Publications
Detailed Information
HLA-DPB1 and DPB2 Are Genetic Loci for Systemic Sclerosis - A Genome-Wide Association Study in Koreans With Replication in North Americans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhou, Xiaodong | - |
dc.contributor.author | Lee, Jong Eun | - |
dc.contributor.author | Arnett, Frank C. | - |
dc.contributor.author | Xiong, Momiao | - |
dc.contributor.author | Yoo, Yeon Kyeong | - |
dc.contributor.author | Reveille, John D. | - |
dc.contributor.author | Kim, Jin Hyun | - |
dc.contributor.author | Choi, Ji Yong | - |
dc.contributor.author | Lee, Yun Jong | - |
dc.contributor.author | Lee, Eun Bong | - |
dc.contributor.author | Song, Yeong Wook | - |
dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Park, Ji Ah | - |
dc.contributor.author | Song, Ran | - |
dc.contributor.author | Mayes, Maureen D. | - |
dc.contributor.author | Shin, Eun Soon | - |
dc.contributor.author | Park, Min Young | - |
dc.date.accessioned | 2012-06-25T06:02:58Z | - |
dc.date.available | 2012-06-25T06:02:58Z | - |
dc.date.issued | 2009-12 | - |
dc.identifier.citation | ARTHRITIS AND RHEUMATISM; Vol.60 12; 3807-3814 | ko_KR |
dc.identifier.issn | 0004-3591 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77393 | - |
dc.description.abstract | Objective. To identify systemic sclerosis (SSc) susceptibility loci via a genome-wide association study. Methods. A genome-wide association study was performed in 137 patients with SSc and 564 controls from Korea using the Affymetrix Human SNP Array 5.0. After fine-mapping studies, the results were replicated in 1,107 SSc patients and 2,747 controls from a US Caucasian population. Results. The single-nucleotide polymorphisms (SNPs) (rs3128930, rs7763822, rs7764491, rs3117230, and rs3128965) of HLA-DPB1. and DPB2 on chromosome 6 formed a distinctive peak with log P values for association with SSc susceptibility (P = 8.16 X 10(-13)). Subtyping analysis of HLA-DPB1 showed that DPB1*1301 (P = 7.61 x 10(-8)) and DPB1*0901. (P = 2.55 x 10(-5)) were the subtypes most susceptible to SSc in Korean subjects. In US Caucasians, 2 pairs of SNPs, rs7763822/rs7764491 and rs3117230/rs3128965, showed strong association with SSc patients who had either circulating anti-DNA topoisomerase I (P = 7.58 x 10(-17)/4.84 x 10(-16)) or anticentromere autoantibodies (P = 1.12 x 10(-3)/3.2 x 10(-5)), respectively. Conclusion. The results of our genome-wide association study in Korean subjects indicate that the region of HLA-DPB1 and DPB2 contains the loci most susceptible to SSc in a Korean population. The confirmatory studies in US Caucasians indicate that specific SNPs of HLA-DPB1 and/or DPB2 are strongly associated with US Caucasian patients with SSc who are positive for anti-DNA topoisomerase I or anticentromere autoantibodies. | ko_KR |
dc.description.sponsorship | Supported by the Korean Health 21 Research & Development
Project, the Ministry of Health, Welfare, and Family Affairs, Republic of Korea (grant A030001); the NIH (grants P50-AR-054144, NO1-AR-02251, and UL1-RR-024148 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases), and the US Department of the Army, Medical Research Acquisition Activity (grants PR-064803 and PR-064851). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-LISS | ko_KR |
dc.title | HLA-DPB1 and DPB2 Are Genetic Loci for Systemic Sclerosis - A Genome-Wide Association Study in Koreans With Replication in North Americans | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이종은 | - |
dc.contributor.AlternativeAuthor | 박민영 | - |
dc.contributor.AlternativeAuthor | 유연경 | - |
dc.contributor.AlternativeAuthor | 신은순 | - |
dc.contributor.AlternativeAuthor | 김진현 | - |
dc.contributor.AlternativeAuthor | 송란 | - |
