Browse

Intercellular Adhesion Molecule-1 and Interleukin-6 Gene Polymorphisms in Patients with Advanced-Stage Endometriosis

Cited 10 time in Web of Science Cited 11 time in Scopus
Authors
Chae, Soo Jin; Lee, Gyoung Hoon; Choi, Young Min; Hong, Min A; Lee, Kyu Sup; Moon, Shin Yong; Ku, Seung Yup; Kim, Jong Mee
Issue Date
2010
Publisher
KARGER
Citation
GYNECOLOGIC AND OBSTETRIC INVESTIGATION; Vol.70 1; 34-39
Keywords
EndometriosisIntercellular adhesion molecule-1Interleukin-6Polymorphism
Abstract
Background/Aims: The aim of this study was to investigate the possibility that the K469E and G241R polymorphisms in the intercellular adhesion molecule-1 (ICAM-1) gene and the C-634G polymorphism in the interleukin (IL)-6 gene are associated with endometriosis in the Korean population. Methods: The ICAM-1 gene K469E and G241R polymorphisms and the IL-6 gene C-634G polymorphism were evaluated in 390 patients with endometriosis and 351 controls by polymerase chain reaction-restriction fragment length polymorphism analysis. Results: The ICAM-1 gene G241R polymorphism was not observed in all subjects. No differences were observed in the ICAM-1 K469E and IL-6 C-634G genotype distributions and allele frequencies between patients with endometriosis and controls. In subgroup analyses according to the stage of endometriosis or bilaterality of ovarian endometriomas, no significant differences were observed in the ICAM-1 gene K469E or the IL-6 gene C-634G polymorphism frequencies between the subgroups and the controls. The combined analysis of the ICAM-1 gene K469E polymorphism and the IL-6 gene C-634G polymorphism did not show any additional significant findings. Conclusions: The K469E and G241R polymorphisms in the ICAM-1 gene and the C-634G polymorphism in the IL-6 gene may not be genetic factors related to susceptibility to advanced-stage endometriosis in the Korean population. Copyright (C) 2010 S. Karger AG, Basel
ISSN
0378-7346
Language
English
URI
http://hdl.handle.net/10371/76831
DOI
https://doi.org/10.1159/000284398
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse