Publications
Detailed Information
Identification of MicroRNA-21 as a Biomarker for Chemoresistance and Clinical Outcome Following Adjuvant Therapy in Resectable Pancreatic Cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Jin-Hyeok | - |
dc.contributor.author | Voortman, Johannes | - |
dc.contributor.author | Giovannetti, Elisa | - |
dc.contributor.author | Steinberg, Seth M. | - |
dc.contributor.author | Kim, Yong-Tae | - |
dc.contributor.author | Park, Joo Kyung | - |
dc.contributor.author | Kang, Gyeong Hoon | - |
dc.contributor.author | Del Chiaro, Marco | - |
dc.contributor.author | Giaccone, Giuseppe | - |
dc.contributor.author | Peters, Godefridus J. | - |
dc.contributor.author | Kim, Sun-Whe | - |
dc.contributor.author | Kim, Min A. | - |
dc.contributor.author | Funel, Niccola | - |
dc.contributor.author | Leon, Leticia G. | - |
dc.date.accessioned | 2012-05-29T05:56:14Z | - |
dc.date.available | 2012-05-29T05:56:14Z | - |
dc.date.issued | 2010-05-14 | - |
dc.identifier.citation | PLOS ONE; Vol.5 5; e10630 | ko_KR |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76542 | - |
dc.description.abstract | Background: Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. The high risk of recurrence following surgical resection provides the rationale for adjuvant therapy. However, only a subset of patients benefit from adjuvant therapy. Identification of molecular markers to predict treatment outcome is therefore warranted. The aim of the present study was to evaluate whether expression of novel candidate biomarkers, including microRNAs, can predict clinical outcome in PDAC patients treated with adjuvant therapy. Methodology/Principal Findings: Formalin-fixed paraffin embedded specimens from a cohort of 82 resected Korean PDAC cases were analyzed for protein expression by immunohistochemistry and for microRNA expression using quantitative Real-Time PCR. Cox proportional hazards model analysis in the subgroup of patients treated with adjuvant therapy (N = 52) showed that lower than median miR-21 expression was associated with a significantly lower hazard ratio (HR) for death (HR = 0.316; 95% CI = 0.166-0.600; P = 0.0004) and recurrence (HR = 0.521; 95% CI = 0.280-0.967; P = 0.04). MiR-21 expression status emerged as the single most predictive biomarker for treatment outcome among all 27 biological and 9 clinicopathological factors evaluated. No significant association was detected in patients not treated with adjuvant therapy. In an independent validation cohort of 45 frozen PDAC tissues from Italian cases, all treated with adjuvant therapy, lower than median miR-21 expression was confirmed to be correlated with longer overall as well as disease-free survival. Furthermore, transfection with anti-miR-21 enhanced the chemosensitivity of PDAC cells. Conclusions Significance: Low miR-21 expression was associated with benefit from adjuvant treatment in two independent cohorts of PDAC cases, and anti-miR-21 increased anticancer drug activity in vitro. These data provide evidence that miR-21 may allow stratification for adjuvant therapy, and represents a new potential target for therapy in PDAC. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | PUBLIC LIBRARY SCIENCE | ko_KR |
dc.title | Identification of MicroRNA-21 as a Biomarker for Chemoresistance and Clinical Outcome Following Adjuvant Therapy in Resectable Pancreatic Cancer | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 황진혁 | - |
