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Leukemia-specific siRNA delivery by immunonanoplexes consisting of anti-JL1 minibody conjugated to oligo-9 Arg-peptides

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dc.contributor.authorLee, Yeon Kyung-
dc.contributor.authorKim, Keun Sik-
dc.contributor.authorKim, Jung Seok-
dc.contributor.authorBaek, Jin Ee-
dc.contributor.authorJeong, Hwa Yeon-
dc.contributor.authorJung, Kyeong Cheon-
dc.contributor.authorPark, Yong Serk-
dc.contributor.authorSong, Hyung Geun-
dc.contributor.authorYoon, Sang Soon-
dc.contributor.authorPark, Sang Il-
dc.date.accessioned2012-05-31T05:28:00Z-
dc.date.available2012-05-31T05:28:00Z-
dc.date.issued2010-05-
dc.identifier.citationMOLECULES AND CELLS; Vol.29 5; 457-462ko_KR
dc.identifier.issn1016-8478-
dc.identifier.urihttps://hdl.handle.net/10371/76675-
dc.description.abstractTargeted mRNA degradation by short interfering RNAs (siRNAs) offers a great potential to treat cancers. siRNA therapeutics for leukemias are, however, hindered by poor intracellular uptake, limited blood stability and nonspecific delivery. To solve these problems, we developed an anti-JL1 immunonanoplex (antibody-coupled nanocomplex) for siRNA delivery using anti-JL1 minibody (leukemia cell-specific minibody) conjugated to oligo-9-Arg peptide (9R) for effective siRNA delivery to leukemic cells. The anti-JL1 immunonanoplexes were able to deliver siRNA specifically to leukemic cells (CEM and Jurkat), but not to control cancer cells (H9). According to FACS and confocal microscopic analysis, siRNAs delivered by immunonanoplex particles were rapidly taken up by the JL1-positive cancer cells in 2 h. Furthermore, we showed that the anti-JL1 immunonanoplexes were effectively targeted to JL1-positive cells (CEM) inoculated in the mouse bone marrow. These results suggest that the anti-JL1 immunonanoplex is a powerful siRNA delivery system for human leukemia therapies.ko_KR
dc.language.isoenko_KR
dc.publisherKOREAN SOC MOLECULAR & CELLULAR BIOLOGYko_KR
dc.subject9-arginine peptideko_KR
dc.subjectsiRNAko_KR
dc.subjectleukemia therapyko_KR
dc.subjectimmunonanoplexko_KR
dc.subjectanti-JL1 minibodyko_KR
dc.titleLeukemia-specific siRNA delivery by immunonanoplexes consisting of anti-JL1 minibody conjugated to oligo-9 Arg-peptidesko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이연경-
dc.contributor.AlternativeAuthor김근식-
dc.contributor.AlternativeAuthor김정석-
dc.contributor.AlternativeAuthor백진이-
dc.contributor.AlternativeAuthor박상일-
dc.contributor.AlternativeAuthor정화연-
dc.contributor.AlternativeAuthor윤상순-
dc.contributor.AlternativeAuthor정경천-
dc.contributor.AlternativeAuthor송형근-
dc.contributor.AlternativeAuthor박용석-
dc.identifier.doi10.1007/s10059-010-0056-5-
dc.citation.journaltitleMOLECULES AND CELLS-
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dc.description.tc2-
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