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Ninjurin1 mediates macrophage-induced programmed cell death during early ocular development
DC Field | Value | Language |
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dc.contributor.author | Lee, H-J | - |
dc.contributor.author | Ahn, B. J. | - |
dc.contributor.author | Shin, M. W. | - |
dc.contributor.author | Jeong, J-W | - |
dc.contributor.author | Kim, K-W | - |
dc.contributor.author | Kim, J. H. | - |
dc.date.accessioned | 2012-06-29T06:33:16Z | - |
dc.date.available | 2012-06-29T06:33:16Z | - |
dc.date.issued | 2009-10 | - |
dc.identifier.citation | CELL DEATH AND DIFFERENTIATION; Vol.16 10; 1395-1407 | ko_KR |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77963 | - |
dc.description.abstract | Developmental tissues go through regression, remodeling, and apoptosis. In these processes, macrophages phagocytize dead cells and induce apoptosis directly. In hyaloid vascular system (HVS), macrophages induce apoptosis of vascular endothelial cells (VECs) by cooperation between the Wnt and angiopoietin (Ang) pathways through cell-cell interaction. However, it remains unclear how macrophages are activated and interact with VECs. Here we show that Ninjurin1 (nerve injury-induced protein; Ninj1) was temporally increased in macrophages during regression of HVS and these Ninj1-expressing macrophages closely interacted with hyaloid VECs. Systemic neutralization using an anti-Ninj1 antibody resulted in the delay of HVS regression in vivo. We also found that Ninj1 increased cell-cell and cell-matrix adhesion of macrophages. Furthermore, Ninj1 stimulated the expression of Wnt7b in macrophages and the conditioned media from Ninj1-overexpressing macrophages (Ninj1-CM) decreased Ang1 and increased Ang2 in pericytes, which consequently switched hyaloid VEC fate from survival to death. Collectively, these findings suggest that macrophages express Ninj1 to increase the death signal through cell-cell interaction and raise the possibility that Ninj1 may act similarly in other developmental regression mediated by macrophages. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | NATURE PUBLISHING GROUP | ko_KR |
dc.subject | vascular biology | ko_KR |
dc.subject | cell adhesion | ko_KR |
dc.subject | macrophage | ko_KR |
dc.subject | Ninjurin1 | ko_KR |
dc.subject | apoptosis | ko_KR |
dc.title | Ninjurin1 mediates macrophage-induced programmed cell death during early ocular development | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1038/cdd.2009.78 | - |
dc.citation.journaltitle | CELL DEATH AND DIFFERENTIATION | - |
dc.description.citedreference | Yu WM, 2009, GLIA, V57, P850, DOI 10.1002/glia.20811 | - |
dc.description.citedreference | Santos AM, 2008, J COMP NEUROL, V506, P224, DOI 10.1002/cne.21538 | - |
dc.description.citedreference | Rao S, 2007, DEVELOPMENT, V134, P4449, DOI 10.1242/dev.012187 | - |
dc.description.citedreference | Alvarez Y, 2007, BMC DEV BIOL, V7, DOI 10.1186/1471-213X-7-114 | - |
dc.description.citedreference | Jakovcevski I, 2007, J NEUROSCI, V27, P7222, DOI 10.1523/JNEUROSCI.0739-07.2007 | - |
dc.description.citedreference | Liang CP, 2007, CIRC RES, V100, P1546, DOI 10.1161/CIRCRESAHA.107.152165 | - |
dc.description.citedreference | Jeong CH, 2007, J BIOL CHEM, V282, P13672, DOI 10.1074/jbc.M700534200 | - |
dc.description.citedreference | Remington LT, 2007, AM J PATHOL, V170, P1713, DOI 10.2353/ajpath.2007.060783 | - |
dc.description.citedreference | Rutland CS, 2007, MOL VIS, V13, P47 | - |
dc.description.citedreference | Zhang S, 2006, GENE DEV, V20, P1899, DOI 10.1101/gad.1426906 | - |
dc.description.citedreference | Lobov IB, 2005, NATURE, V437, P417, DOI 10.1038/nature03928 | - |
dc.description.citedreference | Zhan YM, 2005, J CLIN INVEST, V115, P2508, DOI 10.1172/JCI24403 | - |
dc.description.citedreference | Brown AS, 2005, INVEST OPHTH VIS SCI, V46, P2231, DOI 10.1167/iovs.04-0848 | - |
dc.description.citedreference | Hurskainen M, 2005, FASEB J, V19, P1564, DOI 10.1096/fj.04-3101fje | - |
dc.description.citedreference | Rosso SB, 2005, NAT NEUROSCI, V8, P34, DOI 10.1038/nn1374 | - |
dc.description.citedreference | Saint-Geniez M, 2004, INT J DEV BIOL, V48, P1045, DOI 10.1387/ijdb.041895ms | - |
dc.description.citedreference | Shui YB, 2003, INVEST OPHTH VIS SCI, V44, P3911, DOI 10.1167/iovs.02-1226 | - |
dc.description.citedreference | Willert K, 2003, NATURE, V423, P448, DOI 10.1038/nature01611 | - |
dc.description.citedreference | Affolter M, 2003, DEV CELL, V4, P11 | - |
dc.description.citedreference | Chambon JP, 2002, DEVELOPMENT, V129, P3105 | - |
dc.description.citedreference | Montero JA, 2001, DEVELOPMENT, V128, P2075 | - |
dc.description.citedreference | Kim JW, 2001, MOL CELLS, V11, P151 | - |
dc.description.citedreference | CHANG B, 2001, BMC GENET, V2, P18 | - |
dc.description.citedreference | Zhu MD, 2000, EXP EYE RES, V70, P767 | - |
dc.description.citedreference | Araki T, 2000, J NEUROSCI, V20, P187 | - |
dc.description.citedreference | De Angelis E, 1999, EMBO J, V18, P4744 | - |
dc.description.citedreference | Diez-Roux G, 1999, DEVELOPMENT, V126, P2141 | - |
dc.description.citedreference | Mitchell CA, 1998, DEV DYNAM, V213, P322 | - |
dc.description.citedreference | Ambili M, 1998, BBA-MOL CELL RES, V1403, P219 | - |
dc.description.citedreference | Reichel MB, 1998, CELL DEATH DIFFER, V5, P156 | - |
dc.description.citedreference | DiezRoux G, 1997, DEVELOPMENT, V124, P3633 | - |
dc.description.citedreference | Araki T, 1997, J BIOL CHEM, V272, P21373 | - |
dc.description.citedreference | Meeson A, 1996, DEVELOPMENT, V122, P3929 | - |
dc.description.citedreference | Araki T, 1996, NEURON, V17, P353 | - |
dc.description.citedreference | SUNDERKOTTER C, 1994, J LEUKOCYTE BIOL, V55, P410 | - |
dc.description.citedreference | LANG RA, 1993, CELL, V74, P453 | - |
dc.description.citedreference | MAURO VP, 1992, J CELL BIOL, V119, P191 | - |
dc.description.citedreference | COWAN WM, 1984, SCIENCE, V225, P1258 | - |
dc.description.citedreference | SCHLOSSHAUER B, 1984, NATURE, V310, P141 | - |
dc.description.tc | 5 | - |
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