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Differential role of mesangial cells and podocytes in TGF-beta-induced mesangial matrix synthesis in chronic glomerular disease
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun Soon | - |
dc.contributor.author | Song, Chi Young | - |
dc.date.accessioned | 2012-06-26T05:21:55Z | - |
dc.date.available | 2012-06-26T05:21:55Z | - |
dc.date.issued | 2009-07 | - |
dc.identifier.citation | HISTOLOGY AND HISTOPATHOLOGY; Vol.24 7; 901-908 | ko_KR |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77429 | - |
dc.description.abstract | Glomerulosclerosis is characterized by mesangial matrix accumulation that is mediated primarily by activation of transforming growth factor-beta (TGF-beta). Unlike podocytes, mesangial cells secrete TGF-beta in response to common in vitro fibrogenic stimuli. However, mesangial immunostaining for active TGF-beta 1 in chronic glomerular disease is almost negligible, despite increased mesangial TGF-beta 1 mRNA expression, while podocytes covering the sclerotic glomerular segments exhibit increased TGF-beta 1 protein expression. The mechanisms whereby TGF-beta is activated in the diseased glomeruli and how the activated TGF-beta leads to mesangial matrix overproduction are not clear. We provide evidence that TGF-beta secreted as latent complexes by mesangial cells is stored in the mesangial matrix, from which soluble forms of latent TGF-beta are released and localized to the podocyte surface in chronic glomerular disease. Podocyte-derived reactive oxygen species, plasmin and thrombospondin-1, particularly renin-angiotensin-aldosterone system-induced oxidative stress, seem to be involved in TGF-beta activation in podocytes. We also provide evidence that the TGF-beta-induced secretion of connective tissue growth factor and vascular endothelial growth factor by podocytes acts as a paracrine regulatory mechanism on mesangial cells, which may cause mesangial matrix accumulation culminating in the development of glomerulosclerosis. Collectively, these data bring new insights into our understanding of the roles of the mesangial cells and podocytes in the TGF-beta-induced mesangial matrix synthesis in chronic glomerular disease. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | F HERNANDEZ | ko_KR |
dc.subject | Chronic glomerular disease | ko_KR |
dc.subject | TGF-beta activation | ko_KR |
dc.subject | Podocytes | ko_KR |
dc.subject | Glomerulosclerosis | ko_KR |
dc.subject | Mesangial matrix | ko_KR |
dc.title | Differential role of mesangial cells and podocytes in TGF-beta-induced mesangial matrix synthesis in chronic glomerular disease | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이현순 | - |
dc.contributor.AlternativeAuthor | 송치영 | - |
dc.citation.journaltitle | HISTOLOGY AND HISTOPATHOLOGY | - |
dc.description.citedreference | Lee HS, 2009, AM J NEPHROL, V29, P62, DOI 10.1159/000151277 | - |
dc.description.citedreference | Nguyen TQ, 2008, J AM SOC NEPHROL, V19, P2098, DOI 10.1681/ASN.2007111261 | - |
dc.description.citedreference | Zheng SR, 2008, J AM SOC NEPHROL, V19, P2077, DOI 10.1681/ASN.2007080967 | - |
dc.description.citedreference | Katavetin P, 2008, NEW ENGL J MED, V359, P205 | - |
dc.description.citedreference | Whaley-Connell A, 2008, HYPERTENSION, V51, P474 | - |
dc.description.citedreference | Yokoi H, 2008, KIDNEY INT, V73, P446, DOI 10.1038/sj.ki.5002722 | - |
dc.description.citedreference | Koli K, 2008, ANTIOXID REDOX SIGN, V10, P333, DOI 10.1089/ars.2007.1914 | - |
