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Definitive Radiotherapy With or Without Chemotherapy for T3-4N0 Squamous Cell Carcinoma of the Maxillary Sinus and Nasal Cavity
DC Field | Value | Language |
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dc.contributor.author | Jang, Na Young | - |
dc.contributor.author | Wu, Hong-Gyun | - |
dc.contributor.author | Park, Charn Il | - |
dc.contributor.author | Heo, Dae-Seog | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Lee, Se-Hoon | - |
dc.contributor.author | Rhee, Chae-Seo | - |
dc.date.accessioned | 2012-05-30T02:40:49Z | - |
dc.date.available | 2012-05-30T02:40:49Z | - |
dc.date.created | 2020-04-08 | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | Japanese Journal of Clinical Oncology, Vol.40 No.6, pp.542-548 | - |
dc.identifier.issn | 0368-2811 | - |
dc.identifier.other | 95274 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76613 | - |
dc.description.abstract | Objective: To evaluate the efficacy and toxicity of definitive radiotherapy with or without chemotherapy for T3-4 squamous cell carcinoma of maxillary sinus and nasal cavity. Methods: Forty-two patients with T3-4N0 squamous cell carcinoma of maxillary sinus (n = 30) and nasal cavity (n = 12) received definitive radiotherapy. Chemotherapy was used in 34 patients and elective neck irradiation was not used. Results: The 5-year overall survival/local control rates were 34%/29% for maxillary sinus cancer and 50%/52% for nasal cavity cancer. For maxillary sinus cancers, a performance status of Eastern Cooperative Oncology Group >= 2 (P = 0.012), biologically equivalent dose <68 Gy (P = 0.011) and no use of chemotherapy (P = 0.037) were significant worse predictors for overall survival on log-rank analysis. Biologically equivalent dose <68 Gy was independently associated with poor local control (hazard ratio, 3.32; 95% confidence interval, 1.38-7.97; P = 0.007) and overall survival (hazard ratio, 2.94; 95% confidence interval, 1.23-7.01; P = 0.015). Regional recurrence occurred in only 1 of 30 patients with maxillary sinus cancer and 4 of 12 patients with nasal cavity. Two radiation necrosis in brain, one osteoradionecrosis, and one retinopathy and optic neuropathy occurred. Conclusions: The treatment outcome was poor and local control was a major problem. High radiation dose, effective chemotherapy and elective neck irradiation for advanced nasal cavity cancers may improve disease control. | - |
dc.language | 영어 | - |
dc.language.iso | en | ko_KR |
dc.publisher | Oxford University Press | - |
dc.title | Definitive Radiotherapy With or Without Chemotherapy for T3-4N0 Squamous Cell Carcinoma of the Maxillary Sinus and Nasal Cavity | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 박찬일 | - |
dc.contributor.AlternativeAuthor | 김동완 | - |
dc.contributor.AlternativeAuthor | 우홍균 | - |
dc.contributor.AlternativeAuthor | 이재서 | - |
dc.contributor.AlternativeAuthor | 허대석 | - |
dc.identifier.doi | 10.1093/jjco/hyq009 | - |
dc.citation.journaltitle | Japanese Journal of Clinical Oncology | - |
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dc.description.tc | 1 | - |
dc.identifier.wosid | 000278819500008 | - |
dc.identifier.scopusid | 2-s2.0-77953420448 | - |
dc.citation.endpage | 548 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 542 | - |
dc.citation.volume | 40 | - |
dc.identifier.sci | 000278819500008 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Wu, Hong-Gyun | - |
dc.contributor.affiliatedAuthor | Park, Charn Il | - |
dc.contributor.affiliatedAuthor | Heo, Dae-Seog | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Rhee, Chae-Seo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PARANASAL SINUSES | - |
dc.subject.keywordPlus | RADIATION-THERAPY | - |
dc.subject.keywordPlus | NODE METASTASIS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | ANTRUM | - |
dc.subject.keywordPlus | NOSE | - |
dc.subject.keywordAuthor | maxillary sinus cancer | - |
dc.subject.keywordAuthor | nasal cavity cancer | - |
dc.subject.keywordAuthor | squamous cell carcinoma | - |
dc.subject.keywordAuthor | radiotherapy | - |
dc.subject.keywordAuthor | chemotherapy | - |
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