev.00030.2008 | - |
dc.description.citedreference | Gonzalez-Rodriguez A, 2009, HEPATOLOGY, V50, P216, DOI 10.1002/hep.22915 | - |
dc.description.citedreference | Hwahng SH, 2009, HEPATOLOGY, V49, P1913, DOI 10.1002/hep.22887 | - |
dc.description.citedreference | Kwon YN, 2009, DRUG METAB DISPOS, V37, P1187, DOI 10.1124/dmd.108.025908 | - |
dc.description.citedreference | Yuen DYC, 2009, DIABETES, V58, P1086, DOI 10.2337/db08-0775 | - |
dc.description.citedreference | Singh R, 2009, NATURE, V458, P1131, DOI 10.1038/nature07976 | - |
dc.description.citedreference | Herrero-Martin G, 2009, EMBO J, V28, P677, DOI 10.1038/emboj.2009.8 | - |
dc.description.citedreference | Huang Q, 2009, AUTOPHAGY, V5, P273, DOI 10.1038/cdd.2008.151 | - |
dc.description.citedreference | Vazquez-Chantada M, 2009, HEPATOLOGY, V49, P608, DOI 10.1002/hep.22660 | - |
dc.description.citedreference | He CC, 2009, ANNU REV GENET, V43, P67, DOI 10.1146/annurev-genet-102808-114910 | - |
dc.description.citedreference | Singh R, 2009, HEPATOLOGY, V49, P87, DOI 10.1002/hep.22578 | - |
dc.description.citedreference | Shin SM, 2009, MOL PHARMACOL, V75, P242, DOI 10.1124/mol.108.051128 | - |
dc.description.citedreference | Lage R, 2008, TRENDS MOL MED, V14, P539, DOI 10.1016/j.molmed.2008.09.007 | - |
dc.description.citedreference | Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024 | - |
dc.description.citedreference | Higuchi N, 2008, HEPATOL RES, V38, P1122, DOI 10.1111/j.1872-034X.2008.00382.x | - |
dc.description.citedreference | Das S, 2008, CIRC RES, V103, P983, DOI 10.1161/CIRCRESAHA.108.178970 | - |
dc.description.citedreference | Anderson N, 2008, PHARMACOL REV, V60, P311, DOI 10.1124/pr.108.00001 | - |
dc.description.citedreference | Hou XY, 2008, J BIOL CHEM, V283, P20015, DOI 10.1074/jbc.M802187200 | - |
dc.description.citedreference | Saberi B, 2008, AM J PHYSIOL-CELL PH, V295, pC50, DOI 10.1152/ajpcell.90654.2007 | - |
dc.description.citedreference | Bae EJ, 2008, MOL PHARMACOL, V73, P1502, DOI 10.1124/mol.107.044347 | - |
dc.description.citedreference | Fu XA, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002009 | - |
dc.description.citedreference | Mantena SK, 2008, FREE RADICAL BIO MED, V44, P1259, DOI 10.1016/j.freeradbiomed.2007.12.029 | - |
dc.description.citedreference | Hou N, 2008, ENDOCRINOLOGY, V149, P1654, DOI 10.1210/en.2007-0988 | - |
dc.description.citedreference | Xie Z, 2008, CIRCULATION, V117, P952, DOI 10.1161/CIRCULATIONAHA.107.744490 | - |
dc.description.citedreference | Marra F, 2008, TRENDS MOL MED, V14, P72, DOI 10.1016/j.molmed.2007.12.003 | - |
dc.description.citedreference | Wang HM, 2008, BIOCHEM PHARMACOL, V75, P457, DOI 10.1016/j.bcp.2007.08.028 | - |
dc.description.citedreference | Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538 | - |
dc.description.citedreference | Viollet B, 2007, DIABETES METAB, V33, P395, DOI 10.1016/j.diabet.2007.10.004 | - |
dc.description.citedreference | Milne JC, 2007, NATURE, V450, P712, DOI 10.1038/nature06261 | - |
dc.description.citedreference | Mizushima N, 2007, GENE DEV, V21, P2861, DOI 10.1101/gad.1599207 | - |
dc.description.citedreference | Kohjima M, 2007, INT J MOL MED, V20, P351 | - |
dc.description.citedreference | Bae EJ, 2007, HEPATOLOGY, V46, P730, DOI 10.1002/hep.21769 | - |
dc.description.citedreference | Ki SH, 2007, CHEM-BIOL INTERACT, V169, P80, DOI 10.1016/j.cbi.2007.05.008 | - |
dc.description.citedreference | Tremblay F, 2007, P NATL ACAD SCI USA, V104, P14056, DOI 10.1073/pnas.0706517104 | - |
dc.description.citedreference | Towler MC, 2007, CIRC RES, V100, P328, DOI 10.1161/01.RES.0000256090.42690.05 | - |