dc.description.citedreference | ZIYADEH FN, 2008, CURR DIABETES REV, V4, P39 | - |
dc.description.citedreference | Daniel C, 2007, DIABETES, V56, P2982, DOI 10.2337/db07-0551 | - |
dc.description.citedreference | Xu J, 2007, AM J PHYSIOL-RENAL, V293, pF1468, DOI 10.1152/ajprenal.00246.2007 | - |
dc.description.citedreference | Cooker LA, 2007, AM J PHYSIOL-RENAL, V293, pF157, DOI 10.1152/ajprenal.00508.2006 | - |
dc.description.citedreference | Otsuka G, 2007, CIRC RES, V100, P1300, DOI 10.1161/01.RES.000026670.34017.8d | - |
dc.description.citedreference | Gianella A, 2007, AM J PATHOL, V170, P1165, DOI 10.2353/ajpath.2007.060882 | - |
dc.description.citedreference | Shibata S, 2007, HYPERTENSION, V49, P355, DOI 10.1161/01.HYP.0000255636.11931.a2 | - |
dc.description.citedreference | Jobling ME, 2006, RADIAT RES, V166, P839 | - |
dc.description.citedreference | Whaley-Connell AT, 2006, AM J PHYSIOL-RENAL, V291, pF1308, DOI 10.1152/ajprenal.00167.2006 | - |
dc.description.citedreference | Sung SH, 2006, J AM SOC NEPHROL, V17, P3093, DOI 10.1681/ASN.2006010064 | - |
dc.description.citedreference | Wang SN, 2006, J AM SOC NEPHROL, V17, P2504, DOI 10.1681/ASN.2006030278 | - |
dc.description.citedreference | Nagase M, 2006, HYPERTENSION, V47, P1084, DOI 10.1161/01.HYP.0000222003.28517.99 | - |
dc.description.citedreference | Ostendorf T, 2006, J AM SOC NEPHROL, V17, P1054, DOI 10.1681/ASN.2005070683 | - |
dc.description.citedreference | Porst M, 2006, NEPHRON EXP NEPHROL, V102, pE99, DOI 10.1159/000089688 | - |
dc.description.citedreference | Chow EK, 2005, EMBO J, V24, P4071, DOI 10.1038/sj.emboj.7600867 | - |
dc.description.citedreference | Wahab NA, 2005, DIABETOLOGIA, V48, P2650, DOI 10.1007/s00125-005-0006-5 | - |
dc.description.citedreference | Chen SD, 2005, NEPHROL DIAL TRANSPL, V20, P1320, DOI 10.1093/ndt/gfh837 | - |
dc.description.citedreference | Wolf G, 2005, DIABETES, V54, P1626 | - |
dc.description.citedreference | Matsusaka T, 2005, J AM SOC NEPHROL, V16, P1013 | - |
dc.description.citedreference | George SJ, 2005, J VASC RES, V42, P247, DOI 10.1159/000085657 | - |
dc.description.citedreference | Yu L, 2004, KIDNEY INT, V66, P1774 | - |
dc.description.citedreference | Liu N, 2004, AM J PHYSIOL-RENAL, V287, pF612, DOI 10.1152/ajprenal.00322.2003 | - |
dc.description.citedreference | Trevillian P, 2004, KIDNEY INT, V66, P1423 | - |
dc.description.citedreference | Wang L, 2004, J BIOL CHEM, V279, P33213, DOI 10.1074/jbc.M403758200 | - |
dc.description.citedreference | Edgtton KL, 2004, KIDNEY INT, V66, P68 | - |
dc.description.citedreference | Annes JP, 2004, J CELL BIOL, V165, P723, DOI 10.1083/jcb.200312172 | - |
dc.description.citedreference | Durvasula RV, 2004, KIDNEY INT, V65, P30 | - |
dc.description.citedreference | Hyytiainen M, 2004, CRIT REV CL LAB SCI, V41, P233, DOI 10.1080/10408360490460933 | - |
dc.description.citedreference | Kim JH, 2003, KIDNEY INT, V64, P1715 | - |
dc.description.citedreference | Kanemoto K, 2003, LAB INVEST, V83, P1615, DOI 10.1097/01.LAB.0000096711.58115.46 | - |
dc.description.citedreference | Baricos WH, 2003, EXP BIOL MED, V228, P1018 | - |
dc.description.citedreference | Patek CE, 2003, HUM MOL GENET, V12, P2379, DOI 10.1093/hmg/ddg240 | - |
dc.description.citedreference | Daniel C, 2003, AM J PATHOL, V163, P1185 | - |
dc.description.citedreference | Benigni A, 2003, J AM SOC NEPHROL, V14, P1816, DOI 10.1097/01.ASN.0000074238.61967.B7 | - |
dc.description.citedreference | Wendt TM, 2003, AM J PATHOL, V162, P1123 | - |
