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Coronary atherosclerosis detected by coronary CT angiography in asymptomatic subjects with early chronic kidney disease

Cited 35 time in Web of Science Cited 37 time in Scopus
Authors
Cho, Iksung; Min, Hee-Suk; Chun, Eun Ju; Park, Sue K.; Blumenthal, Roger S.; Nasir, Khurram; Sohn, Dae-Won; Park, Young-Bae; Chang, Hyuk-Jae; Oh, Byung-Hee; Kim, Yong-Jin; Rivera, Juan J.; Choi, Yunhee
Issue Date
2010-02
Publisher
ELSEVIER IRELAND LTD
Citation
ATHEROSCLEROSIS; Vol.208 2; 406-411
Keywords
Coronary atherosclerosisChronic kidney diseaseCoronary CT angiographyCoronary artery calcium scoreProteinuria
Abstract
Objectives: The purpose of this study is to assess the independent association between early CKD (stages 1-3a) with coronary atherosclerosis and the feasibility of risk stratification of coronary atherosclerosis according to The Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines using non-invasive coronary angiography. Methods: We consecutively enrolled 4297 asymptomatic subjects who underwent coronary CT angiography as part of a general health evaluation and had estimated glomerular filtration rates (eGFR) over 45 ml/min/1.73m(2). Subjects were categorized from no CKD to stage 3a CKD, and multiple regression analyses for coronary atherosclerosis were performed. Results: Early CKD was an independent risk factor for coronary artery disease (CAD) and obstructive CAD. However, neither the risk of CAD nor CACS > 100 increased as stage of CKD advanced. The reason for unsuccessful stratification of coronary atherosclerosis risk was that the presence of proteinuria, which was used to define stages 1 and 2 CKD, was an independent risk factor for coronary atherosclerosis, but eGFR of 45-89 ml/min/1.73m(2) was not associated with coronary atherosclerosis. Conclusions: Early CKD was an independent risk factor for coronary atherosclerosis, and the risk stratification for coronary atherosclerosis should be based on the presence of proteinuria rather than decreased eGFR within early CKD. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
ISSN
0021-9150
Language
English
URI
http://hdl.handle.net/10371/76569
DOI
https://doi.org/10.1016/j.atherosclerosis.2009.08.040
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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