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Suppressed CD31 Expression in Sarcoma-180 Tumors after Injection with Toxoplasma gondii Lysate Antigen in BALB/c Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pyo, Kyoung-Ho | - |
dc.contributor.author | Jung, Bong-Kwang | - |
dc.contributor.author | Chai, Jong-Yil | - |
dc.contributor.author | Shin, Eun-Hee | - |
dc.date.accessioned | 2012-06-22T08:40:54Z | - |
dc.date.available | 2012-06-22T08:40:54Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | KOREAN JOURNAL OF PARASITOLOGY; Vol.48 2; 171-174 | ko_KR |
dc.identifier.issn | 0023-4001 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77340 | - |
dc.description.abstract | The anti-tumorigenic effects of Toxoplasma gondii (RH) antigens were studied in a murine sarcoma-180 tumor model. To determine the anti-tumor effects, the reduction in tumor size and expression of CD31 (an angiogenesis marker in the tumor tissue) were examined after injection of BALB/c mice with T. gondii lysate antigen (TLA) or formalin-fixed, proliferation-inhibited, T. gondii tachyzoites. Tumors were successfully produced by an intradermal injection of sarcoma-180 cells with plain Matrigel in the mid-backs of mice. After injection with TLA or formalin-fixed T. gondii tachyzoites, the increase in tumor size and weight nearly stopped while tumor growth continued in control mice that were injected with PBS. CD31 expression in TLA-treated or formalin-fixed T. gondii-injected mice was lower than the control mice. Accordingly, the present study shows that the treatment of mice with formalin-fixed T. gondii or TLA in the murine sarcoma-180 tumor model results in a decrease of both tumor size and CD31 expression. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI | ko_KR |
dc.subject | lysate antigen | ko_KR |
dc.subject | CD31 | ko_KR |
dc.subject | sarcoma-180 | ko_KR |
dc.subject | Toxoplasma gondii | ko_KR |
dc.subject | anti-tumorigenic effect | ko_KR |
dc.title | Suppressed CD31 Expression in Sarcoma-180 Tumors after Injection with Toxoplasma gondii Lysate Antigen in BALB/c Mice | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 표경호 | - |
dc.contributor.AlternativeAuthor | 신은희 | - |
dc.contributor.AlternativeAuthor | 채종일 | - |
dc.contributor.AlternativeAuthor | 정봉광 | - |
dc.identifier.doi | 10.3347/kjp.2010.48.2.171 | - |
dc.citation.journaltitle | KOREAN JOURNAL OF PARASITOLOGY | - |
dc.description.tc | 0 | - |
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