dc.contributor.AlternativeAuthor | 김용태 | - |
dc.contributor.AlternativeAuthor | 박주경 | - |
dc.contributor.AlternativeAuthor | 김민아 | - |
dc.contributor.AlternativeAuthor | 강경훈 | - |
dc.contributor.AlternativeAuthor | 김선회 | - |
dc.identifier.doi | 10.1371/journal.pone.0010630 | - |
dc.citation.journaltitle | PLOS ONE | - |
dc.description.citedreference | Greither T, 2010, INT J CANCER, V126, P73, DOI 10.1002/ijc.24687 | - |
dc.description.citedreference | Navon R, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0008003 | - |
dc.description.citedreference | Mardin W, 2009, ANN SURG ONCOL, V16, P3183, DOI 10.1245/s10434-009-0623-1 | - |
dc.description.citedreference | Park JK, 2009, PANCREAS, V38, pE190 | - |
dc.description.citedreference | Bourguignon LYW, 2009, J BIOL CHEM, V284, P26533, DOI 10.1074/jbc.M109.027466 | - |
dc.description.citedreference | Schetter AJ, 2009, CLIN CANCER RES, V15, P5878, DOI 10.1158/1078-0432.CCR-09-0627 | - |
dc.description.citedreference | Ji Q, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006816 | - |
dc.description.citedreference | Li Y, 2009, BRAIN RES, V1286, P13, DOI 10.1016/j.brainres.2009.06.053 | - |
dc.description.citedreference | Li YW, 2009, CANCER RES, V69, P6704, DOI 10.1158/0008-5472.CAN-09-1298 | - |
dc.description.citedreference | Torrisani J, 2009, HUM GENE THER, V20, P831, DOI 10.1089/hum.2008.134 | - |
dc.description.citedreference | Jemal A, 2009, CA-CANCER J CLIN, V59, P225, DOI 10.3322/caac.20006 | - |
dc.description.citedreference | Garzon R, 2009, BLOOD, V113, P6411, DOI 10.1182/blood-2008-07-170589 | - |
dc.description.citedreference | Li T, 2009, BIOCHEM BIOPH RES CO, V383, P280, DOI 10.1016/j.bbrc.2009.03.077 | - |
dc.description.citedreference | Moriyama T, 2009, MOL CANCER THER, V8, P1067, DOI 10.1158/1535-7163.MCT-08-0592 | - |
dc.description.citedreference | Selaru FM, 2009, HEPATOLOGY, V49, P1595, DOI 10.1002/hep.22838 | - |
dc.description.citedreference | Glud M, 2009, J INVEST DERMATOL, V129, P1219, DOI 10.1038/jid.2008.347 | - |
dc.description.citedreference | Salek C, 2009, ANTICANCER RES, V29, P1803 | - |
dc.description.citedreference | Habbe N, 2009, CANCER BIOL THER, V8, P340 | - |
dc.description.citedreference | Garzon R, 2009, ANNU REV MED, V60, P167, DOI 10.1146/annurev.med.59.053006.104707 | - |
dc.description.citedreference | NEOPTOLEMOS J, 2009, J CLIN ONCOL, V27 | - |
dc.description.citedreference | Fujita Y, 2008, BIOCHEM BIOPH RES CO, V377, P114, DOI 10.1016/j.bbrc.2008.09.086 | - |
dc.description.citedreference | Sorrentino A, 2008, GYNECOL ONCOL, V111, P478, DOI 10.1016/j.ygyno.2008.08.017 | - |
dc.description.citedreference | Dillhoff M, 2008, J GASTROINTEST SURG, V12, P2171, DOI 10.1007/s11605-008-0584-x | - |
dc.description.citedreference | Leon LG, 2008, CHEMMEDCHEM, V3, P1740, DOI 10.1002/cmdc.200800212 | - |
dc.description.citedreference | Marchesi F, 2008, CANCER RES, V68, P9060, DOI 10.1158/0008-5472.CAN-08-1810 | - |
dc.description.citedreference | Jones S, 2008, SCIENCE, V321, P1801, DOI 10.1126/science.1164368 | - |
dc.description.citedreference | Lodygin D, 2008, CELL CYCLE, V7, P2591 | - |
dc.description.citedreference | Lu Z, 2008, ONCOGENE, V27, P4373, DOI 10.1038/onc.2008.72 | - |
dc.description.citedreference | Funel N, 2008, LAB INVEST, V88, P773, DOI 10.1038/labinvest.2008.40 | - |
dc.description.citedreference | Zhang WM, 2008, ELECTROCHEM COMMUN, V10, P519, DOI 10.1016/j.elecom.2008.01.032 | - |