dc.contributor.AlternativeAuthor | 최지용 | - |
dc.contributor.AlternativeAuthor | 박지아 | - |
dc.contributor.AlternativeAuthor | 이윤종 | - |
dc.contributor.AlternativeAuthor | 이은영 | - |
dc.contributor.AlternativeAuthor | 송영욱 | - |
dc.contributor.AlternativeAuthor | 이은봉 | - |
dc.identifier.doi | 10.1002/art.24982 | - |
dc.citation.journaltitle | ARTHRITIS AND RHEUMATISM | - |
dc.description.citedreference | Chifflot H, 2008, SEMIN ARTHRITIS RHEU, V37, P223, DOI 10.1016/j.semarthrit.2007.05.003 | - |
dc.description.citedreference | RUEDA B, 2008, ANN RHEUM DIS | - |
dc.description.citedreference | Frazer KA, 2007, NATURE, V449, P851, DOI 10.1038/nature06258 | - |
dc.description.citedreference | Fonseca C, 2007, NEW ENGL J MED, V357, P1210 | - |
dc.description.citedreference | Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795 | - |
dc.description.citedreference | Alkassab F, 2007, RHEUMATOLOGY, V46, P1248, DOI 10.1093/rheumatology/kem057 | - |
dc.description.citedreference | Gourh P, 2006, ARTHRITIS RHEUM, V54, P3945, DOI 10.1002/art.22196 | - |
dc.description.citedreference | Wipff J, 2006, ANN RHEUM DIS, V65, P1230, DOI 10.1136/ard.2005.048181 | - |
dc.description.citedreference | Viken MK, 2005, GENES IMMUN, V6, P271, DOI 10.1038/sj.gene.6364178 | - |
dc.description.citedreference | Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457 | - |
dc.description.citedreference | KORN JH, 2005, ARTHRITIS ALLIED CON, P1621 | - |
dc.description.citedreference | Kyogoku C, 2004, AM J HUM GENET, V75, P504 | - |
dc.description.citedreference | Cruz TD, 2004, DIABETES, V53, P2158 | - |
dc.description.citedreference | Tikly M, 2004, TISSUE ANTIGENS, V63, P487 | - |
dc.description.citedreference | Lee EB, 2004, TISSUE ANTIGENS, V63, P491 | - |
dc.description.citedreference | Thomas DC, 2004, J NATL CANCER I, V96, P421, DOI 10.1093/jnci/djh094 | - |
dc.description.citedreference | Mayes MD, 2003, ARTHRITIS RHEUM, V48, P2246, DOI 10.1002/art.11073 | - |
dc.description.citedreference | Sugiura Y, 2003, J RHEUMATOL, V30, P1520 | - |
dc.description.citedreference | Shaw BE, 2003, BONE MARROW TRANSPL, V31, P1001, DOI 10.1038/sj.bmt.1704029 | - |
dc.description.citedreference | McCanlies EC, 2003, AM J EPIDEMIOL, V157, P388, DOI 10.1093/aje/kwg001 | - |
dc.description.citedreference | Crilly A, 2002, ANN RHEUM DIS, V61, P678 | - |
dc.description.citedreference | TAKEUCHI F, 2002, CLIN EXP RHEUMATOL, V20, P823 | - |
dc.description.citedreference | Gilchrist FC, 2001, GENES IMMUN, V2, P76 | - |
dc.description.citedreference | Pandey JP, 1999, HUM IMMUNOL, V60, P1128 | - |
dc.description.citedreference | Bunn CC, 1999, CLIN EXP IMMUNOL, V117, P207 | - |
dc.description.citedreference | Kuwana M, 1999, INTERNAL MED, V38, P336 | - |
dc.description.citedreference | Lympany PA, 1996, EUR J IMMUNOGENET, V23, P353 | - |
dc.description.citedreference | Rihs HP, 1996, INT ARCH ALLERGY IMM, V109, P216 | - |
dc.description.citedreference | RICHELDI L, 1993, SCIENCE, V262, P242 | - |
dc.description.citedreference | REVEILLE JD, 1992, TISSUE ANTIGENS, V40, P45 | - |
dc.description.citedreference | BEGOVICH AB, 1992, J IMMUNOL, V148, P249 | - |
dc.description.citedreference | BEGOVICH AB, 1989, P NATL ACAD SCI USA, V86, P9489 | - |
dc.description.citedreference | LEROY EC, 1988, J RHEUMATOL, V15, P202 | - |
dc.description.citedreference | JARZABEKCHORZELSKA M, 1986, BRIT J DERMATOL, V115, P393 | - |
dc.description.citedreference | LACHIN JM, 1981, CONTROL CLIN TRIALS, V2, P93 | - |
dc.description.citedreference | *SUBC SCLER CRIT A, 1980, ARTHRITIS RHEUM, V23, P581 | - |
dc.description.citedreference | MOROI Y, 1980, P NATL ACAD SCI-BIOL, V77, P1627 | - |
dc.description.tc | 16 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.