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Association of SLC6A12 variants with aspirin-intolerant asthma in a Korean population
DC Field | Value | Language |
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dc.contributor.author | Pasaje, Charisse Flerida A. | - |
dc.contributor.author | Kim, Jeong-Hyun | - |
dc.contributor.author | Park, Byung-Lae | - |
dc.contributor.author | Cheong, Hyun Sub | - |
dc.contributor.author | Park, Tae-Joon | - |
dc.contributor.author | Kim, Yongha | - |
dc.contributor.author | Park, Jong Sook | - |
dc.contributor.author | Uh, Soo-Taek | - |
dc.contributor.author | Kim, Yong-Hoon | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.contributor.author | Choi, Byoung Whui | - |
dc.contributor.author | Cho, Sang Heon | - |
dc.contributor.author | Choi, Inseon S. | - |
dc.contributor.author | Kim, Mi-Kyeong | - |
dc.contributor.author | Choi, Jae-Sung | - |
dc.contributor.author | Yoon, Sang-Hyuk | - |
dc.contributor.author | Bae, Joon Seol | - |
dc.contributor.author | Lee, Jin-Sol | - |
dc.contributor.author | Chun, Ji-Yong | - |
dc.date.accessioned | 2012-05-25T07:11:12Z | - |
dc.date.available | 2012-05-25T07:11:12Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.citation | ANNALS OF HUMAN GENETICS; Vol.74 ; 326-334 | ko_KR |
dc.identifier.issn | 0003-4800 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76483 | - |
dc.description.abstract | Aspirin-intolerant asthma (AIA) occurs from asthma exacerbation after exposure to aspirin. However, the underlying mechanisms of AIA occurrence are still unclear. The critical role of the solute carrier family 6 (neurotransmitter transporter, betaine/GABA) member 12 (SLC6A12) gene in GABAergic transmission, which is associated with mucus production in asthma, makes it a candidate gene for AIA association study. Eight single nucleotide polymorphisms (SNPs) in SLC6A12 were genotyped in 163 aspirin-intolerant asthma (AIA) and 429 aspirin-tolerant asthma (ATA) patients of Korean ethnicity. Associations between polymorphisms of SLC6A12 and AIA were analysed using multivariate logistic analysis. Results showed that two polymorphisms and a haplotype in SLC6A12, rs499368 (P = 0.005; Pcorr = 0.03), rs557881 (non-synonymous C10R, P = 0.007; Pcorr = 0.04), and SLC6A12_BL1_ht1 (P = 0.009; Pcorr = 0.05) respectively, were significantly associated with AIA after multiple testing corrections. In addition, SNPs of SLC6A12 were significantly associated with the fall rate of FEV(1) by aspirin provocation suggesting that SLC6A12 could affect reversibility of lung function abnormalities in AIA patients. Although these results are preliminary and future replications are needed to confirm these findings, this study showed evidence of association between variants in SLC6A12 and AIA occurrence among asthmatics in a Korean population. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-BLACKWELL | ko_KR |
dc.subject | Aspirin-intolerant asthma | ko_KR |
dc.subject | polymorphism | ko_KR |
dc.subject | SLC6A12 | ko_KR |
dc.subject | haplotype | ko_KR |
dc.title | Association of SLC6A12 variants with aspirin-intolerant asthma in a Korean population | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김정현 | - |
dc.contributor.AlternativeAuthor | 박병래 | - |
dc.contributor.AlternativeAuthor | 정현섭 | - |
dc.contributor.AlternativeAuthor | 전지용 | - |
dc.contributor.AlternativeAuthor | 박태준 | - |
dc.contributor.AlternativeAuthor | 이진솔 | - |
dc.contributor.AlternativeAuthor | 김용하 | - |
dc.contributor.AlternativeAuthor | 배준설 | - |
dc.contributor.AlternativeAuthor | 박종숙 | - |
dc.contributor.AlternativeAuthor | 윤상혁 | - |
dc.contributor.AlternativeAuthor | 어수택 | - |
dc.contributor.AlternativeAuthor | 최재성 | - |
dc.contributor.AlternativeAuthor | 김용훈 | - |
dc.contributor.AlternativeAuthor | 김미경 | - |
dc.contributor.AlternativeAuthor | 최인선 | - |
dc.contributor.AlternativeAuthor | 조상헌 | - |
dc.contributor.AlternativeAuthor | 최병휘 | - |
dc.contributor.AlternativeAuthor | 박준식 | - |
dc.contributor.AlternativeAuthor | 신형두 | - |
dc.identifier.doi | 10.1111/j.1469-1809.2010.00584.x | - |
dc.citation.journaltitle | ANNALS OF HUMAN GENETICS | - |
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dc.description.tc | 8 | - |
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