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Seroprevalence rate after one dose of varicella vaccine in infants
DC Field | Value | Language |
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dc.contributor.author | Kim, So Hee | - |
dc.contributor.author | Lee, Hoan Jong | - |
dc.contributor.author | Park, Su Eun | - |
dc.contributor.author | Oh, Sung Hee | - |
dc.contributor.author | Choi, Eun Hwa | - |
dc.contributor.author | Lee, Seong Yeon | - |
dc.date.accessioned | 2012-06-12T04:52:56Z | - |
dc.date.available | 2012-06-12T04:52:56Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.citation | JOURNAL OF INFECTION; Vol.61 1; 66-72 | ko_KR |
dc.identifier.issn | 0163-4453 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77000 | - |
dc.description.abstract | Background: Live, attenuated varicella vaccine has been used since 1988 in Korea. However, varicella is still prevalent among both vaccinated and unvaccinated individuals, despite a relatively high level of immunization rate up to 80%. A recent report has demonstrated similar to 20% of primary vaccine failure rate after one dose of varicella vaccine using the fluorescent antibody to membrane antigen (FAMA) assay. Methods: The seroprevalence rate was determined using the FAMA and ELISA assays in 67 Korean infants following one dose of varicella vaccine. Positive fluorescence at a serum dilution of 1: 4 or greater was considered as seropositive. Results: The median age at vaccination was 12 months and the post-immunization sera were obtained on average 6.3 months (range 6 weeks-12 months) after vaccination. Among the 67 vaccinated infants, 56 (83.6%) were seropositive by FAMA assay while 30 (44.8%) were seropositive by ELISA. The geometric mean titers (GMTs) of the seropositive vaccinated infants (n = 56) were significantly lower than the GMTs of 9 individuals with a history of varicella (1:17.0 vs. 1:74.7, P = 0.001). Although there were no significant differences in seropositive rates according to intervals, there was a decreasing trend in the GMTs over time among the 56 seropositive recipients (r(2) = 0.154, P < 0.001). Conclusions: These data can be useful for optimizing the immunization strategy against varicella and should be confirmed by a prospective study including a large number of immunized infants. (c) 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | W B SAUNDERS CO LTD | ko_KR |
dc.subject | Varicella vaccine | ko_KR |
dc.subject | Fluorescent antibody to membrane antigen | ko_KR |
dc.subject | Seroprevalence | ko_KR |
dc.title | Seroprevalence rate after one dose of varicella vaccine in infants | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김소희 | - |
dc.contributor.AlternativeAuthor | 이환종 | - |
dc.contributor.AlternativeAuthor | 박수은 | - |
dc.contributor.AlternativeAuthor | 오성희 | - |
dc.contributor.AlternativeAuthor | 이성연 | - |
dc.contributor.AlternativeAuthor | 최은화 | - |
dc.identifier.doi | 10.1016/j.jinf.2010.04.001 | - |
dc.citation.journaltitle | JOURNAL OF INFECTION | - |
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dc.description.tc | 1 | - |
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