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Efficacy and Toxicity of Pemetrexed as a Third-line Treatment for Non-small Cell Lung Cancer

Cited 33 time in Web of Science Cited 40 time in Scopus
Authors
Sun, Jong-Mu; Lee, Keun-Wook; Kim, Jee Hyun; Kim, Yu Jung; Lee, Jae-Ho; Lee, Jong Seok; Lee, Choon-Taek; Yoon, Ho Il
Issue Date
2009-01
Publisher
OXFORD UNIV PRESS
Citation
JAPANESE JOURNAL OF CLINICAL ONCOLOGY; Vol.39 1; 27-32
Keywords
non-small cell lung cancersecond-linethird-linepemetrexed
Abstract
Pemetrexed has been approved for second-line treatment in non-small cell lung cancer (NSCLC). However, the role of third-line pemetrexed therapy in NSCLC has not yet been generally accepted. We attempted to validate third-line pemetrexed therapy and evaluate predictive factors for pemetrexed therapy for NSCLC. Medical records of NSCLC patients who received pemetrexed therapy that progressed after systemic therapy were reviewed retrospectively. We stratified patients according to clinicopathologic characteristics to find predictive factors for pemetrexed therapy. A total of 100 patients were eligible for analysis, and overall progression-free survival (PFS) was 3.03 months. The objective response rate was 12%, and the toxicity profile was favorable. Pemetrexed was used as a second-line treatment in 30% of patients, and as third- or further-line treatment in 70%. Comparing the efficacy of pemetrexed in these two settings (second-line versus third- or further-line), there was no significant difference in terms of PFS (3.07 versus 2.83 months, P = 0.86). When we evaluated predictive factors by multivariate analysis, performance status significantly influenced PFS. Pemetrexed is a suitable third-line treatment option with good efficacy and tolerable toxicity profile for NSCLC.
ISSN
0368-2811
Language
English
URI
http://hdl.handle.net/10371/77403
DOI
https://doi.org/10.1093/jjco/hyn118
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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