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4기 유방암에서 원발 종양의 수술적 제거가 생존에 미치는 영향
The Impact of Primary Tumor Resection on the Survival of Patients with Stage IV Breast Cancer

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Authors
안수경; 한원식; 문형곤; 유종한; 고은영; 배진혜; 민준원; 김태유; 임석아; 오도연; 한세원; 하성환; 지의규; 오승근; 윤여규; 김성원; 황기태; 노동영
Issue Date
2010-03
Publisher
KOREAN BREAST CANCER SOC
Citation
JOURNAL OF BREAST CANCER; Vol.13 1; 90-95
Keywords
Breast neoplasmsSurvivalSurgeryStage IVNeoplasm metastasis유방암암 전이4기수술생존
Abstract
Purpose The main treatment for stage IV breast cancer is currently systemic therapy. Surgical resection of the primary tumor is usually done for treating the tumor-related complications Recent studies have suggested that surgery may improve the long-term survival of stage IV breast cancer patients We evaluated the impact of the primary surgical resection site on the survival of stage IV breast cancer patients. Methods We reviewed the records of the stage IV breast cancer patients who were treated at Seoul University Hospital between April 1992 and December 2007 The tumor and clinical characteristics, the type of treatments and the overall survival were compared between the surgically versus nonsurgically treated patients. Results. Of the 198 identified patients, 110 (55 8%) received surgical excision of their primary tumor and 88 (44 2%) did not The mean survival was 67 months vs. 42 months for the surgically treated patients vs the patients without surgery, respectively (p=0 0287) On a multivariate analysis with using the Cox model and after adjusting for the estrogen receptor status, visceral metastases, the number of metastatic sites and trastuzumab treatment, surgery was an independent factor for improved survival (hazard ratio, 0.55; 95% confidence interval, 0.31-0.97; p=0.041). Conclusion Surgical resection of the primary tumor in stage IV breast cancer patients was independently associated with improved survival. Randomized prospective trials are needed to firmly recommend surgical resection of the primary tumor in stage IV breast cancer patients
ISSN
1738-6756
Language
Korean
URI
http://hdl.handle.net/10371/76598
DOI
https://doi.org/10.4048/jbc.2010.13.1.90
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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