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Transferrin induces interleukin-18 expression in chronic myeloid leukemia cell line, K-562

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Authors
Park, Sunyoung; Kim, Tae Sung; Kim, Cherlhyun; Kim, Seonghan; Park, Hyunjeong; Cho, Dae-Ho; Bang, Sa Ik
Issue Date
2009-02
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
LEUKEMIA RESEARCH; Vol.33 2; 315-320
Keywords
TransferrinLeukemiaApo-transferrinInterleukin-18 (IL-18)Proliferation
Abstract
Transferrin is an iron carrier protein involved in iron uptake and the regulation of cell growth. Although highly proliferative cells express transferrin and its receptor. little is known about the role of transferrin in the cellular response to cytokine production. The non-iron-bound form of transferrin (apo-transferrin) was administered to human chronic myeloid leukemia cell line, K-562 cells to assess Whether it could induce interleukin-18 (IL-18). Apo-transferrin enhanced IL-18 mRNA and protein and. moreover, IL-18 secretion was increased by treatment with apo-transferrin. In conclusion, apo-transferrin regulates IL-18 expression and we suggest that it is involved in cytokine production. (C) 2008 Elsevier Ltd. All rights reserved.
ISSN
0145-2126
Language
English
URI
http://hdl.handle.net/10371/78153
DOI
https://doi.org/10.1016/j.leukres.2008.08.001
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College of Medicine/School of Medicine (의과대학/대학원)Pharmacology (약리학전공)Journal Papers (저널논문_약리학전공)
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