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`Real World` Comparison of Drug-Eluting Stents vs Bare Metal Stents in the Treatment of Unselected Patients With Acute ST-Segment Elevation Myocardial Infarction

Cited 13 time in Web of Science Cited 17 time in Scopus
Authors
Park, Kyung Woo; Kang, Si-Hyuck; Chung, Woo-Young; Lee, Hae-Young; Kang, Hyun-Jae; Youn, Tae-Jin; Chae, In-Ho; Hahn, Seokyung; Kim, Hyo-Soo; Park, Byung-Joo; Choi, Dong-Ju; Koo, Bon-Kwon; Cho, Young-Seok; Park, Jin-Shik
Issue Date
2010-06
Publisher
JAPANESE CIRCULATION SOC
Citation
CIRCULATION JOURNAL; Vol.74 6; 1111-1120
Keywords
Drug-eluting stentsPercutaneous coronary intervention (PCI)Myocardial infarction
Abstract
Background: Concerns exist regarding the long-term efficacy and safety of drug-eluting stents (DES) in patients with ST-segment elevation myocardial infarction (STEMI). The study aimed to compare the mid- to long-term outcomes of DES vs bare metal stents (BMS) in patients with STEMI in a real-world setting. Methods and Results: Six hundred and eighty four consecutive patients with STEMI who underwent percutaneous coronary intervention from January 2003 to December 2006 were analyzed; 539 patients (78.8%) with DES and 145 (21.2%) with BMS. Patients were followed for the occurrence of target vessel failure (TVF); a composite of cardiac death, non-fatal myocardial infarction, or target vessel revascularization (TVR). After a follow-up duration of 36 months, the TVF rate was significant lower in the DES group compared with the BMS group (17.8% vs 34.5%, P<0.01), which was mainly driven by a decrease in TVR (9.1% vs 22.8%, P<0.01). Diabetic patients, those with multivessel disease and those treated with smaller or longer stents benefited more from DES implantation. Propensity score matching concordantly indicated a benefit of DES with regard to TVF (13.5% vs 34.2%; P<0.01). The overall incidence of stent thrombosis (ST) in each group was comparable (3.9% vs 4.1%, P=0.47). Conclusions: Compared to BMS, the mid- to long-term outcome was better in patients receiving DES for acute STEMI. This was driven mainly by a reduction in repeat revascularization. (Circ J 2010; 74: 1111-1120)
ISSN
1346-9843
Language
English
URI
http://hdl.handle.net/10371/76905
DOI
https://doi.org/10.1253/circj.CJ-09-0936
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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