dc.description.citedreference | Abbruzzese JL, 2008, JAMA-J AM MED ASSOC, V299, P1066 | - |
dc.description.citedreference | Katz MHG, 2008, CA-CANCER J CLIN, V58, P111, DOI 10.3322/CA.2007.0012 | - |
dc.description.citedreference | Zuckerman DS, 2008, CANCER, V112, P243, DOI 10.1002/cncr.23174 | - |
dc.description.citedreference | NEUHAUS P, 2008, J CLIN ONCOL, V26 | - |
dc.description.citedreference | Shah AN, 2007, ANN SURG ONCOL, V14, P3629, DOI 10.1245/s10434-007-9583-5 | - |
dc.description.citedreference | Tonini G, 2007, EXPERT OPIN THER TAR, V11, P1553, DOI 10.1517/14728222.11.12.1553 | - |
dc.description.citedreference | Gironella M, 2007, P NATL ACAD SCI USA, V104, P16170, DOI 10.1073/pnas.0703942104 | - |
dc.description.citedreference | Xi YG, 2007, RNA, V13, P1668, DOI 10.1261/rna.642907 | - |
dc.description.citedreference | Corsten MF, 2007, CANCER RES, V67, P8994, DOI 10.1158/0008-5472.CAN-07-1045 | - |
dc.description.citedreference | Meng FY, 2007, GASTROENTEROLOGY, V133, P647, DOI 10.1053/j.gastro.2007.05.022 | - |
dc.description.citedreference | Li JH, 2007, BMC BIOTECHNOL, V7, DOI 10.1186/1472-6750-7-36 | - |
dc.description.citedreference | He L, 2007, NATURE, V447, P1130, DOI 10.1038/nature05939 | - |
dc.description.citedreference | Si ML, 2007, ONCOGENE, V26, P2799, DOI 10.1038/sj.onc.1210083 | - |
dc.description.citedreference | Hampton T, 2007, JAMA-J AM MED ASSOC, V297, P937 | - |
dc.description.citedreference | Oettle H, 2007, JAMA-J AM MED ASSOC, V297, P267 | - |
dc.description.citedreference | Boeck S, 2007, ONCOLOGY-BASEL, V72, P314, DOI 10.1159/000113054 | - |
dc.description.citedreference | Bianco C, 2006, CLIN CANCER RES, V12, P7099, DOI 10.1158/1078-0432.CCR-06-0833 | - |
dc.description.citedreference | Roldo C, 2006, J CLIN ONCOL, V24, P4677, DOI 10.1200/JCO.2005.05.5194 | - |
dc.description.citedreference | Chadha KS, 2006, ANN SURG ONCOL, V13, P933, DOI 10.1245/ASO.2006.07.011 | - |
dc.description.citedreference | Meng FY, 2006, GASTROENTEROLOGY, V130, P2113, DOI 10.1053/j.gastro.2006.02.057 | - |
dc.description.citedreference | Giovannetti E, 2006, CANCER RES, V66, P3928, DOI 10.1158/0008-5472.CAN-05-4203 | - |
dc.description.citedreference | Jimeno A, 2006, MOL CANCER THER, V5, P787, DOI 10.1158/1535-7163.MCT-06-0005 | - |
dc.description.citedreference | Garcea G, 2005, EUR J CANCER, V41, P2213, DOI 10.1016/j.ejca.2005.04.044 | - |
dc.description.citedreference | Lu J, 2005, NATURE, V435, P834, DOI 10.1038/nature03702 | - |
dc.description.citedreference | Yamamoto S, 2004, CLIN CANCER RES, V10, P2846 | - |
dc.description.citedreference | Bartel DP, 2004, CELL, V116, P281 | - |
dc.description.citedreference | HE L, 2004, NAT REV GENET, V5, P522 | - |
dc.description.citedreference | Hruban RH, 2001, CANCER J, V7, P251 | - |
dc.description.citedreference | Sener SF, 1999, J AM COLL SURGEONS, V189, P1 | - |
dc.description.citedreference | Yeo CJ, 1997, ANN SURG, V226, P248 | - |
dc.description.citedreference | Itakura J, 1997, CLIN CANCER RES, V3, P1309 | - |
dc.description.citedreference | MEHTA CR, 1983, J AM STAT ASSOC, V78, P427 | - |
dc.description.citedreference | COX DR, 1972, J ROY STAT SOC B, V34, P187 | - |
dc.description.citedreference | MANTEL N, 1966, CANCER CHEMOTHERAPY, V50, P163 | - |
dc.description.citedreference | KAPLAN EL, 1958, JAMA-J AM MED ASSOC, V457, P481 | - |
dc.description.tc | 38 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.