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Immunohistochemical and Molecular Characteristics of Follicular Patterned Thyroid Nodules with Incomplete Nuclear Features of Papillary Thyroid Carcinoma
DC Field | Value | Language |
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dc.contributor.author | Min, Hye Sook | - |
dc.contributor.author | Choe, Gheeyoung | - |
dc.contributor.author | Cho, Nam-Yun | - |
dc.contributor.author | Kang, Gyeong Hoon | - |
dc.contributor.author | Park, So Yeon | - |
dc.contributor.author | Park, Seong Hoe | - |
dc.date.accessioned | 2012-06-04T00:49:00Z | - |
dc.date.available | 2012-06-04T00:49:00Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | KOREAN JOURNAL OF PATHOLOGY; Vol.43 6; 495-502 | ko_KR |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76741 | - |
dc.description.abstract | Background : Follicular patterned thyroid nodules with incomplete nuclear features of papillary thyroid carcinoma (FTN-INPTCs) are difficult to diagnose, and their biological behavior and association with follicular variants of PTC (FVPTCs) have not yet been established. The aim of this study is to determine immunohistochemical and molecular characteristics of FTN-INPTCs. Methods : We investigated immunohistochemical features (galectin-3, HBME-1, CK19, fibronectin-1, CITED1), BRAF V600E mutation and RASSF1A promoter methylation status in 30 FTN-INPTC cases, along with 26 FVPTCs, 21 follicular adenomas (FAs) and 14 nodular hyperplasias (NHs). Results : Expression of galectin-3, HBME-1, CK19 and CITED1 was significantly higher in FTN-INPTCs than in FAs or NHs, but expression of galectin-3, CK19 and fibronectin-1 was lower in FTN-INPTCs than in FVPTCs. The BRAF V600E mutation was not detected in the benign nodules or FTN-INPTCs, whereas 57% of FVPTCs had the mutation. RASSF1A promoter methylation was higher in FTN-INPTCs than in benign nodules but there was no difference between FTN-INPTCs and FVPTCs. Conclusions : Our results represent the borderline immunohistochemical and molecular characteristics of FTN-INPTC. We conclude that FTN-INPTC is an intermediate lesion between a benign nodule and a FVPTC, and that it is pathogenetically related to FVPTC. | ko_KR |
dc.description.sponsorship | This work was supported by the Korea Research
Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2006- 331-E00050). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN SOCIETY PATHOLOGISTS | ko_KR |
dc.subject | Thyroid gland | ko_KR |
dc.subject | Thyroid neoplasms | ko_KR |
dc.subject | Carcinoma | ko_KR |
dc.subject | Papillary | ko_KR |
dc.title | Immunohistochemical and Molecular Characteristics of Follicular Patterned Thyroid Nodules with Incomplete Nuclear Features of Papillary Thyroid Carcinoma | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 민혜숙 | - |
dc.contributor.AlternativeAuthor | 최기영 | - |
dc.contributor.AlternativeAuthor | 조남윤 | - |
dc.contributor.AlternativeAuthor | 강경훈 | - |
dc.contributor.AlternativeAuthor | 박성회 | - |
dc.contributor.AlternativeAuthor | 박소연 | - |
dc.identifier.doi | 10.4132/KoreanJPathol.2009.43.6.495 | - |
dc.citation.journaltitle | KOREAN JOURNAL OF PATHOLOGY | - |
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dc.description.tc | 1 | - |
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