Browse

Impacts of Vaccination on Hepatitis B Viral Infections in Korea over a 25-Year Period

Cited 54 time in Web of Science Cited 55 time in Scopus
Authors
Park, Neung Hwa; Chung, Young-Hwa; Lee, Hyo-Suk
Issue Date
2010
Publisher
KARGER
Citation
INTERVIROLOGY; Vol.53 1; 20-28
Keywords
EpidemiologyHepatitis B vaccineKoreaHepatitis B virus
Abstract
Background: Hepatitis B virus (HBV) vaccination has effectively reduced the acute and chronic infection rates in recent years. Since 1983, HBV vaccination has been recommended for all neonates in Korea. Methods: This article reviews the impacts of HBV vaccination throughout the past 25 years in Korea. Before the introduction of the HBV vaccination program, approximately 8% of the general Korean population tested positive for hepatitis B virus surface antigen (HBsAg). Results: The percentage of vaccinated infants has surpassed 98.9% since 1990. The HBsAg carrier rate in the general population decreased to 3.7% in 2007. In particular, the prevalence of HBsAg decreased to 0.44% in teenagers and to 0.2% in children younger than 10 years. In addition, administration of the HBV vaccine may have reduced the risk of hepatocellular carcinoma among adults. Despite the administration of hepatitis B immunoglobulin and the HBV vaccine to children with HBsAg-positive mothers, the failure rate of HBV immunoprophylaxis was 4.2% in 2008. In Korea, there have been no reported cases of HBV surface gene variants such as G145R. Conclusions: The prevalence of HBV carriers in Korea was markedly reduced after the introduction of the universal HBV vaccination program. Korea is now classified as an area of intermediate endemicity for HBV. Copyright (C) 2010 S. Karger AG, Basel
ISSN
0300-5526
Language
English
URI
http://hdl.handle.net/10371/76562
DOI
https://doi.org/10.1159/000252780
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse