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Effect of sphingosine-1-phosphate supplementation on follicular integrity of vitrified-warmed mouse ovarian grafts
DC Field | Value | Language |
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dc.contributor.author | Jee, Byung Chul | - |
dc.contributor.author | Lee, Jung Ryeol | - |
dc.contributor.author | Youm, Hyewon | - |
dc.contributor.author | Suh, Chang Suk | - |
dc.contributor.author | Moon, Shin Yong | - |
dc.contributor.author | Kim, Seok Hyun | - |
dc.date.accessioned | 2012-06-04T05:24:34Z | - |
dc.date.available | 2012-06-04T05:24:34Z | - |
dc.date.issued | 2010-10 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY; Vol.152 2; 176-180 | ko_KR |
dc.identifier.issn | 0301-2115 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76780 | - |
dc.description.abstract | Objective: To investigates the effect of sphingosine-1-phosphate (SIP) supplementation on follicular integrity and apoptosis in vitrified-warmed mouse ovarian grafts. Study design: Ovaries from 4-week-aged ICR mice were vitrified using a vitrification solution with or without 2 mu M S1P. After warming, follicular normality was assessed by histological analysis and TUNEL assay. A part of ovaries vitrified with or without 21 mu M S1P was transplanted, and 2 weeks later, gross and microscopic follicular morphology was assessed. Results: During vitrification and warming, inclusion of 2 mu M S1P into the vitrification solution significantly raised the rate of morphologically intact follicles compared to controls (36.6% vs. 30.8%, p = 0.047). This protective effect was profound especially in primordial follicles (45.5% vs. 34.6%, p = 0.034). After transplantation of vitrified-warmed ovaries, the morphological integrity of primordial follicles was superior in the S1P-treated group (55.0% vs. 39.4%, p = 0.035). The rates of non-apoptotic follicles (TUNEL-negative) were similar in the two groups in either non-transplanted or transplanted ovaries. Conclusion: Inclusion of SIP in the vitrification solution during transplantation of vitrified-warmed ovary had a beneficial effect on preservation of the primordial follicular pool. (C) 2010 Elsevier Ireland Ltd. All rights reserved. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE BV | ko_KR |
dc.subject | Vitrification | ko_KR |
dc.subject | Sphingosine-1-phosphate | ko_KR |
dc.subject | Transplantation | ko_KR |
dc.subject | Ovary | ko_KR |
dc.title | Effect of sphingosine-1-phosphate supplementation on follicular integrity of vitrified-warmed mouse ovarian grafts | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 지병철 | - |
dc.contributor.AlternativeAuthor | 이정렬 | - |
dc.contributor.AlternativeAuthor | 서창석 | - |
dc.contributor.AlternativeAuthor | 김석현 | - |
dc.contributor.AlternativeAuthor | 문신용 | - |
dc.identifier.doi | 10.1016/j.ejogrb.2010.06.019 | - |
dc.citation.journaltitle | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | - |
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dc.description.tc | 0 | - |
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