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Identification of a Cholangiocarcinoma-Like Gene Expression Trait in Hepatocellular Carcinoma
DC Field | Value | Language |
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dc.contributor.author | Woo, Hyun Goo | - |
dc.contributor.author | Lee, Jeong-Hoon | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Kim, Chung Yong | - |
dc.contributor.author | Jang, Ja June | - |
dc.contributor.author | Suh, Kyung-Suk | - |
dc.contributor.author | Park, Eun Sung | - |
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Thorgeirsson, Snorri S. | - |
dc.contributor.author | Lee, Kuhn Uk | - |
dc.contributor.author | Yi, Nam-Joon | - |
dc.contributor.author | Lee, Hyo-Suk | - |
dc.date.accessioned | 2012-05-29T05:24:53Z | - |
dc.date.available | 2012-05-29T05:24:53Z | - |
dc.date.issued | 2010-04-15 | - |
dc.identifier.citation | CANCER RESEARCH; Vol.70 8; 3034-3041 | ko_KR |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76533 | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major adult liver cancers. The existence of combined hepatocellular-cholangiocarcinoma (CHC), a histopathologic intermediate form between HCC and CC, suggests phenotypic overlap between these tumors. Here, we applied an integrative oncogenomic approach to address the clinical and functional implications of the overlapping phenotype between these tumors. By performing gene expression profiling of human HCC, CHC, and CC, we identified a novel HCC subtype, i.e., cholangiocarcinoma-like HCC (CLHCC), which expressed cholangiocarcinoma-like traits (CC signature). Similar to CC and CHC, CLHCC showed an aggressive phenotype with shorter recurrence-free and overall survival. In addition, we found that CLHCC coexpressed embryonic stem cell-like expression traits (ES signature) suggesting its derivation from bipotent hepatic progenitor cells. By comparing the expression of CC signature with previous ES-like, hepatoblast-like, or proliferation-related traits, we observed that the prognostic value of the CC signatures was independent of the expression of those signatures. In conclusion, we suggest that the acquisition of cholangiocarcinoma-like expression traits plays a critical role in the heterogeneous progression of HCC. Cancer Res; 70(8); 3034-41. (C) 2010 AACR. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER ASSOC CANCER RESEARCH | ko_KR |
dc.title | Identification of a Cholangiocarcinoma-Like Gene Expression Trait in Hepatocellular Carcinoma | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 우현구 | - |
dc.contributor.AlternativeAuthor | 이정훈 | - |
dc.contributor.AlternativeAuthor | 윤정환 | - |
dc.contributor.AlternativeAuthor | 김정용 | - |
dc.contributor.AlternativeAuthor | 이효석 | - |
dc.contributor.AlternativeAuthor | 장재준 | - |
dc.contributor.AlternativeAuthor | 이남준 | - |
dc.contributor.AlternativeAuthor | 서경석 | - |
dc.contributor.AlternativeAuthor | 이건욱 | - |
dc.contributor.AlternativeAuthor | 박은성 | - |
dc.contributor.AlternativeAuthor | 김윤준 | - |
dc.identifier.doi | 10.1158/0008-5472.CAN-09-2823 | - |
dc.citation.journaltitle | CANCER RESEARCH | - |
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dc.description.tc | 6 | - |
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