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Multiplex genotyping of 1107 SNPs from 232 candidate genes identified an association between IL1A polymorphism and breast cancer risk
DC Field | Value | Language |
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dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Kang, So Young | - |
dc.contributor.author | Kang, Daehee | - |
dc.contributor.author | Park, Sue K. | - |
dc.contributor.author | Kim, Ho | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Park, Ae Kyung | - |
dc.contributor.author | Lee, Ji-Young | - |
dc.date.accessioned | 2012-06-27T04:51:29Z | - |
dc.date.available | 2012-06-27T04:51:29Z | - |
dc.date.issued | 2010-03 | - |
dc.identifier.citation | ONCOLOGY REPORTS; Vol.23 3; 763-769 | ko_KR |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://hdl.handle.net/10371/77558 | - |
dc.description.abstract | We sought to identify genes and polymorphisms associated with breast cancer risk among Korean women using Multiplex genotyping. The SNPs (n=1536) of 264 candidate genes were genotyped using the Illumina Golden Gate (TM) assay. These genes are involved in the pathways controlling apoptosis/anti-apoptosis, the immune and inflammatory responses, cytokines, DNA repair, cell adhesion, and cell cycle/proliferation. Breast cancer cases (n=209) were recruited front Seoul National University Hospital. Age-matched control subjects (n=209) were selected from a health examinees cohort. Gene-based and SNP-based tests were performed. The final analysis includes 117 cases and 164 controls with 1107 SNPs in 232 genes. Gene-based analyses showed that IL1A, TNFRSF10B, TNFRSF1B, ICAM, and TNFSF9 were significantly associated with breast cancer risk (p<0.01). ILIA was the most significant gene associated with breast cancer risk [p for likelihood ratio test, I degree of freedom (df)=6x10(-7); FDR-adjusted p-value, 1 df=4x10(-4), 2df=0.0071, respectively]. Individual SNP-based analyses revealed that the rare allele of the ILIA SNP rs2856836, Ex7-592T -> C, was strongly associated with breast cancer risk (FDR-adjusted p-value, 1 df=0.0027, 2df=0.0162). This SNP was found to increase risk for breast cancer [odds ratio (OR)=2.88, 95% confidence interval (CI)= 1.58-5.27 for heterozygote and OR=8.17, 95% CI=2.23-29.99 for rare homozygote]. In summary, we identified a common genetic variant in ILIA strongly associated with breast cancer risk. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SPANDIDOS PUBL LTD | ko_KR |
dc.subject | breast cancer | ko_KR |
dc.subject | risk | ko_KR |
dc.subject | IL1A | ko_KR |
dc.subject | multiplex genotyping | ko_KR |
dc.subject | polymorphism | ko_KR |
dc.title | Multiplex genotyping of 1107 SNPs from 232 candidate genes identified an association between IL1A polymorphism and breast cancer risk | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 한원식 | - |
dc.contributor.AlternativeAuthor | 강소영 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.contributor.AlternativeAuthor | 박수경 | - |
dc.contributor.AlternativeAuthor | 이지영 | - |
dc.contributor.AlternativeAuthor | 김호 | - |
dc.contributor.AlternativeAuthor | 박애경 | - |
dc.contributor.AlternativeAuthor | 노동영 | - |
dc.identifier.doi | 10.3892/or_00000696 | - |
dc.citation.journaltitle | ONCOLOGY REPORTS | - |
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