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Expression of vascular endothelial growth factor-A and its receptor-1 in a luteal endometrium in patients with repeated in vitro fertilization failure
DC Field | Value | Language |
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dc.contributor.author | Jee, Byung Chul | - |
dc.contributor.author | Suh, Chang Suk | - |
dc.contributor.author | Kim, Ki Chul | - |
dc.contributor.author | Lee, Won Don | - |
dc.contributor.author | Kim, Seok Hyun | - |
dc.contributor.author | Kim, Haeryoung | - |
dc.date.accessioned | 2012-06-04T04:50:05Z | - |
dc.date.available | 2012-06-04T04:50:05Z | - |
dc.date.issued | 2009-02 | - |
dc.identifier.citation | FERTILITY AND STERILITY; Vol.91 2; 528-534 | ko_KR |
dc.identifier.issn | 0015-0282 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76773 | - |
dc.description.abstract | Objective: To investigate temporal and spatial relationships of vascular endothelial growth factor (VEGF)-A and its receptor (VEGFR-1) expression in a luteal endometrium obtained from patients with repeated IVF failure. Design: Immunohistochemical study. Setting: University hospital. Patient(S): Thirty-three regular-cycling infertile women (mean age, 34.4 years) who experienced three or more failed IVF cycles (range, 3-14 cycles). Intervention(s): Endometrial samplings by silastic suction curette in the luteal phase of a spontaneous unmedicated cycle. Main Outcome Measure(s): Immunohistochemical intensity scoring after staining by monoclonal anti-VEGF-A and polyclonal anti-VEGFR-1. Microvascular density determined after staining by monoclonal anti-CD31 antibody. The data were compared in three phases; early (cycle day [CD]16-19) (n = 12), mid- (CD20-24) (n = 13), and late luteal phase (CD25-27) (n = 8). Result(S): Expression of VEGF-A tended to be lower in midluteal endometrium at epithelial, stromal, and endothelial cells. Expression of VEGFR-1 at epithelial cells was highest in midluteal endometrium, but VEGFR-1 at stroma and endothelium and microvascular density continuously decreased throughout luteal-phase endometrium. Conclusion(s): In contrast to previous reports, VEGF-A expression was not highest in the midluteal phase in repeated IVF failure patients who had no apparent endometrial patholog. Further research is needed to determine whether different VEGF-A expression patterns in the luteal phase contribute to repeated IVF failure. (Fertil Steril(R) 2009;91:528-34. (C)2009 by American Society for Reproductive Medicine.) | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE INC | ko_KR |
dc.subject | vascular endothelial growth factor | ko_KR |
dc.subject | human endometrium | ko_KR |
dc.subject | repeated implantation failure | ko_KR |
dc.subject | IVF | ko_KR |
dc.title | Expression of vascular endothelial growth factor-A and its receptor-1 in a luteal endometrium in patients with repeated in vitro fertilization failure | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 조병철 | - |
dc.contributor.AlternativeAuthor | 서창석 | - |
dc.contributor.AlternativeAuthor | 김기철 | - |
dc.contributor.AlternativeAuthor | 이원돈 | - |
dc.contributor.AlternativeAuthor | 김혜령 | - |
dc.contributor.AlternativeAuthor | 김석현 | - |
dc.identifier.doi | 10.1016/j.fertnstert.2007.11.081 | - |
dc.citation.journaltitle | FERTILITY AND STERILITY | - |
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dc.description.tc | 2 | - |
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