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Detection of Differential Proteomes of Human beta-Cells During Islet-Like Differentiation Using iTRAQ Labeling
DC Field | Value | Language |
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dc.contributor.author | Jin, Jonghwa | - |
dc.contributor.author | Park, Jungeun | - |
dc.contributor.author | Kim, Kyunggon | - |
dc.contributor.author | Kang, Yup | - |
dc.contributor.author | Kim, Jae Hyeon | - |
dc.contributor.author | Jun, Heesook | - |
dc.contributor.author | Kim, Youngsoo | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Park, Sang Gyu | - |
dc.date.accessioned | 2012-06-26T00:23:20Z | - |
dc.date.available | 2012-06-26T00:23:20Z | - |
dc.date.issued | 2009-03 | - |
dc.identifier.citation | JOURNAL OF PROTEOME RESEARCH; Vol.8 3; 1393-1403 | ko_KR |
dc.identifier.issn | 1535-3893 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77409 | - |
dc.description.abstract | A human beta-cell line, RNAKT-15, was recently established from human pancreatic islets, whereby its differentiation into islet-like beta-cells (islet-like RNAKT-15) increased its expression of insulin 2-fold compared with RNAKT-15 cells. To characterize the differentiation of RNAKT-15 cells into islet-like RNAKT-15, microarray and quantitative proteomics were performed. Our analysis of differential proteomic and mRNA expression has resulted in a greater understanding of the molecular functions that are involved in beta-cell differentiation and insulin synthesis and release. | ko_KR |
dc.description.sponsorship | This work was supported by the
21C Frontier Functional Proteomics Project of the Korean Ministry of Science and Technology (grant no. FPR 08-A2-110) and by a grant of the Korea Health 21 R&D Project, Ministry for Health, Welfare and Family Affairs, ROK (A030003). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER CHEMICAL SOC | ko_KR |
dc.subject | human beta-cell line | ko_KR |
dc.subject | RNAKT-15 cell | ko_KR |
dc.subject | iTRAQ | ko_KR |
dc.subject | islet transplantation | ko_KR |
dc.subject | beta-cell differentiation | ko_KR |
dc.title | Detection of Differential Proteomes of Human beta-Cells During Islet-Like Differentiation Using iTRAQ Labeling | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 진종화 | - |
dc.contributor.AlternativeAuthor | 박정은 | - |
dc.contributor.AlternativeAuthor | 김경곤 | - |
dc.contributor.AlternativeAuthor | 강엽 | - |
dc.contributor.AlternativeAuthor | 박상규 | - |
dc.contributor.AlternativeAuthor | 김재현 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.contributor.AlternativeAuthor | 전희숙 | - |
dc.contributor.AlternativeAuthor | 김영수 | - |
dc.identifier.doi | 10.1021/pr800765t | - |
dc.citation.journaltitle | JOURNAL OF PROTEOME RESEARCH | - |
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dc.description.tc | 9 | - |
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