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Antituberculosis drug-induced liver injury in chronic hepatitis and cirrhosis

Cited 19 time in Web of Science Cited 20 time in Scopus
Authors
Park, Wan Beom; Kim, Won; Lee, Kook Lae; Yim, Jae-Joon; Jung, Yong Jin; Kim, Dong Hee; Yoon, Jung-Hwan; Lee, Hyo Suk; Oh, Myoung-don; Kim, Yoon Jun; Kim, Nam Joong; Kim, Moonsuk
Issue Date
2010-10
Publisher
W B SAUNDERS CO LTD
Citation
JOURNAL OF INFECTION; Vol.61 4; 323-329
Keywords
TuberculosisChronic hepatitisLiver diseaseCirrhosisDrug toxicity
Abstract
Objectives: To evaluate the incidence, risk factors and outcomes for anti-tuberculosis (TB) drug-induced liver injury (DILI) in patients with chronic liver disease including cirrhosis. Methods: A total of 107 patients with chronic liver disease were assessed for anti-TB DILI. Anti-TB DILI was defined as elevation of alkaline phosphatase (ALP), aspartate transaminase, or alanine transaminase, or an increase in Child-Turcotte-Pugh score within 2 months of initiating anti-TB medication. The risk factors for anti-TB DILI were evaluated by multivariate logistic regression analysis. Results: Fifty-eight (54%) patients had cirrhosis. Of 93 patients receiving one or more hepatotoxic anti-TB drugs, 18 (17%) experienced DILI: 11 (24%) among 46 patients with chronic hepatitis and 7 (15%) among 46 patients with compensated liver cirrhosis (P = 0.271). Independent risk factors for DILI were female sex, number of hepatotoxic anti-TB drugs administered and baseline ALP levels but not cirrhosis itself. Of the 18 patients with DILI, 13 (72%) successfully completed anti-TB treatment after switching to less hepatotoxic drug regimens. Conclusions: Hepatotoxic anti-TB drugs may be safely used in the patients with chronic liver disease including compensated cirrhosis if number of hepatotoxic drugs used is adjusted appropriately. (C) 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
ISSN
0163-4453
Language
English
URI
http://hdl.handle.net/10371/77788
DOI
https://doi.org/10.1016/j.jinf.2010.07.009
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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