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Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60
DC Field | Value | Language |
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dc.contributor.author | Ryu, Su Jeong | - |
dc.contributor.author | Jung, Kyung Min | - |
dc.contributor.author | Yoo, Hyun Seung | - |
dc.contributor.author | Kim, Tae Woo | - |
dc.contributor.author | Chang, Jun | - |
dc.contributor.author | Choi, Eun Young | - |
dc.contributor.author | Kim, Sol | - |
dc.date.accessioned | 2012-07-03T01:02:51Z | - |
dc.date.available | 2012-07-03T01:02:51Z | - |
dc.date.issued | 2009-04-30 | - |
dc.identifier.citation | BLOOD; Vol.113 18; 4273-4280 | ko_KR |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78166 | - |
dc.description.abstract | In contrast to previous notions of the help-independency of memory CD8 T cells during secondary expansion, here we show that CD4 help is indispensable for the re-expansion of once-helped memory CD8 T cells, using a hematopoietic cell-specific dominant minor histocompatibility (H) antigen, H60, as a model antigen. H60-specific memory CD8 T cells generated during a helped primary response vigorously expanded only when rechallenged under helped conditions. The help requirement for an optimal secondary response was confirmed by a reduction in peak size by CD4 depletion, and was reproduced after skin transplantation. Helpless conditions or noncognate separate help during the secondary response resulted in a significant reduction in the peak size and different response kinetics. Providing CD4 help again during a tertiary challenge restored robust memory expansion; however, the repeated deprivation of help further reduced clonal expansion. Adoptively transferred memory CD8 T cells did not proliferate in CD40L(-/-) hosts. In the CD40(-/-) hosts, marginal memory expansion was detected after priming with male H60 cells but was completely abolished by priming with peptide-loaded CD40(-/-) cells, suggesting the essential role of CD40 and CD40L in memory responses. These results provide insight into the control of minor H antigen-specific CD8 T-cell responses, to maximize the graft-versus-leukemia response. (Blood. 2009; 113: 4273-4280) | ko_KR |
dc.description.sponsorship | This study was supported by grants from the Korea Science and
Engineering Foundation (R01-2006-000-10 565-0) and Seoul National University Hospital (03-2005-030), and was performed under BK21 program of Korea. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER SOC HEMATOLOGY | ko_KR |
dc.title | Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60 | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 류수정 | - |
dc.contributor.AlternativeAuthor | 정경민 | - |
dc.contributor.AlternativeAuthor | 유현승 | - |
dc.contributor.AlternativeAuthor | 김태우 | - |
dc.contributor.AlternativeAuthor | 김솔 | - |
dc.contributor.AlternativeAuthor | 장준 | - |
dc.contributor.AlternativeAuthor | 최은영 | - |
dc.identifier.doi | 10.1182/blood-2008-09-181263 | - |
dc.citation.journaltitle | BLOOD | - |
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dc.description.tc | 12 | - |
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