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Pre-S2 deletion mutants of hepatitis B virus could have an important role in hepatocarcinogenesis in Asian children
DC Field | Value | Language |
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dc.contributor.author | Abe, Kenji | - |
dc.contributor.author | Thung, Swan N. | - |
dc.contributor.author | Wu, Han-Chieh | - |
dc.contributor.author | Tran, Tung Thanh | - |
dc.contributor.author | Truong, Khai Dinh | - |
dc.contributor.author | Jang, Ja June | - |
dc.contributor.author | Su, Ih-Jen | - |
dc.contributor.author | Inui, Ayano | - |
dc.contributor.author | Hoang, Phuc Le | - |
dc.date.accessioned | 2012-05-30T01:33:47Z | - |
dc.date.available | 2012-05-30T01:33:47Z | - |
dc.date.issued | 2009-12 | - |
dc.identifier.citation | CANCER SCIENCE; Vol.100 12; 2249-2254 | ko_KR |
dc.identifier.issn | 1347-9032 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76602 | - |
dc.description.abstract | Although many studies on the risk factors and their carcinogenesis in adult hepatocellular carcinoma (HCC) have been reported, they remain poorly understood in childhood HCC. A retrospective study of 42 HCC cases in Asian children was conducted. Hepatitis B virus (HBV)-DNA in HCC tissues was detected in 36 of 42 (86%) cases tested, while no hepatitis C virus (HCV)-RNA was detectable in any of HCCs. Twenty of 36 (56%) HCC cases were accompanied by cirrhosis. Surprisingly, very high prevalence of the HBV pre-S deletion mutant was recognized in 27 of 30 (90%) HCCs examined. They occurred most frequently in pre-S2 (20/27, 74%) followed by pre-S1 (5/27, 18.5%), and both pre-S1/S2 (2/27, 7.4%). Interestingly, the pre-S2 mutant consistently appeared with deletion at nt 4-57 in all of the 20 cases with the pre-S2 mutant (100%) and within this locus in the two cases with both pre-S-1/S2 mutants. Type II ground-glass hepatocytes in non-tumorous livers were seen in 15 of the 22 HCCs with the pre-S2 deletion mutant (68%). This hotspot mutation in the pre-S2 was further confirmed by complete genomic sequence of HBV in a Japanese boy who eventually developed HCC. Our result strongly suggests that HBV is a major contributor to the development of HCC in Asian children. The HBV pre-S2 deletion mutant at nt 4-57 which has a CD8 T-cell epitope could be responsible for the emergence and aggressive outcome of childhood HCC. Determination of this hotspot mutation in the pre-S2 region could be a useful index for predicting the clinical outcome of HCC development. (Cancer Sci 2009; 100: 2249-2254). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-BLACKWELL PUBLISHING, INC | ko_KR |
dc.title | Pre-S2 deletion mutants of hepatitis B virus could have an important role in hepatocarcinogenesis in Asian children | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 장자준 | - |
dc.identifier.doi | 10.1111/j.1349-7006.2009.01309.x | - |
dc.citation.journaltitle | CANCER SCIENCE | - |
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