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BT-11 Improves Stress-Induced Memory Impairments Through Increment of Glucose Utilization and Total Neural Cell Adhesion Molecule Levels in Rat Brains
DC Field | Value | Language |
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dc.contributor.author | Shin, Ki Young | - |
dc.contributor.author | Won, Beom Young | - |
dc.contributor.author | Heo, Chaejeong | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Park, Cheol Hyoung | - |
dc.contributor.author | Kim, Hye-Sun | - |
dc.contributor.author | Lee, Hyung Gun | - |
dc.contributor.author | Cho, Zang-Hee | - |
dc.contributor.author | Suh, Yoo-Hun | - |
dc.contributor.author | Lee, Sang Hyung | - |
dc.contributor.author | Kim, Young-Bo | - |
dc.contributor.author | Kim, Seonghan | - |
dc.contributor.author | Jang, Dong-Pyo | - |
dc.date.accessioned | 2012-07-03T00:44:50Z | - |
dc.date.available | 2012-07-03T00:44:50Z | - |
dc.date.issued | 2009-01 | - |
dc.identifier.citation | JOURNAL OF NEUROSCIENCE RESEARCH; Vol.87 1; 260-268 | ko_KR |
dc.identifier.issn | 0360-4012 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78161 | - |
dc.description.abstract | In Oriental medicine, roots of Polygala tenuifolia Willde-now have been known to be an important herb that exhibits sedative effects in insomnia, palpitation with anxiety, restlessness, and disorientation in humans. We previously reported that BT-11, extracted from those roots, improved scopolamine-induced amnesia in rats and inhibited acetylcholinesterase activities in vitro. Therefore, we proposed that BT-11 could remedy stress-induced memory deficits in rats. In this study, the stress-induced memory impairments in rats were significantly reversed almost to the control level by BT-11 treatment. To seek an active component of BT-11 that plays an important role in antipsychotic effects, we compared BT-11 with 3,4,5-trimethoxycinnamic acid (TMCA), which is a constituent of those root extracts. However, the effects of TMCA were less or were not consistent with those of BT-11 in some of tests. In perticular, BT-11 reversed the stress-induced reduction of glucose utilization by [(18)fluorodeoxyglucose] FDG-PET and the levels of neural cell adhesion molecule (NCAM) in rat brains to the control levels, whereas TMCA did not. Therefore, BT-11 improved stress-induced memory impairments through increment of glucose utilization and total NCAM levels in rat brains. In conclusion, BT-11 may be strongly effective against stress-induced amnesia in rats, through the combined effects of TMCA and other active components of BT-11. (C) 2008 Wiley-Liss, Inc. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-LISS | ko_KR |
dc.subject | BT-11 | ko_KR |
dc.subject | memory | ko_KR |
dc.subject | stress | ko_KR |
dc.subject | 3,4,5-trimethoxycinnamic acid | ko_KR |
dc.subject | Polygala tenuifolia | ko_KR |
dc.title | BT-11 Improves Stress-Induced Memory Impairments Through Increment of Glucose Utilization and Total Neural Cell Adhesion Molecule Levels in Rat Brains | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 신기영 | - |
dc.contributor.AlternativeAuthor | 원범영 | - |
dc.contributor.AlternativeAuthor | 허채정 | - |
dc.contributor.AlternativeAuthor | 김희진 | - |
dc.contributor.AlternativeAuthor | 장동표 | - |
dc.contributor.AlternativeAuthor | 박철형 | - |
dc.contributor.AlternativeAuthor | 김성한 | - |
dc.contributor.AlternativeAuthor | 김혜선 | - |
dc.contributor.AlternativeAuthor | 김영보 | - |
dc.contributor.AlternativeAuthor | 이형군 | - |
dc.contributor.AlternativeAuthor | 이상형 | - |
dc.contributor.AlternativeAuthor | 조장희 | - |
dc.contributor.AlternativeAuthor | 서유헌 | - |
dc.identifier.doi | 10.1002/jnr.21834 | - |
dc.citation.journaltitle | JOURNAL OF NEUROSCIENCE RESEARCH | - |
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dc.description.tc | 15 | - |
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