dc.description.citedreference | Weston BS, 2003, J AM SOC NEPHROL, V14, P601, DOI 10.1097/01.ASN.0000051600.53134.B9 | - |
dc.description.citedreference | Annes JP, 2003, J CELL SCI, V116, P217, DOI 10.1242/jcs.00229 | - |
dc.description.citedreference | Hartner A, 2003, J MOL MED-JMM, V81, P32, DOI 10.1007/s00109-002-0403-x | - |
dc.description.citedreference | Abbate M, 2002, AM J PATHOL, V161, P2179 | - |
dc.description.citedreference | Chiba Y, 2002, J HYPERTENS, V20, P2269, DOI 10.1097/00004872-200211000-00027 | - |
dc.description.citedreference | Flyvbjerg A, 2002, DIABETES, V51, P3090, DOI 10.2337/diabetes.51.10.3090 | - |
dc.description.citedreference | Chen YJ, 2002, KIDNEY INT, V62, P1149 | - |
dc.description.citedreference | Gore-Hyer E, 2002, AM J PHYSIOL-RENAL, V283, pF707, DOI 10.1152/ajprenal.00007.2002 | - |
dc.description.citedreference | Hashimoto G, 2002, J BIOL CHEM, V277, P36288, DOI 10.1074/jbc.M201674200 | - |
dc.description.citedreference | Iglesias-de la Cruz MC, 2002, KIDNEY INT, V62, P901 | - |
dc.description.citedreference | Abreu JG, 2002, NAT CELL BIOL, V4, P599, DOI 10.1038/ncb826 | - |
dc.description.citedreference | Kim HW, 2002, NEPHROLOGY, V7, pS131 | - |
dc.description.citedreference | Mu DZ, 2002, J CELL BIOL, V157, P493 | - |
dc.description.citedreference | Ostendorf T, 2002, J AM SOC NEPHROL, V13 | - |
dc.description.citedreference | Deen WM, 2001, AM J PHYSIOL-RENAL, V281, pF579 | - |
dc.description.citedreference | Lee HS, 2001, HISTOPATHOLOGY, V39, P203 | - |
dc.description.citedreference | Blom IE, 2001, NEPHROL DIAL TRANSPL, V16, P1139 | - |
dc.description.citedreference | Lawrence DA, 2001, MOL CELL BIOCHEM, V219, P163 | - |
dc.description.citedreference | Ito Y, 2001, J AM SOC NEPHROL, V12, P472 | - |
dc.description.citedreference | Koli K, 2001, MICROSC RES TECHNIQ, V52, P354 | - |
dc.description.citedreference | Grainger DJ, 2000, BIOCHEM J, V350, P291 | - |
dc.description.citedreference | Ziyadeh FN, 2000, P NATL ACAD SCI USA, V97, P8015 | - |
dc.description.citedreference | Abdelouahed M, 2000, J BIOL CHEM, V275, P17933 | - |
dc.description.citedreference | Yamabe H, 2000, NEPHROL DIAL TRANSPL, V15, P872 | - |
dc.description.citedreference | Nakagawa H, 2000, DIABETES RES CLIN PR, V48, P87 | - |
dc.description.citedreference | Hill C, 2000, ENDOCRINOLOGY, V141, P1196 | - |
dc.description.citedreference | Yu Q, 2000, GENE DEV, V14, P163 | - |
dc.description.citedreference | Riser BL, 2000, J AM SOC NEPHROL, V11, P25 | - |
dc.description.citedreference | Munger JS, 1999, CELL, V96, P319 | - |
dc.description.citedreference | Crawford SE, 1998, CELL, V93, P1159 | - |
dc.description.citedreference | Ito Y, 1998, KIDNEY INT, V53, P853 | - |
dc.description.citedreference | Hugo C, 1998, KIDNEY INT, V53, P302 | - |
dc.description.citedreference | Mundel P, 1997, EXP CELL RES, V236, P248 | - |
dc.description.citedreference | SteinOakley AN, 1997, KIDNEY INT, V51, P195 | - |
dc.description.citedreference | BarcellosHoff MH, 1996, MOL ENDOCRINOL, V10, P1077 | - |
dc.description.citedreference | Kopp JB, 1996, LAB INVEST, V74, P991 | - |
dc.description.citedreference | TAIPALE J, 1992, J BIOL CHEM, V267, P25378 | - |
dc.description.citedreference | WAKEFIELD LM, 1990, J CLIN INVEST, V86, P1976 | - |
dc.description.citedreference | LYONS RM, 1990, J CELL BIOL, V110, P1361 | - |
dc.description.citedreference | COFFEY RJ, 1987, J CLIN INVEST, V80, P750 | - |
dc.description.tc | 10 | - |
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