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Effects of adding luteinizing hormone activity to gonadotropin releasing hormone antagonist protocols may differ according to age

Cited 6 time in Web of Science Cited 7 time in Scopus
Authors
Kim, Yong Jin; Ku, Seung-Yup; Jee, Byung Chul; Suh, Chang Suk; Choi, Young Min; Moon, Shin Yong; Kim, Jung Gu; Kim, Seok Hyun
Issue Date
2010-04
Publisher
INFORMA HEALTHCARE
Citation
GYNECOLOGICAL ENDOCRINOLOGY; Vol.26 4; 256-260
Keywords
LHGnRH antagonistIVFICSI
Abstract
Objective. In spite of previous reports on the beneficial effects of adding exogenous luteinizing hormone (LH) activity
to gonadotropin releasing hormone (GnRH) antagonist protocols for conventional in vitro fertilization (IVF) or
intracytoplasmic sperm injection (ICSI), these effects in various age groups are still controversial. This study was performed
to evaluate the clinical efficacy of adding LH activity to GnRH antagonist protocols according to patient’s age. Methods. In this medical record review, responses to controlled ovarian hyperstimulation (COH) and IVF/ICSI outcomes were compared between follicle stimulating hormone (FSH) alone and FSH supplemented with LH activity groups in women < 35 years (n = 135) and those > 35 years (n = 97), respectively. Results. Estradiol level on hCG day in LH-added group was higher (2.150.6 +/- 1.345.1 pg/ml vs. 1.606.2 +/- 994.6 pg/ml, P = 0.011) in women < 35 years, while it did not differ in those > 35 years. Less oocytes were retrieved in LH-added group of women > 35 years (8.1 +/- 6.5 vs. 5.7 +/- 3.0, P = 0.013), however, this figure did not differ in those < 35 years. Regardless of age, the clinical pregnancy rates were not different between the two groups. Conclusions. Supplementation of exogenous LH activity to GnRH antagonist protocols affects the COH outcomes. These LH-adding effects may vary according to patient`s age.
ISSN
0951-3590
Language
English
URI
http://hdl.handle.net/10371/76822
DOI
https://doi.org/10.3109/09513590903247865
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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