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Clinical Features and Outcomes of Idiopathic Pulmonary Alveolar Proteinosis in Korean Population
DC Field | Value | Language |
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dc.contributor.author | Byun, Min Kwang | - |
dc.contributor.author | Kim, Dong Soon | - |
dc.contributor.author | Kim, Young Whan | - |
dc.contributor.author | Chung, Man Pyo | - |
dc.contributor.author | Cha, Seung Ick | - |
dc.contributor.author | Park, Choon Sik | - |
dc.contributor.author | Park, Yong Bum | - |
dc.contributor.author | Park, Moo Suk | - |
dc.contributor.author | Lee, Hong Lyeol | - |
dc.contributor.author | Jeong, Sung Hwan | - |
dc.contributor.author | Uh, Soo-Taek | - |
dc.contributor.author | Shim, Jae Jeong | - |
dc.date.accessioned | 2012-05-29T05:45:57Z | - |
dc.date.available | 2012-05-29T05:45:57Z | - |
dc.date.issued | 2010-03 | - |
dc.identifier.citation | JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.25 3; 393-398 | ko_KR |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76539 | - |
dc.description.abstract | Idiopathic pulmonary alveolar proteinosis (PAP) is a rare disorder in which lipoproteinaceous material accumulates within alveoli. There were few reports on Asian populations with idiopathic PAP. We retrospectively reviewed 38 patients with idiopathic PAP in Korea. We assessed clinical features, therapeutic efficacy and outcomes of whole lung lavage in patients with idiopathic PAP. The mean age at diagnosis was 52 yr. Eighty six percent of patients were symptomatic at diagnosis. Dyspnea and cough were the most common symptoms. Crackles were the most common physical examination finding. On pulmonary function test, a mild restrictive ventilatory defect was common, with a predicted mean forced vital capacity (FVC) of 77% and forced expiratory volume in one second (FEV(1)) of 84.6%. Diffusing capacity was disproportionately reduced at 67.7%. Arterial blood gas analysis revealed hypoxemia with a decreased PaO(2) of 69.0 mmHg and an increased D(A-a)O(2) of 34.2 mmHg. After whole lung lavage, PaO(2), D(A-a)O(2) and DL(CO) were significantly improved, but FVC and total lung capacity (TLC) were not different. This is the first multicenter study to analyze 38 Korean patients with idiopathic PAP. The clinical features and pulmonary parameters of Korean patients with idiopathic PAP are consistent with reports in other published studies. Whole lung lavage appears to be the most effective form of treatment. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | ko_KR |
dc.subject | Pulmonary Alveolar Proteinosis | ko_KR |
dc.subject | Treatment Outcome | ko_KR |
dc.subject | Irrigation | ko_KR |
dc.subject | Koreans | ko_KR |
dc.title | Clinical Features and Outcomes of Idiopathic Pulmonary Alveolar Proteinosis in Korean Population | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 변민광 | - |
dc.contributor.AlternativeAuthor | 김동순 | - |
dc.contributor.AlternativeAuthor | 김영환 | - |
dc.contributor.AlternativeAuthor | 정만표 | - |
dc.contributor.AlternativeAuthor | 심재정 | - |
dc.contributor.AlternativeAuthor | 차승익 | - |
dc.contributor.AlternativeAuthor | 우수택 | - |
dc.contributor.AlternativeAuthor | 박준식 | - |
dc.contributor.AlternativeAuthor | 정성환 | - |
dc.contributor.AlternativeAuthor | 박용범 | - |
dc.contributor.AlternativeAuthor | 이홍렬 | - |
dc.contributor.AlternativeAuthor | 박무석 | - |
dc.identifier.doi | 10.3346/jkms.2010.25.3.393 | - |
dc.citation.journaltitle | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
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dc.description.tc | 2 | - |
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