Publications
Detailed Information
Evidence for the Existence of Secretory Granule (Dense-Core Vesicle)-Based Inositol 1,4,5-Trisphosphate-Dependent Ca(2+) Signaling System in Astrocytes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hur, Yong Suk | - |
dc.contributor.author | Kim, Ki Deok | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.contributor.author | Yoo, Seung Hyun | - |
dc.date.accessioned | 2012-06-13T08:50:24Z | - |
dc.date.available | 2012-06-13T08:50:24Z | - |
dc.date.issued | 2010-08-05 | - |
dc.identifier.citation | PLOS ONE; Vol.5 8; e11973 | ko_KR |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77046 | - |
dc.description.abstract | Background: The gliotransmitters released from astrocytes are deemed to play key roles in the glial cell-neuron communication for normal function of the brain. The gliotransmitters, such as glutamate, ATP, D-serine, neuropeptide Y, are stored in vesicles of astrocytes and secreted following the inositol 1,4,5-trisphosphate (IP(3))-induced intracellular Ca(2+) releases. Yet studies on the identity of the IP(3)-dependent intracellular Ca(2+) stores remain virtually unexplored. Principal Findings: We have therefore studied the potential existence of the IP(3)-sensitive intracellular Ca(2+) stores in the cytoplasm of astrocytes using human brain tissue samples in contrast to cultured astrocytes that had primarily been used in the past. It was thus found that secretory granule marker proteins chromogranins and secretogranin II localize in the large dense core vesicles of astrocytes, thereby confirming the large dense core vesicles as bona fide secretory granules. Moreover, consistent with the major IP(3)-dependent intracellular Ca(2+) store role of secretory granules in secretory cells, secretory granules of astrocytes also contained all three (types 1, 2, and 3) IP(3)R isoforms. Significance: Given that the secretory granule marker proteins chromogranins and secretogranin II are high-capacity, low-affinity Ca(2+) storage proteins and chromogranins interact with the IP(3)Rs to activate the IP(3)R/Ca(2+) channels, i.e., increase both the mean open time and the open probability of the channels, these results imply that secretory granules of astrocytes function as the IP(3)-sensitive intracellular Ca(2+) store. | ko_KR |
dc.description.sponsorship | The present work was funded in part by the Brain Korea 21 Program of the Republic of Korea. The funder had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | PUBLIC LIBRARY SCIENCE | ko_KR |
dc.title | Evidence for the Existence of Secretory Granule (Dense-Core Vesicle)-Based Inositol 1,4,5-Trisphosphate-Dependent Ca(2+) Signaling System in Astrocytes | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 허용석 | - |
dc.contributor.AlternativeAuthor | 김기덕 | - |
dc.contributor.AlternativeAuthor | 백선하 | - |
dc.contributor.AlternativeAuthor | 유승현 | - |
dc.identifier.doi | 10.1371/journal.pone.0011973 | - |
dc.citation.journaltitle | PLOS ONE | - |
dc.description.citedreference | Yoo SH, 2010, FASEB J, V24, P653, DOI 10.1096/fj.09-132456 | - |
dc.description.citedreference | Kang SS, 2010, CANCER RES, V70, P1173, DOI 10.1158/0008-5472.CAN-09-2886 | - |
dc.description.citedreference | Paco S, 2009, J NEUROCHEM, V110, P143, DOI 10.1111/j.1471-4159.2009.06116.x | - |
dc.description.citedreference | Gerasimenko JV, 2009, P NATL ACAD SCI USA, V106, P10758, DOI 10.1073/pnas.0904818106 | - |
dc.description.citedreference | Zhang XH, 2009, J NEUROSCI, V29, P7766, DOI 10.1523/JNEUROSCI.0389-09.2009 | - |
dc.description.citedreference | Santello M, 2009, NEUROSCIENCE, V158, P253, DOI 10.1016/j.neuroscience.2008.03.039 | - |
dc.description.citedreference | Ramamoorthy P, 2008, J NEUROSCI, V28, P13815, DOI 10.1523/JNEUROSCI.5361-07.2008 | - |
dc.description.citedreference | SantoDomingo J, 2008, EUR J NEUROSCI, V28, P1265, DOI 10.1111/j.1460-9568.2008.06440.x | - |
