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15-Deoxy-Δ12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: Possible roles of iron and ROS : 15-Deoxy-delta(12,14)-prostaglandin J(2) upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS
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dc.contributor.author | Kim, Do-Hee | - |
dc.contributor.author | Kim, Jung-Hyun | - |
dc.contributor.author | Kim, Eun-Hee | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Cha, Young-Nam | - |
dc.contributor.author | Chung, Jin Ho | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2012-07-03T02:40:58Z | - |
dc.date.available | 2012-07-03T02:40:58Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2009-04 | - |
dc.identifier.citation | Carcinogenesis, Vol.30 No.4, pp.645-654 | - |
dc.identifier.issn | 0143-3334 | - |
dc.identifier.other | 2914 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78201 | - |
dc.description.abstract | Heme oxygenase-1 (HO-1) has recently been found to be involved in angiogenesis and metastasis. In this study, we investigated whether HO-1 could potentiate the metastatic potential of human breast cancer cells. Treatment of MCF-7 and MDA-MB-231 cells with 30 mu M of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) increased the expression of HO-1, which preceded the induction of matrix metalloproteinases (MMPs). The 15d-PGJ(2)-induced upregulation of MMP-1 was abrogated by the HO-1 inhibitor zinc protoporphyrin IX (ZnPP) as well as introduction of HO-1 short interfering RNA. In addition, HO-1 inducers, such as cobalt protoporphyrin IX and hemin, upregulated the expression of MMP-1. Overexpression of HO-1 in the MCF-7 cells caused the induction of MMP-1 expression. Treatment with the HO-1 inhibitor ZnPP abolished the migrative phenotype of 15d-PGJ(2)-treated MCF-7 cells. MCF-7 cells treated with 15d-PGJ(2) exhibited intracellular accumulation of reactive oxygen species (ROS) which was abolished by ZnPP. We hypothesize that excess iron, released as a consequence HO-1 activity induced by 15d-PGJ(2), is transiently available for the stimulation of intracellular ROS generation and subsequently MMP-1 expression. 15d-PGJ(2)-mediated upregulation of MMP-1 expression was blocked by the iron chelator desferrioxamine and the Fe2+-specific chelator 1,10-phenanthroline. The iron chelators as well as the antioxidant N-acetyl-L-cysteine abrogated ROS formation by 15d-PGJ(2). In conclusion, 15d-PGJ(2) upregulates MMP-1 expression via induction of HO-1 and subsequent production of iron capable of generating ROS, which may contribute to increased metastasis and invasiveness of the human breast cancer cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | ko_KR |
dc.publisher | Oxford University Press | - |
dc.title | 15-Deoxy-Δ12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: Possible roles of iron and ROS | - |
dc.title.alternative | 15-Deoxy-delta(12,14)-prostaglandin J(2) upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1093/carcin/bgp012 | - |
dc.citation.journaltitle | Carcinogenesis | - |
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dc.description.tc | 14 | - |
dc.identifier.wosid | 000264889100013 | - |
dc.identifier.scopusid | 2-s2.0-64349099334 | - |
dc.citation.endpage | 654 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 645 | - |
dc.citation.volume | 30 | - |
dc.identifier.sci | 000264889100013 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Chung, Jin Ho | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ELEVATED CYCLOOXYGENASE-2 EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATED RECEPTOR-GAMMA | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | COX-2 EXPRESSION | - |
dc.subject.keywordPlus | CARBON-MONOXIDE | - |
dc.subject.keywordPlus | MCF-7 CELLS | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
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