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Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics
DC Field | Value | Language |
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dc.contributor.author | Kim, Jin-Moo | - |
dc.contributor.author | Park, Byung-Lae | - |
dc.contributor.author | Park, Se-Min | - |
dc.contributor.author | Lee, Shin-Hwa | - |
dc.contributor.author | Jung, Seok | - |
dc.contributor.author | Uh, Soo-Taek | - |
dc.contributor.author | Choi, Jae-Sung | - |
dc.contributor.author | Kim, Mi-Kyeong | - |
dc.contributor.author | Cho, Sang Heon | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Chang, Hun Soo | - |
dc.contributor.author | Park, Hae-Sim | - |
dc.contributor.author | Choi, Byoung Whui | - |
dc.contributor.author | Choi, Inseon S. | - |
dc.contributor.author | Kim, Yong-Hoon | - |
dc.contributor.author | Park, Jong Sook | - |
dc.contributor.author | Lee, Eun Hee | - |
dc.contributor.author | Kim, Myung-Ok | - |
dc.date.accessioned | 2012-06-26T05:41:19Z | - |
dc.date.available | 2012-06-26T05:41:19Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.citation | PHARMACOGENOMICS; Vol.11 7; 951-958 | ko_KR |
dc.identifier.issn | 1462-2416 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77436 | - |
dc.description.abstract | Aims: Cysteinyl leukotrienes are inactivated by acetyl coenzyme A-dependent N-acetyltransferase (NAT). Thus, functional alterations of the NAT gene may contribute to the risk of aspirin-intolerant asthma. Materials & methods: Asthmatics (n = 438) were categorized into aspirin-intolerant asthma (15% or greater decrease in the forced expiratory volume in 1 s or cutaneous reactions, n = 170) or aspirin-tolerant asthma (n = 268) groups. In total, 14 polymorphisms of the NAT2 gene were genotyped by a single-base extension method. Results: The distributions of all loci of the 14 SNPs were in Hardy-Weinberg equilibrium (p > 0.05). Among the 14 SNPs, six common SNPs (minor allele frequency >5%) in a Korean population were used for haplotype construction and further statistical analysis. The logistic regression analysis demonstrated that NAT2 -9246G>C and haplotype 2 (TCACGG) were significantly associated with the risk of aspirin-intolerant asthma. The rare allele frequencies of the SNP and Ht2 were significantly higher in the aspirin-intolerant asthma group than in the aspirin-tolerant asthma group (pwrr = 0.03 and IV)" = 0.02 in codominant model). Conclusion: In a large genetic epidemiology study of aspirin-intolerant asthma in a Korean population, genetic polymorphisms of NAT2 were found to be related to a risk of aspirin hypersensitivity among asthmatics. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | FUTURE MEDICINE LTD | ko_KR |
dc.subject | arylamine N-acetyltransferase | ko_KR |
dc.subject | aspirin-induced asthma | ko_KR |
dc.subject | cysteinyl leukotriene | ko_KR |
dc.subject | SNP | ko_KR |
dc.title | Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김진무 | - |
dc.contributor.AlternativeAuthor | 박병래 | - |
dc.contributor.AlternativeAuthor | 박세민 | - |
dc.contributor.AlternativeAuthor | 이신화 | - |
dc.contributor.AlternativeAuthor | 김명옥 | - |
dc.contributor.AlternativeAuthor | 정석 | - |
dc.contributor.AlternativeAuthor | 이은희 | - |
dc.contributor.AlternativeAuthor | 어수택 | - |
dc.contributor.AlternativeAuthor | 박종숙 | - |
dc.contributor.AlternativeAuthor | 최재성 | - |
dc.contributor.AlternativeAuthor | 김용훈 | - |
dc.contributor.AlternativeAuthor | 김미경 | - |
dc.contributor.AlternativeAuthor | 최인선 | - |
dc.contributor.AlternativeAuthor | 조상헌 | - |
dc.contributor.AlternativeAuthor | 최병휘 | - |
dc.contributor.AlternativeAuthor | 박해심 | - |
dc.contributor.AlternativeAuthor | 장훈수 | - |
dc.contributor.AlternativeAuthor | 신형두 | - |
dc.contributor.AlternativeAuthor | 박준식 | - |
dc.identifier.doi | 10.2217/PGS.10.65 | - |
dc.citation.journaltitle | PHARMACOGENOMICS | - |
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dc.description.tc | 1 | - |
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