dc.description.citedreference | Martineau M, 2008, GLIA, V56, P1271, DOI 10.1002/glia.20696 | - |
dc.description.citedreference | Montero-Hadjadje M, 2008, ACTA PHYSIOL, V192, P309, DOI 10.1111/j.1748-1716.2007.01806.x | - |
dc.description.citedreference | Potokar M, 2008, GLIA, V56, P135, DOI 10.1002/glia.20597 | - |
dc.description.citedreference | Petersen OH, 2008, ANNU REV PHYSIOL, V70, P273, DOI 10.1146/annurev.physiol.70.113006.100618 | - |
dc.description.citedreference | Yoo SH, 2007, BIOCHEMISTRY-US, V46, P14663, DOI 10.1021/bi701339m | - |
dc.description.citedreference | Huh YH, 2007, BIOCHEMISTRY-US, V46, P14032, DOI 10.1021/bi701364p | - |
dc.description.citedreference | Pangrsic T, 2007, J BIOL CHEM, V282, P28749, DOI 10.1074/jbc.M700290200 | - |
dc.description.citedreference | Striedinger K, 2007, GLIA, V55, P652, DOI 10.1002/glia.20494 | - |
dc.description.citedreference | Foskett JK, 2007, PHYSIOL REV, V87, P593, DOI 10.1152/physrev.00035.2006 | - |
dc.description.citedreference | Montana V, 2006, GLIA, V54, P700, DOI 10.1002/glia.20367 | - |
dc.description.citedreference | Haydon PG, 2006, PHYSIOL REV, V86, P1009, DOI 10.1152/physrev.00049.2005 | - |
dc.description.citedreference | Panatier A, 2006, CELL, V125, P775, DOI 10.1016/j.cell.2006.02.051 | - |
dc.description.citedreference | Xie L, 2006, TRAFFIC, V7, P429, DOI 10.1111/j.1600-0854.2006.00401.x | - |
dc.description.citedreference | Crippa D, 2006, J PHYSIOL-LONDON, V570, P567, DOI 10.1113/jphysiol.2005.094052 | - |
dc.description.citedreference | Huh YH, 2006, BIOCHEMISTRY-US, V45, P1212, DOI 10.1021/bi051594r | - |
dc.description.citedreference | FELLIN T, 2006, NOVART FDN SYMP, V276, P208 | - |
dc.description.citedreference | Kang N, 2005, J NEUROPHYSIOL, V94, P4121, DOI 10.1152/jn.00448.2005 | - |
dc.description.citedreference | Chen XK, 2005, J NEUROSCI, V25, P9236, DOI 10.1523/JNEUROSCI.1640-05.2005 | - |
dc.description.citedreference | Huh YH, 2005, FEBS LETT, V579, P5145, DOI 10.1016/j.febslet.2005.08.025 | - |
dc.description.citedreference | Perea G, 2005, CELL CALCIUM, V38, P375, DOI 10.1016/j.ceca.2005.06.015 | - |
dc.description.citedreference | Volterra A, 2005, NAT REV NEUROSCI, V6, P626, DOI 10.1038/nrn1722 | - |
dc.description.citedreference | Huh YH, 2005, FEBS LETT, V579, P2597 | - |
dc.description.citedreference | Huh YH, 2005, BIOCHEMISTRY-US, V44, P6122, DOI 10.1021/bi048070w | - |
dc.description.citedreference | Mothet JP, 2005, P NATL ACAD SCI USA, V102, P5606, DOI 10.1073/pnas.0408483102 | - |
dc.description.citedreference | Yoo SH, 2005, FEBS LETT, V579, P222, DOI 10.1016/j.febslet.2004.11.079 | - |
dc.description.citedreference | Angulo MC, 2004, J NEUROSCI, V24, P6920, DOI 10.1523/JNEUROSCI.0473-04.2004 | - |
dc.description.citedreference | Bezzi P, 2004, NAT NEUROSCI, V7, P613, DOI 10.1038/nn1246 | - |
dc.description.citedreference | Kreft M, 2004, GLIA, V46, P437, DOI 10.1002/glia.20018 | - |
dc.description.citedreference | Hua X, 2004, J NEUROSCI RES, V76, P86 | - |
dc.description.citedreference | Montana V, 2004, J NEUROSCI, V24, P2633, DOI 10.1523/JNEUROSCI.3770-03.2004 | - |
dc.description.citedreference | Thrower EC, 2003, J BIOL CHEM, V278, P49699, DOI 10.1074/jbc.M309307200 | - |
dc.description.citedreference | Zonta M, 2003, J PHYSIOL-LONDON, V553, P407, DOI 10.1113/jphysiol.2003.046706 | - |
dc.description.citedreference | Huh YH, 2003, J BIOL CHEM, V278, P40581, DOI 10.1074/jbc.M304942200 | - |
dc.description.citedreference | Quesada I, 2003, BIOPHYS J, V85, P963 | - |
dc.description.citedreference | Taupenot L, 2003, NEW ENGL J MED, V348, P1134 | - |
dc.description.citedreference | Krzan M, 2003, J NEUROSCI, V23, P1580 | - |
dc.description.citedreference | Coco S, 2003, J BIOL CHEM, V278, P1354, DOI 10.1074/jbc.M209454200 | - |
dc.description.citedreference | Yoo SH, 2002, J BIOL CHEM, V277, P16011, DOI 10.1074/jbc.M105594200 | - |
