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LONG-TERM OUTCOME OF GAMMA KNIFE RADIOSURGERY FOR TREATMENT OF TYPICAL TRIGEMINAL NEURALGIA
DC Field | Value | Language |
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dc.contributor.author | Han, Jung Ho | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.contributor.author | Chung, Hyun-Tai | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.contributor.author | Kim, Chae-Yong | - |
dc.contributor.author | Kim, Young-Hoon | - |
dc.contributor.author | Jeong, Sang Soon | - |
dc.contributor.author | Kim, Jin Wook | - |
dc.contributor.author | Kim, Yong Hwy | - |
dc.date.accessioned | 2012-06-14T00:23:23Z | - |
dc.date.available | 2012-06-14T00:23:23Z | - |
dc.date.issued | 2009-11-01 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS; Vol.75 3; 822-827 | ko_KR |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77054 | - |
dc.description.abstract | Purpose: To analyze the long-term outcomes of patients with typical trigeminal neuralgia treated with gamma knife radiosurgery (GKRS). Patients and Methods: A total of 62 consecutive patients with typical trigeminal neuralgia were treated with GKRS between 1998 and 2004. Of the 62 patients, 2 were lost to follow-up; the remaining 60 patients were followed for >12 months. The mean prescribed maximal dose was 79.7 Gy (range, 75-80), using a 4-mm shot. Results: Of the 60 patients, 48 were followed for >4 years. An additional 3 patients, followed for <4 years, experienced recurrent pain after a favorable initial response and were incorporated into the long-term response analysis. Of these 51 patients (mean age, 61 +/- 11 years; 37 women [72.5%]; and mean follow-up duration, 58 +/- 14 months), 46 (90.2%) responded to GKRS, as demonstrated by an improvement in their Barrow Neurological Institute pain intensity score. Of the 46 patients, 24 (52.2%) had pain recurrence. The actuarial recurrence-free survival rate was 84.8%, 76.1%, 69.6%, 63.0%, and 45.8% at 1, 2, 3, 4, and 5 years after radiosurgery, respectively. Patient age >70 years correlated with a favorable outcome in terms of pain recurrence after radiosurgery (hazard ratio, 0.125; 95% confidence interval, 0.016-0.975; p = .047) on multivariate analysis. Conclusion: GKRS seems to be an effective treatment modality for patients with typical trigeminal neuralgia considering the initial response rate; however, fewer than one-half of patients might continue to benefit from GKRS after long-term follow-up. Elderly patients might be good candidates for radiosurgery considering the long-term durability of efficacy. | ko_KR |
dc.description.sponsorship | Supported by Nuclear Research & Development Program of the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MEST) (grant code: M20090078163); the statistical analysis was supported by the Medical Research Collaborating Center, Seoul National University Hospital. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE INC | ko_KR |
dc.subject | Trigeminal neuralgia | ko_KR |
dc.subject | Radiosurgery | ko_KR |
dc.subject | Long-term outcome | ko_KR |
dc.subject | Gamma knife | ko_KR |
dc.title | LONG-TERM OUTCOME OF GAMMA KNIFE RADIOSURGERY FOR TREATMENT OF TYPICAL TRIGEMINAL NEURALGIA | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 한정호 | - |
dc.contributor.AlternativeAuthor | 김동규 | - |
dc.contributor.AlternativeAuthor | 정현태 | - |
dc.contributor.AlternativeAuthor | 백선하 | - |
dc.contributor.AlternativeAuthor | 김용휘 | - |
dc.contributor.AlternativeAuthor | 김채용 | - |
dc.contributor.AlternativeAuthor | 김진욱 | - |
dc.contributor.AlternativeAuthor | 김영훈 | - |
dc.contributor.AlternativeAuthor | 정상순 | - |
dc.identifier.doi | 10.1016/j.ijrobp.2008.11.046 | - |
dc.citation.journaltitle | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
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dc.description.tc | 12 | - |
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