dc.description.citedreference | Gervois P, 2007, NAT CLIN PRACT ENDOC, V3, P145, DOI 10.1038/ncpendmet0397 | - |
dc.description.citedreference | Winder WW, 2007, CELL BIOCHEM BIOPHYS, V47, P332, DOI 10.1007/s12013-007-0008-7 | - |
dc.description.citedreference | OHORI K, 2007, J MOL CELL CARDIOL, V43, P564 | - |
dc.description.citedreference | Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354 | - |
dc.description.citedreference | Kockeritz L, 2006, CURR DRUG TARGETS, V7, P1377 | - |
dc.description.citedreference | Momcilovic M, 2006, J BIOL CHEM, V281, P25336, DOI 10.1074/jbc.M604399200 | - |
dc.description.citedreference | Tuncman G, 2006, P NATL ACAD SCI USA, V103, P10741, DOI 10.1073/pnas.06035009103 | - |
dc.description.citedreference | Kola B, 2006, TRENDS ENDOCRIN MET, V17, P205, DOI 10.1016/j.tem.2006.05.006 | - |
dc.description.citedreference | Um SH, 2006, CELL METAB, V3, P393, DOI 10.1016/j.cmet.2006.05.003 | - |
dc.description.citedreference | Park SS, 2006, J MOL CELL CARDIOL, V40, P708, DOI 10.1016/j.yjmcc.2006.01.024 | - |
dc.description.citedreference | Andreelli F, 2006, ENDOCRINOLOGY, V147, P2432, DOI 10.1210/en.2005-0898 | - |
dc.description.citedreference | Walker JW, 2006, BIOCHEM BIOPH RES CO, V342, P336, DOI 10.1016/j.bbrc.2006.01.145 | - |
dc.description.citedreference | Nawrocki AR, 2006, J BIOL CHEM, V281, P2654, DOI 10.1074/jbc.M505311200 | - |
dc.description.citedreference | Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781 | - |
dc.description.citedreference | Hamaguchi M, 2005, ANN INTERN MED, V143, P722 | - |
dc.description.citedreference | Codogno P, 2005, CELL DEATH DIFFER, V12, P1509, DOI 10.1038/sj.cdd.4401751 | - |
dc.description.citedreference | Terai K, 2005, MOL CELL BIOL, V25, P9554, DOI 10.1128/MCB.25.21.9554-9575.2005 | - |
dc.description.citedreference | Nakamuta M, 2005, INT J MOL MED, V16, P631 | - |
dc.description.citedreference | Tremblay F, 2005, DIABETES, V54, P2674 | - |
dc.description.citedreference | Holz MK, 2005, J BIOL CHEM, V280, P26089, DOI 10.1074/jbc.M504045200 | - |
dc.description.citedreference | Hawley SA, 2005, CELL METAB, V2, P9, DOI 10.1016/j.cmet.2005.05.009 | - |
dc.description.citedreference | Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI200523621 | - |
dc.description.citedreference | Foretz M, 2005, DIABETES, V54, P1331 | - |
dc.description.citedreference | Tamura S, 2005, J CLIN INVEST, V115, P1139, DOI 10.1172/JCI200524930 | - |
dc.description.citedreference | Wallace DC, 2005, ANNU REV GENET, V39, P359, DOI 10.1146/annurev.genet.39.110304.095751 | - |
dc.description.citedreference | Nakatani Y, 2004, J BIOL CHEM, V279, P45803, DOI 10.1074/jbc.M406963200 | - |
dc.description.citedreference | Um SH, 2004, NATURE, V431, P200, DOI 10.1038/nature02866 | - |
dc.description.citedreference | Szabadkai G, 2004, FEBS LETT, V567, P111, DOI 10.1016/j.febslet.2004.04.059 | - |
dc.description.citedreference | Ogihara T, 2004, DIABETOLOGIA, V47, P794, DOI 10.1007/s00125-004-1391-x | - |
dc.description.citedreference | Shaw RJ, 2004, P NATL ACAD SCI USA, V101, P3329, DOI 10.1073/pnas.0308061100 | - |
dc.description.citedreference | Piret JP, 2004, BIOCHEM PHARMACOL, V67, P611, DOI 10.1016/j.bcp.2003.09.026 | - |
dc.description.citedreference | Saha AK, 2004, BIOCHEM BIOPH RES CO, V314, P580, DOI 10.1016/j.bbrc.2003.12.120 | - |
dc.description.citedreference | Inoki K, 2003, CELL, V115, P577 | - |
dc.description.citedreference | Rotter V, 2003, J BIOL CHEM, V278, P45777, DOI 10.1074/jbc.M301977200 | - |
