SHERP

개 지방세포 유래의 중간엽 줄기세포의 종양형성시험
Tumorigenesis Study of Canine Adipose Derived-mesenchymal Stem Cell

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Authors
이은선; 권은아; 박정란; 강병철; 강경선; 조명행
Issue Date
2007-09
Publisher
한국독성학회
Citation
한국독성학회지
Keywords
Canine adipose derived mesenchymal stem cells; BALB/c nu mice; Tumorigenicy
Abstract
Several recent studies demonstrated the potential of bioengineering using stem cells in regenerative medicine. Adult mesenchymal stem cells (MSCs) have the pluripotency to differentiate into cells of mesodermal origin, i.e., bone, cartilage, adipose, and muscle cells; they, therefore, have many potential clinical applications. On the other hand, stem cells possess a self-renewal capability similar to cancer cells. For safety evaluation of MSCs, in this study, we tested tumorigenecity of canine adipose derived mesenchymal stem cells (cAD-MSCs) using Balb/c-nu mice. In this study, there were no changes in mortality, clinical signs, body weights and biochemical parameters of all animals treated. In addition, there were no significant changes between control and treated groups in autopsy findings. These results indicate that cAD-MSC has no tumorigenic potential under the condition in this study.
Language
Other
URI
http://hdl.handle.net/10371/782
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Student's Archives (학생저작물)Student's WorksGraduated, Researcher (석·박사, 연구생)
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