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Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women

Cited 126 time in Web of Science Cited 134 time in Scopus
Authors
Yang, Yoon Jung; Hong, Yun-Chul; Oh, Se-Young; Park, Min-Seon; Leem, Jong-Han; Ha, Eun-Hee; Kim, Ho
Issue Date
2009-08
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
ENVIRONMENTAL RESEARCH; Vol.109 6; 797-801
Keywords
Bisphenol ACross-sectional studiesOxidative stressInflammationPostmenopausal woman
Abstract
Bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. There is increasing health concerns regarding low-level exposure to BPA among the general population. The aim of this study was to determine the association between BPA exposure with oxidative stress and inflammation in adult populations. A cross-sectional study was conducted. This study included 485 adults (259 men, 92 premenopausal women, and 134 postmenopausal women) living in general communities within large cities. Urinary concentrations of BPA, malondialdehyde (MIDA), and 8-hydroxydeoxyguanosine (8-OHdG), white blood cell (WBC) count, and C-reactive protein (CRP) were measured. Multivariate analyses were applied to determine the associations of BPA exposure with oxidative stress and inflammation. The geometric means of urinary BPA for men, premenopausal women, and postmenopausal women were 0.53, 0.61, and 0.58 mu g/g cr, respectively. The urinary BPA concentrations were positively associated with MDA, 8-OHdG, and CRP levels in the postmenopausal women; however, such associations did not exist in men and premenopausal women. The findings of this study suggest that BPA exposure would promote oxidative stress and inflammation, in which postmenopausal women are likely to be more susceptible to BPA-induced health effects. (C) 2009 Elsevier Inc. All rights reserved.
ISSN
0013-9351
Language
English
URI
http://hdl.handle.net/10371/76919
DOI
https://doi.org/10.1016/j.envres.2009.04.014
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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