dc.description.citedreference | Woods A, 2003, CURR BIOL, V13, P2004, DOI 10.1016/j.cub.2003.10.031 | - |
dc.description.citedreference | Patti ME, 2003, P NATL ACAD SCI USA, V100, P8466, DOI 10.1073/pnas.1032913100 | - |
dc.description.citedreference | Orrenius S, 2003, NAT REV MOL CELL BIO, V4, P552, DOI 10.1038/nrm1150 | - |
dc.description.citedreference | Mootha VK, 2003, NAT GENET, V34, P267, DOI 10.1038/ng1180 | - |
dc.description.citedreference | Xu AM, 2003, J CLIN INVEST, V112, P91, DOI 10.1172/JCI200317797 | - |
dc.description.citedreference | Bajaj M, 2003, DIABETES, V52, P1364, DOI 10.2337/diabetes.52.6.1364 | - |
dc.description.citedreference | Petersen KF, 2003, SCIENCE, V300, P1140 | - |
dc.description.citedreference | Senn JJ, 2003, J BIOL CHEM, V278, P13740, DOI 10.1074/jbc.M210689200 | - |
dc.description.citedreference | Scorrano L, 2003, SCIENCE, V300, P135, DOI 10.1126/science.1081208 | - |
dc.description.citedreference | Fasshauer M, 2003, BIOCHEM BIOPH RES CO, V301, P1045, DOI 10.1016/S0006-291X(03)00090-1 | - |
dc.description.citedreference | Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137 | - |
dc.description.citedreference | Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788 | - |
dc.description.citedreference | Meisse D, 2002, FEBS LETT, V526, P38 | - |
dc.description.citedreference | Fryer LGD, 2002, J BIOL CHEM, V277, P25226, DOI 10.1074/jbc.M202489200 | - |
dc.description.citedreference | Liang GS, 2002, J BIOL CHEM, V277, P9520, DOI 10.1074/jbc.M111421200 | - |
dc.description.citedreference | Ido Y, 2002, DIABETES, V51, P159 | - |
dc.description.citedreference | Shikhman AR, 2001, J IMMUNOL, V167, P7001 | - |
dc.description.citedreference | Peralta C, 2001, HEPATOLOGY, V34, P1164, DOI 10.1053/jhep.2001.29197 | - |
dc.description.citedreference | Grimes CA, 2001, PROG NEUROBIOL, V65, P391 | - |
dc.description.citedreference | Zhou GC, 2001, J CLIN INVEST, V108, P1167 | - |
dc.description.citedreference | Marchesini G, 2001, LANCET, V358, P893 | - |
dc.description.citedreference | Sapkota GP, 2001, J BIOL CHEM, V276, P19469 | - |
dc.description.citedreference | Bergeron R, 2001, DIABETES, V50, P1076 | - |
dc.description.citedreference | TAKANO A, 2001, MOL CELL BIOL, V21, P5050 | - |
dc.description.citedreference | Repa JJ, 2000, GENE DEV, V14, P2819 | - |
dc.description.citedreference | Lin HZ, 2000, NAT MED, V6, P998 | - |
dc.description.citedreference | Hardin J, 2000, GUT, V47, P184, DOI 10.1136/gut.47.2.184 | - |
dc.description.citedreference | Peralta C, 2000, AM J PHYSIOL-GASTR L, V279, pG163 | - |
dc.description.citedreference | Aguirre V, 2000, J BIOL CHEM, V275, P9047 | - |
dc.description.citedreference | Collins SP, 2000, BIOCHEM J, V345, P673 | - |
dc.description.citedreference | Bradham CA, 1998, MOL CELL BIOL, V18, P6353 | - |
dc.description.citedreference | Stefanelli C, 1998, BIOCHEM BIOPH RES CO, V243, P821 | - |
dc.description.citedreference | Li P, 1997, CELL, V91, P479 | - |
dc.description.citedreference | Kantrow SP, 1997, BIOCHEM BIOPH RES CO, V232, P669 | - |
dc.description.citedreference | Marchetti P, 1996, J EXP MED, V184, P1155 | - |
dc.description.citedreference | Stouthard JML, 1996, BIOCHEM BIOPH RES CO, V220, P241 | - |
dc.description.citedreference | ZORATTI M, 1995, BBA-REV BIOMEMBRANES, V1241, P139 | - |
dc.description.citedreference | FRIDOVICH I, 1995, ANNU REV BIOCHEM, V64, P97 | - |
dc.description.citedreference | KRALL J, 1988, J BIOL CHEM, V263, P1910 | - |
dc.description.citedreference | DRYER SE, 1980, J BIOL CHEM, V255, P1054 | - |
dc.description.tc | 1 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.