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Serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia induced by intra-amniotic lipopolysaccharide and postnatal hyperoxia
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Choi, Chang Won | - |
dc.contributor.author | Kim, Beyong Il | - |
dc.contributor.author | Kim, Ee-Kyung | - |
dc.contributor.author | Choi, Jung-Hwan | - |
dc.contributor.author | Yang, Eun Gyeong | - |
dc.contributor.author | Lee, Myong Jin | - |
dc.contributor.author | Kim, Han-Suk | - |
dc.date.accessioned | 2012-06-28T02:14:28Z | - |
dc.date.available | 2012-06-28T02:14:28Z | - |
dc.date.issued | 2010-11 | - |
dc.identifier.citation | JOURNAL OF PERINATAL MEDICINE; Vol.38(6); 675-681 | ko_KR |
dc.identifier.issn | 0300-5577 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77726 | - |
dc.description.abstract | Aim: To investigate serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia (BPD) induced by intra-amniotic lipopolysaccharide (LPS) administration and postnatal hyperoxia (85%). Methods: We evaluated histological changes of the lungs and compared the levels of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), and protein carbonyl in lung tissue on days 1, 7, and 14 after birth in a rat model of BPD. Results: The inhibition of alveolarization was sustained in the LPS plus hyperoxia group from day 7 to 14, whereas alveolarization resumed in the hyperoxia group after oxygen exposure was withdrawn at day 7. Administration of LPS alone did not adversely affect lung morphometry. IL-6 levels showed transient overexpression at day 1 in the LPS-treated groups, but decreased at days 7 and 14. VEGF protein levels were elevated in the LPS-treated groups, but not in the hyperoxia and control groups at days 1, 7, and 14. Exposure to hyperoxia affected protein carbonyl levels in the hyperoxia group at days 7 and 14. Conclusion: Lung injury induced by intra-amniotic inflammation and postnatal hyperoxia may be due to inhibition of alveolarization without recovery even after withdrawal of oxygen. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WALTER DE GRUYTER & CO | ko_KR |
dc.subject | Bronchopulmonary dysplasia | ko_KR |
dc.subject | chorioamnionitis | ko_KR |
dc.subject | interleukin-6 | ko_KR |
dc.subject | vascular endothelial growth factor | ko_KR |
dc.subject | protein carbonyl | ko_KR |
dc.title | Serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia induced by intra-amniotic lipopolysaccharide and postnatal hyperoxia | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이현주 | - |
dc.contributor.AlternativeAuthor | 최창원 | - |
dc.contributor.AlternativeAuthor | 김병일 | - |
dc.contributor.AlternativeAuthor | 김이경 | - |
dc.contributor.AlternativeAuthor | 김한석 | - |
dc.contributor.AlternativeAuthor | 최정환 | - |
dc.contributor.AlternativeAuthor | 이명진 | - |
dc.contributor.AlternativeAuthor | 양은경 | - |
dc.identifier.doi | 10.1515/JPM.2010.091 | - |
dc.citation.journaltitle | JOURNAL OF PERINATAL MEDICINE | - |
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dc.description.tc | 0 | - |
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