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Comprehensive analysis of microRNA-mRNA co-expression in circadian rhythm
DC Field | Value | Language |
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dc.contributor.author | Na, Young-Ji | - |
dc.contributor.author | Sung, Jung Hwan | - |
dc.contributor.author | Lee, Suk Chan | - |
dc.contributor.author | Lee, Young-Ju | - |
dc.contributor.author | Park, Woong-Yang | - |
dc.contributor.author | Kim, Ju Han | - |
dc.contributor.author | Shin, Hee Sup | - |
dc.contributor.author | Choi, Yeun Joo | - |
dc.date.accessioned | 2012-06-05T06:18:18Z | - |
dc.date.available | 2012-06-05T06:18:18Z | - |
dc.date.issued | 2009-09-30 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE; Vol.41 9; 638-647 | ko_KR |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76858 | - |
dc.description.abstract | To investigate the potential role of microRNA (miRNA) in the regulation of circadian rhythm, we performed microarray-based expression profiling study of both miRNA and mRNA in mouse liver for 48 h at 4-hour intervals. Circadian miRNA-mRNA target pair is defined as the pair both elements of which show circadian expression patterns and the sequence-based target relationship of which can be predicted. Circadian initiators, Clock and Bmal1, showed inversely correlated circadian expression patterns against their corresponding miRNAs, miR-181d and miR-191, targeting them. In contrast, circadian suppressors, Per, Cry, Me and Rev-erba, exhibited positively correlated circadian expression patterns to their corresponding miRNAs. Genomic location analysis revealed that intronic region showed higher abundance of cyclic than non-cyclic miRNAs targeting circadian genes while other (i.e., 3`-UTR, exon and intergenic) regions showed no difference. It is suggested that miRNAs are involved in the regulation of peripheral circadian rhythm in mouse liver by modulating Clock:Bmal1 complex. Identifying specific miRNAs and their targets that are critically involved in circadian rhythm will provide a better understanding of the regulation of circadian-clock system. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | ko_KR |
dc.subject | circadian rhythm | ko_KR |
dc.subject | gene expression profiling | ko_KR |
dc.subject | gene expression regulation | ko_KR |
dc.subject | microRNA | ko_KR |
dc.subject | mice | ko_KR |
dc.subject | liver | ko_KR |
dc.title | Comprehensive analysis of microRNA-mRNA co-expression in circadian rhythm | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 나영지 | - |
dc.contributor.AlternativeAuthor | 성정환 | - |
dc.contributor.AlternativeAuthor | 이석찬 | - |
dc.contributor.AlternativeAuthor | 이영주 | - |
dc.contributor.AlternativeAuthor | 최연주 | - |
dc.contributor.AlternativeAuthor | 박웅양 | - |
dc.contributor.AlternativeAuthor | 신희섭 | - |
dc.contributor.AlternativeAuthor | 김주한 | - |
dc.identifier.doi | 10.3858/emm.2009.41.9.070 | - |
dc.citation.journaltitle | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
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