dc.description.citedreference | Thrower EC, 2002, J BIOL CHEM, V277, P15801, DOI 10.1074/jbc.M110139200 | - |
dc.description.citedreference | Park HY, 2002, BIOCHEMISTRY-US, V41, P1259, DOI 10.1021/bi015963 | - |
dc.description.citedreference | Yoo SH, 2001, J BIOL CHEM, V276, P45806 | - |
dc.description.citedreference | Jeremic A, 2001, J NEUROCHEM, V77, P664 | - |
dc.description.citedreference | Pasti L, 2001, J NEUROSCI, V21, P477 | - |
dc.description.citedreference | Eng LF, 2000, NEUROCHEM RES, V25, P1439 | - |
dc.description.citedreference | Yoo SH, 2000, J BIOL CHEM, V275, P30293 | - |
dc.description.citedreference | Yoo SH, 2000, TRENDS NEUROSCI, V23, P424 | - |
dc.description.citedreference | Parpura V, 2000, P NATL ACAD SCI USA, V97, P8629 | - |
dc.description.citedreference | Yoo SH, 2000, J BIOL CHEM, V275, P15067 | - |
dc.description.citedreference | Yoo SH, 2000, J BIOL CHEM, V275, P12553 | - |
dc.description.citedreference | Innocenti B, 2000, J NEUROSCI, V20, P1800 | - |
dc.description.citedreference | Araque A, 2000, J NEUROSCI, V20, P666 | - |
dc.description.citedreference | Srivastava M, 1999, P NATL ACAD SCI USA, V96, P13783 | - |
dc.description.citedreference | Calegari F, 1999, J BIOL CHEM, V274, P22539 | - |
dc.description.citedreference | Maienschein V, 1999, GLIA, V26, P233 | - |
dc.description.citedreference | Nguyen T, 1998, NATURE, V395, P908 | - |
dc.description.citedreference | Kim JH, 1998, P NATL ACAD SCI USA, V95, P2997 | - |
dc.description.citedreference | Majo G, 1998, LIFE SCI, V62, P607 | - |
dc.description.citedreference | Anouar Y, 1996, FEBS LETT, V394, P295 | - |
dc.description.citedreference | Yoo SH, 1996, J BIOL CHEM, V271, P17041 | - |
dc.description.citedreference | Gerasimenko OV, 1996, CELL, V84, P473 | - |
dc.description.citedreference | YOO SH, 1995, BIOCHEMISTRY-US, V34, P8680 | - |
dc.description.citedreference | BLONDEL O, 1995, TRENDS NEUROSCI, V18, P157 | - |
dc.description.citedreference | MARUYAMA Y, 1994, CELL CALCIUM, V16, P419 | - |
dc.description.citedreference | BLONDEL O, 1994, P NATL ACAD SCI USA, V91, P7777 | - |
dc.description.citedreference | YOO SH, 1994, J BIOL CHEM, V269, P12001 | - |
dc.description.citedreference | MARUYAMA Y, 1993, EMBO J, V12, P3017 | - |
dc.description.citedreference | FISCHERCOLBRIE R, 1993, J NEUROCHEM, V60, P2312 | - |
dc.description.citedreference | SCHIMMEL A, 1992, FEBS LETT, V314, P375 | - |
dc.description.citedreference | WINKLER H, 1992, NEUROSCIENCE, V49, P497 | - |
dc.description.citedreference | YOO SH, 1991, J BIOL CHEM, V266, P7740 | - |
dc.description.citedreference | HUTTNER WB, 1991, TRENDS BIOCHEM SCI, V16, P27 | - |
dc.description.citedreference | YOO SH, 1990, J BIOL CHEM, V265, P13446 | - |
dc.description.citedreference | FISCHERCOLBRIE R, 1990, J BIOL CHEM, V265, P9208 | - |
dc.description.citedreference | BETTICA A, 1990, J HISTOCHEM CYTOCHEM, V38, P103 | - |
dc.description.citedreference | HELLE KB, 1990, NEUROCHEM INT, V17, P165 | - |
dc.description.citedreference | GERDES HH, 1989, J BIOL CHEM, V264, P12009 | - |
dc.description.citedreference | HUTTON JC, 1989, DIABETOLOGIA, V32, P271 | - |
dc.description.citedreference | HAIGH JR, 1989, BIOCHEM J, V259, P485 | - |
dc.description.citedreference | FISCHERCOLBRIE R, 1987, ANN NY ACAD SCI, V493, P120 | - |
dc.description.citedreference | ORCI L, 1986, J CELL BIOL, V103, P2273 | - |
dc.description.citedreference | ENG LF, 1985, J NEUROIMMUNOL, V8, P203 | - |
dc.description.citedreference | ANDERSON RGW, 1985, CELL, V40, P635 | - |
dc.description.citedreference | KENNEDY PGE, 1980, LAB INVEST, V43, P342 | - |
dc.description.citedreference | WINKLER H, 1980, NEUROSCIENCE, V5, P1803 | - |
dc.description.citedreference | CASEY RP, 1977, BIOCHEMISTRY-US, V16, P972 | - |
dc.description.citedreference | JOHNSON RG, 1976, J BIOL CHEM, V251, P2189 | - |
dc.description.tc | 4 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.