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Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet`s disease susceptibility loci
Cited 401 time in
Web of Science
Cited 431 time in Scopus
- Authors
- Issue Date
- 2010-08
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- NATURE GENETICS; Vol.42 8; 703-U83
- Abstract
- Behçets disease is a chronic systemic inflammatory disorder
characterized by four major manifestations: recurrent
ocular symptoms, oral and genital ulcers and skin lesions1.
We conducted a genome-wide association study in a Japanese
cohort including 612 individuals with Behçets disease and
740 unaffected individuals (controls). We identified two
suggestive associations on chromosomes 1p31.3 (IL23R-IL12RB2,
rs12119179, P = 2.7 × 10−8) and 1q32.1 (IL10, rs1554286,
P = 8.0 × 10−8). A meta-analysis of these two loci with results
from additional Turkish and Korean cohorts showed genomewide
significant associations (rs1495965 in IL23R-IL12RB2,
P = 1.9 × 10−11, odds ratio = 1.35; rs1800871 in IL10, P = 1.0 ×
10−14, odds ratio = 1.45).
- ISSN
- 1061-4036
- Language
- English
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