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Caveolin-1 as a Novel Indicator of Wound-Healing Capacity in Aged Human Corneal Epithelium

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dc.contributor.authorRhim, Ji Heon-
dc.contributor.authorKim, Jae Hoon-
dc.contributor.authorYeo, Eui-Ju-
dc.contributor.authorKim, Jae Chan-
dc.contributor.authorPark, Sang Chul-
dc.date.accessioned2012-06-25T02:36:28Z-
dc.date.available2012-06-25T02:36:28Z-
dc.date.issued2010-12-
dc.identifier.citationMOLECULAR MEDICINE; Vol.16 (11-12); 527-534ko_KR
dc.identifier.issn1076-1551-
dc.identifier.urihttps://hdl.handle.net/10371/77370-
dc.description.abstractExcess caveolin-1 has been reported to play a role in age-dependent hyporesponsiveness to growth factors in vitro. Therefore, we hypothesized that caveolin-1-dependent hyporesponsiveness to growth factors in aged corneal epithelial cells might be responsible for delayed wound healing in vivo. To test this hypothesis, we evaluated corneal wound-healing time by vital staining using fluorescein after laser epithelial keratomileusis (LASEK). We compared wound-healing times in young, middle-aged and elderly patients. We also examined caveolin-1 levels and other aging markers, such as p53 and p21, in the corneal epithelium. Elderly patients generally had higher caveolin-1 levels in the corneal epithelia than young patients. There were, however, variations among individuals with increased caveolin-1 in some young patients and decreased levels in some elderly patients. Wound-healing time after LASEK correlated well with the corneal caveolin-1 status. Therefore, we suggest that caveolin-1 status might be responsible for delayed wound healing in elderly patients after LASEK. Caveolin-1 status might be a regulator for wound-healing capacity and a novel target for in vivo adjustment. (C) 2010 The Feinstein Institute for Medical Research, www.feinsteininstitute.orgko_KR
dc.language.isoenko_KR
dc.publisherFEINSTEIN INST MED RESko_KR
dc.titleCaveolin-1 as a Novel Indicator of Wound-Healing Capacity in Aged Human Corneal Epitheliumko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor임지헌-
dc.contributor.AlternativeAuthor김재훈-
dc.contributor.AlternativeAuthor여의주-
dc.contributor.AlternativeAuthor김재찬-
dc.contributor.AlternativeAuthor박상철-
dc.identifier.doi10.2119/molmed.2010.00046-
dc.citation.journaltitleMOLECULAR MEDICINE-
dc.description.citedreferenceGuillon M, 2010, CONTACT LENS ANTERIO, V33, P171, DOI 10.1016/j.clae.2010.03.002-
dc.description.citedreferenceMaissa C, 2010, CONTACT LENS ANTERIO, V33, P176, DOI 10.1016/j.clae.2010.02.003-
dc.description.citedreferenceMeduri A, 2009, OPHTHALMOLOGICA, V223, P139, DOI 10.1159/000187686-
dc.description.citedreferenceHos D, 2008, EXP EYE RES, V87, P427, DOI 10.1016/j.exer.2008.07.013-
dc.description.citedreferenceMimura T, 2006, INVEST OPHTH VIS SCI, V47, P1387, DOI 10.1167/iovs.05-1199-
dc.description.citedreferenceHardman MJ, 2005, AM J PATHOL, V167, P1561-
dc.description.citedreferenceFujita Y, 2004, KIDNEY INT, V66, P1794-
dc.description.citedreferenceCho KA, 2004, J BIOL CHEM, V279, P42270, DOI 10.1074/jbc.M402352200-
dc.description.citedreferencePark SC, 2004, ANN NY ACAD SCI, V1019, P309, DOI 10.1196/annals.1297.052-
dc.description.citedreferenceKuo YR, 2004, LASER SURG MED, V34, P104, DOI 10.1002/lsm.10206-
dc.description.citedreferenceCho KA, 2003, J BIOL CHEM, V278, P27789, DOI 10.1074/jbc.M208105200-
dc.description.citedreferenceYeo EJ, 2002, MECH AGEING DEV, V123, P1563-
dc.description.citedreferenceYeo EJ, 2002, EXP GERONTOL, V37, P871-
dc.description.citedreferenceBaldwin HC, 2002, ACTA OPHTHALMOL SCAN, V80, P238-
dc.description.citedreferencePark WY, 2000, J BIOL CHEM, V275, P20847-
dc.description.citedreferenceMarcus JR, 2000, PLAST RECONSTR SURG, V105, P1591-
dc.description.citedreferenceKe TL, 1999, J OCUL PHARMACOL TH, V15, P513-
dc.description.citedreferenceKo YG, 1999, J IMMUNOL, V162, P7217-
dc.description.citedreferenceAgren MS, 1999, J INVEST DERMATOL, V112, P463-
dc.description.citedreferenceKo YG, 1998, J CELL BIOCHEM, V71, P524-
dc.description.citedreferenceEngelman JA, 1998, AM J HUM GENET, V63, P1578-
dc.description.citedreferenceHe TC, 1998, P NATL ACAD SCI USA, V95, P2509-
dc.description.citedreferenceCouet J, 1997, J BIOL CHEM, V272, P30429-
dc.description.citedreferenceGarciaCardena G, 1997, J BIOL CHEM, V272, P25437-
dc.description.citedreferenceEngelman JA, 1997, J BIOL CHEM, V272, P16374-
dc.description.citedreferenceLi SW, 1996, J BIOL CHEM, V271, P29182-
dc.description.citedreferenceStrigini L, 1996, CLIN DERMATOL, V14, P197-
dc.description.citedreferenceMCFARLANE S, 1995, NEURON, V15, P1017-
dc.description.citedreferenceSARGIACOMO M, 1995, P NATL ACAD SCI USA, V92, P9407-
dc.description.citedreferenceSPINDLER KP, 1995, CONNECT TISSUE RES, V31, P171-
dc.description.citedreferenceJAGER MJ, 1995, TRANSPL IMMUNOL, V3, P135-
dc.description.citedreferenceLOGAN A, 1992, BRAIN RES, V587, P216-
dc.description.citedreferenceSCHULTZ G, 1991, J CELL BIOCHEM, V45, P346-
dc.description.citedreferenceMARSHALL J, 1988, OPHTHALMOLOGY, V95, P1411-
dc.description.citedreferenceARONROSA DS, 1986, J CATARACT REFR SURG, V12, P27-
dc.description.citedreferenceKULSHRESTHA O, 1984, INDIAN J OPHTHALMOL, V32, P454-
dc.description.tc2-
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