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Plasma matrix metalloproteinases, cytokines and angiogenic factors in moyamoya disease

Cited 78 time in Web of Science Cited 80 time in Scopus
Authors
Kang, Hyun-Seung; Kim, Jin Hyun; Phi, Ji Hoon; Kim, Young-Yim; Wang, Kyu-Chang; Kim, Seung-Ki; Cho, Byung-Kyu; Kim, Jeong Eun
Issue Date
2010-06
Publisher
B M J PUBLISHING GROUP
Citation
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY; Vol.81 6; 673-678
Abstract
Objective To document the expression patterns of various matrixins, cytokines and angiogenic factors in plasma to assess their involvement in the pathogenesis of moyamoya disease (MMD). Methods This study included plasma samples from 20 MMD patients and nine healthy individuals. The plasma concentration of five matrix metalloproteinases (MMP-1, MMP-2, MMP-3, MMP-9, MMP-12), monocyte chemoattractant protein-1 (MCP-1), resistin, three interleukins (IL-1 beta, IL-6, IL-8), tumour necrosis factor-alpha, vascular endothelial growth factor (VEGF), platelet-derived growth factor BB (PDGF-BB) and basic fibroblast growth factor was determined using multianalyte profiling systems. The concentration of the tissue inhibitors of metalloproteinase (TIMP-1 and TIMP-2) was measured using ELISA. Gelatin zymography for MMP-2 and MMP-9 was also performed. Results MMD patients exhibited significantly higher plasma concentrations of MMP-9, MCP-1, IL-1 beta, VEGF and PDGF-BB, and lower plasma concentrations of MMP-3, TIMP-1 and TIMP-2 compared with healthy controls. Significant correlations were found among MMP-9, MCP-1, VEGF, PDGF-BB and TIMP-2 in MMD patients. Conclusion There were distinctive expression patterns of matrixins, cytokines and angiogenic factors in MMD patients, which seemed to correlate with disease pathogenesis. The balance between MMPs and TIMPs was disrupted in MMD and correlated with disease pathogenesis. Increased plasma levels of MCP-1 and VEGF in MMD patients may play a role in the recruitment of vascular progenitor cells and in the formation of collateral vessels.
ISSN
0022-3050
Language
English
URI
http://hdl.handle.net/10371/77042
DOI
https://doi.org/10.1136/jnnp.2009.191817
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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