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Clinical Application of Liver MR Imaging in Wilson`s Disease
DC Field | Value | Language |
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dc.contributor.author | Cheon, Jung-Eun | - |
dc.contributor.author | Kim, In-One | - |
dc.contributor.author | Seo, Jeong Kee | - |
dc.contributor.author | Ko, Jae Sung | - |
dc.contributor.author | Shin, Cheong-Il | - |
dc.contributor.author | Yeon, Kyung Mo | - |
dc.contributor.author | Kim, Woo Sun | - |
dc.contributor.author | Lee, Jeong Min | - |
dc.date.accessioned | 2012-06-12T04:38:24Z | - |
dc.date.available | 2012-06-12T04:38:24Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | KOREAN JOURNAL OF RADIOLOGY; Vol.11 6; 665-672 | ko_KR |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76996 | - |
dc.description.abstract | Objective: To determine whether there is a correlation between liver MR findings and the clinical manifestations and severity of liver dysfunction in patients with Wilson`s disease. Materials and Methods: Two radiologists retrospectively evaluated MR images of the liver in 50 patients with Wilson`s disease. The Institutional Review Board approved this retrospective study and informed consent was waived. MR images were evaluated with a focus on hepatic contour abnormalities and the presence of intrahepatic nodules. By using Fisher`s exact test, MR findings were compared with clinical presentations (neurological and non-neurological) and hepatic dysfunction, which was categorized by the Child-Pugh classification system (A, B and C). Follow-up MR images were available for 17 patients. Results: Contour abnormalities of the liver and intrahepatic nodules were observed in 31 patients (62%) and 25 patients (50%), respectively. Each MR finding showed a statistically significant difference (p < 0.05) among the three groups of Child-Pugh classifications (A, n = 36; B, n = 5; C, n = 9), except for splenomegaly (p = 0.243). The mean age of the patients with positive MR findings was higher than that of patients with negative MR findings. For patients with Child-Pugh class A (n = 36) with neurological presentation, intrahepatic nodules, surface nodularity, and gallbladder fossa widening were more common. Intrahepatic nodules were improved (n = 8, 47%), stationary (n = 5, 29%), or aggravated (n = 4, 24%) on follow-up MR images. Conclusion: MR imaging demonstrates the contour abnormalities and parenchymal nodules of the liver in more than half of the patients with Wilson`s disease, which correlates with the severity of hepatic dysfunction and clinical manifestations. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN RADIOLOGICAL SOC | ko_KR |
dc.subject | Hepatolenticular degeneration | ko_KR |
dc.subject | Liver | ko_KR |
dc.subject | Magnetic resonance (MR) | ko_KR |
dc.title | Clinical Application of Liver MR Imaging in Wilson`s Disease | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 전정은 | - |
dc.contributor.AlternativeAuthor | 김인원 | - |
dc.contributor.AlternativeAuthor | 서정기 | - |
dc.contributor.AlternativeAuthor | 고재성 | - |
dc.contributor.AlternativeAuthor | 이정민 | - |
dc.contributor.AlternativeAuthor | 신청일 | - |
dc.contributor.AlternativeAuthor | 김우선 | - |
dc.contributor.AlternativeAuthor | 연경모 | - |
dc.identifier.doi | 10.3348/kjr.2010.11.6.665 | - |
dc.citation.journaltitle | KOREAN JOURNAL OF RADIOLOGY | - |
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dc.description.tc | 1 | - |
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