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Korean Patients with Superwarfarin Intoxication and Their Outcome
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Junshik | - |
dc.contributor.author | Yhim, Ho-Young | - |
dc.contributor.author | Bang, Soo-Mee | - |
dc.contributor.author | Bae, Sung Hwa | - |
dc.contributor.author | Yoon, Sung-Soo | - |
dc.contributor.author | Kim, Seung Taik | - |
dc.contributor.author | Chi, Hyun-Sook | - |
dc.contributor.author | Yoon, Hwi-Joong | - |
dc.contributor.author | Yuh, Young Jin | - |
dc.date.accessioned | 2012-06-27T07:27:24Z | - |
dc.date.available | 2012-06-27T07:27:24Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.25 12; 1754-1758 | ko_KR |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77628 | - |
dc.description.abstract | This observational study aimed at evaluating recent superwarfarin intoxication of Korean patients. Ten patients were diagnosed as or highly suspicious for superwarfarin intoxication. Case report forms described by attending hematologists of the patients were collected and analyzed. Bleeding symptoms were varied among the patients. Patients uniformly showed prolonged prothrombin time (PT) and activated thromboplastin time (aPTT) with decreased activity of vitamin K dependent coagulation factors. Positive serum brodifacoum test results in 4 of 5 requested patients contributed to confirmatory diagnosis. Psychiatric interview revealed an attempted ingestion in one patient. High dose vitamin K1 therapy promptly corrected prolonged PT and aPTT, but hasty discontinuation caused repeated bleeding diathesis in 6 patients. Route of intoxication was unknown or not definite among 8 of 10 patients. Three patients had a possibility of environmental exposure considering their occupations: there might be intoxication by transdermal absorption or inhalation. Therefore, high dose and prolonged use of vitamin K1 therapy is necessary for effective detoxification. Further detailed investigation on environmental exposure and efforts to improve availability of the blood level test in clinic are requested. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | ko_KR |
dc.subject | Superwarfarin | ko_KR |
dc.subject | Brodifacoum | ko_KR |
dc.subject | Rodenticides | ko_KR |
dc.subject | Vitamin K | ko_KR |
dc.title | Korean Patients with Superwarfarin Intoxication and Their Outcome | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 홍전식 | - |
dc.contributor.AlternativeAuthor | 임호영 | - |
dc.contributor.AlternativeAuthor | 방수미 | - |
dc.contributor.AlternativeAuthor | 배성화 | - |
dc.contributor.AlternativeAuthor | 유영진 | - |
dc.contributor.AlternativeAuthor | 윤성수 | - |
dc.contributor.AlternativeAuthor | 윤휘중 | - |
dc.contributor.AlternativeAuthor | 김승택 | - |
dc.contributor.AlternativeAuthor | 지현숙 | - |
dc.identifier.doi | 10.3346/jkms.2010.25.12.1754 | - |
dc.citation.journaltitle | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
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dc.description.tc | 0 | - |
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