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A Role of Canonical Transient Receptor Potential 5 Channel in Neuronal Differentiation from A2B5 Neural Progenitor Cells
DC Field | Value | Language |
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dc.contributor.author | Shin, Hye Young | - |
dc.contributor.author | Hong, Yun Hwa | - |
dc.contributor.author | Jang, Sung Soo | - |
dc.contributor.author | Chae, Hong Gu | - |
dc.contributor.author | Moon, Hyo Eun | - |
dc.contributor.author | Kim, Jun | - |
dc.contributor.author | Kim, Sang Jeong | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.contributor.author | Paek, Seung Leal | - |
dc.date.accessioned | 2012-06-13T07:31:47Z | - |
dc.date.available | 2012-06-13T07:31:47Z | - |
dc.date.issued | 2010-05-07 | - |
dc.identifier.citation | PLOS ONE; Vol.5 5; e10359 | ko_KR |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77039 | - |
dc.description.abstract | Store-operated Ca(2+) entry (SOCE) channels are the main pathway of Ca(2+) entry in non-excitable cells such as neural progenitor cells (NPCs). However, the role of SOCE channels has not been defined in the neuronal differentiation from NPCs. Here, we show that canonical transient receptor potential channel (TRPC) as SOCE channel influences the induction of the neuronal differentiation of A2B5(+) NPCs isolated from postnatal-12-day rat cerebrums. The amplitudes of SOCE were significantly higher in neural cells differentiated from proliferating A2B5+ NPCs and applications of SOCE blockers, 2-aminoethoxy-diphenylborane (2-APB), and ruthenium red (RR), inhibited their rise of SOCE. Among TRPC subtypes (TRPC1-7), marked expression of TRPC5 and TRPC6 with turned-off TRPC1 expression was observed in neuronal cells differentiated from proliferating A2B5(+) NPCs. TRPC5 small interfering RNA (siRNA) blocked the neuronal differentiation from A2B5(+) NPCs and reduced the rise of SOCE. In contrast, TRPC6 siRNA had no significant effect on the neuronal differentiation from A2B5(+) NPCs. These results indicate that calcium regulation by TRPC5 would play a key role as a switch between proliferation and neuronal differentiation from NPCs. | ko_KR |
dc.description.sponsorship | This study was supported in part by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of
Korea (A04-0018-AY1204-08A5-00050B), a grant of Seoul National University Hospital, and grants of Korea Research Foundation funded by the ministry of Education, Science and Technology (No. 2009-0080939 and WCU program R32-10142). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | PUBLIC LIBRARY SCIENCE | ko_KR |
dc.title | A Role of Canonical Transient Receptor Potential 5 Channel in Neuronal Differentiation from A2B5 Neural Progenitor Cells | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 신혜영 | - |
dc.contributor.AlternativeAuthor | 홍윤화 | - |
dc.contributor.AlternativeAuthor | 장성수 | - |
dc.contributor.AlternativeAuthor | 채홍구 | - |
dc.contributor.AlternativeAuthor | 백승렬 | - |
dc.contributor.AlternativeAuthor | 문효은 | - |
dc.contributor.AlternativeAuthor | 김동규 | - |
dc.contributor.AlternativeAuthor | 김준 | - |
dc.contributor.AlternativeAuthor | 백선하 | - |
dc.contributor.AlternativeAuthor | 김상정 | - |
dc.identifier.doi | 10.1371/journal.pone.0010359 | - |
dc.citation.journaltitle | PLOS ONE | - |
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