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The Effect of Amantadine on Corneal Endothelium in Subjects with Parkinson`s Disease
DC Field | Value | Language |
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dc.contributor.author | Chang, Ki Cheol | - |
dc.contributor.author | Jeong, Jin Ho | - |
dc.contributor.author | Kim, Mee Kum | - |
dc.contributor.author | Wee, Won Ryang | - |
dc.contributor.author | Jeon, Beom Seok | - |
dc.contributor.author | Lee, Jin Hak | - |
dc.date.accessioned | 2012-06-18T05:36:14Z | - |
dc.date.available | 2012-06-18T05:36:14Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | OPHTHALMOLOGY; Vol.117 6; 1214-1219 | ko_KR |
dc.identifier.issn | 0161-6420 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77121 | - |
dc.description.abstract | Objective: To evaluate the effect of amantadine on corneal endothelial cells in subjects with Parkinson`s disease. Design: Cross-sectional study. Participants: A total of 169 subjects (169 eyes) taking amantadine orally for Parkinson`s disease and the same number of age-and gender-matched controls. Methods: Endothelial indices were compared between the amantadine-treated and age-matched control groups. The amantadine-treated group was divided into 3 subgroups according to the cumulative dose and duration of treatment. Endothelial changes were compared between the amantadine group and the normal control group, and among subgroups. Main Outcome Measures: Slit-lamp biomicroscopy, central corneal thickness (CCT), endothelial cell density (ECD), coefficient of variation, and hexagonality. Results: The amantadine group had significantly lower ECD (mean +/- standard error; 2662.47 +/- 29.06 vs. 2784.72 +/- 25.89, P = 0.002), lower hexagonality (56.94 +/- 1.07 vs. 60.97 +/- 0.87, P = 0.004), and greater coefficient of variation (35.59 +/- 0.57 vs. 32.66 +/- 0.52, P = 0.000) compared with the age-matched control group. Longer duration and higher cumulative dose amantadine therapy led to a greater reduction in ECD (P<0.05) compared with the normal age-matched control group. Conclusions: Amantadine is more likely to have an effect on corneal endothelial cells in a dose-dependent manner when used long-term. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE INC | ko_KR |
dc.title | The Effect of Amantadine on Corneal Endothelium in Subjects with Parkinson`s Disease | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 장기철 | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
dc.contributor.AlternativeAuthor | 김미금 | - |
dc.contributor.AlternativeAuthor | 위원량 | - |
dc.contributor.AlternativeAuthor | 이진학 | - |
dc.contributor.AlternativeAuthor | 전범석 | - |
dc.identifier.doi | 10.1016/j.ophtha.2009.10.039 | - |
dc.citation.journaltitle | OPHTHALMOLOGY | - |
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dc.description.tc | 0 | - |
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