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Effects of neonatal MK-801 treatment on p70S6K-S6/eIF4B signal pathways and protein translation in the frontal cortex of the developing rat brain
DC Field | Value | Language |
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dc.contributor.author | Kim, Se Hyun | - |
dc.contributor.author | Park, Hong Geun | - |
dc.contributor.author | Kim, Han Soo | - |
dc.contributor.author | Ahn, Yong Min | - |
dc.contributor.author | Kim, Yong Sik | - |
dc.date.accessioned | 2012-07-03T04:29:22Z | - |
dc.date.available | 2012-07-03T04:29:22Z | - |
dc.date.issued | 2010-10 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY; Vol.13 9; 1233-1246 | ko_KR |
dc.identifier.issn | 1461-1457 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78211 | - |
dc.description.abstract | Systemic injections of MK-801, a selective NMDAR antagonist, into neonatal rats induces long-term neurochemical and behavioural changes. It has been suggested that these changes form the neurodevelopmental basis for schizophrenia-like behaviour in rats. In this study, 7-d-old rats were treated with MK-801, and their frontal cortices were examined to investigate the effects on p70S6K-S6 signal pathway and on protein translation, which play crucial roles in the neurodevelopmental process. MK-801, in doses of 0.5 and 1.0 mg/kg, induced a decrease in phosphorylation of p70S6K and its substrates, S6 and eIF4B, in the first 8 h, and no change at 24 and 48 h. These effects were more prominent after two injections of MK-801 than one. Decreased S6 phosphorylation by MK-801 was evident in the prefrontal, cingulate, and insular cortex. In two representative upstream p70S6K-S6 pathways related to ERK1/2 and Akt, changes in ERK1/2-p90RSK phosphorylation were accompanied by changes of p70S6K-S6. Although two MK-801 injections induced a dose-dependent decrease in phosphorylation of Akt and mTOR at 4 and 8 h, a single injection did not produce a significant effect. Protein synthesis rate, measured by [(3)H] leucine incorporation in frontal cortical tissue, was reduced until 24 h after two MK-801 (1.0 mg/kg) injections. In summary, this study found that neonatal MK-801 treatment induced dysregulation in the p70S6K-S6/eIF4B pathway and protein translation in the frontal cortex of the developing rat brain, which may suggest an important role of protein translation machinery in the MK-801 neurodevelopmental animal model of schizophrenia. | ko_KR |
dc.description.sponsorship | This research was supported by a grant (no. A060477)
from the Korea Health 21 R&D Project, Ministry of Health & Welfare, and by a grant (no. M103KV010013- 07K2201-01310) from the Brain Research Centre of the 21st Century Frontier Research Programme funded by the Ministry of Science and Technology, Republic of Korea. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | CAMBRIDGE UNIV PRESS | ko_KR |
dc.subject | Neurodevelopment | ko_KR |
dc.subject | N-methyl-D-aspartate receptor | ko_KR |
dc.subject | schizophrenia | ko_KR |
dc.subject | small ribosomal protein 6 | ko_KR |
dc.subject | protein synthesis | ko_KR |
dc.title | Effects of neonatal MK-801 treatment on p70S6K-S6/eIF4B signal pathways and protein translation in the frontal cortex of the developing rat brain | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김세현 | - |
dc.contributor.AlternativeAuthor | 박홍근 | - |
dc.contributor.AlternativeAuthor | 김한수 | - |
dc.contributor.AlternativeAuthor | 안용민 | - |
dc.contributor.AlternativeAuthor | 김용식 | - |
dc.identifier.doi | 10.1017/S1461145709991192 | - |
dc.citation.journaltitle | INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | - |
dc.description.citedreference | Uehara T, 2009, PSYCHOPHARMACOLOGY, V206, P623, DOI 10.1007/s00213-009-1527-2 | - |
dc.description.citedreference | Fatemi SH, 2009, SCHIZOPHRENIA BULL, V35, P528, DOI 10.1093/schbul/sbn187 | - |
dc.description.citedreference | Copp J, 2009, CANCER RES, V69, P1821, DOI 10.1158/0008-5472.CAN-08-3014 | - |
dc.description.citedreference | Costa-Mattioli M, 2009, NEURON, V61, P10, DOI 10.1016/j.neuron.2008.10.055 | - |
dc.description.citedreference | Wang CZ, 2008, NEUROPSYCHOPHARMACOL, V33, P2442, DOI 10.1038/sj.npp.1301647 | - |
dc.description.citedreference | Xia Y, 2008, J PHARMACOL EXP THER, V326, P838, DOI 10.1124/jpet.107.133272 | - |
dc.description.citedreference | Lei G, 2008, NEUROPSYCHOPHARMACOL, V33, P1343, DOI 10.1038/sj.npp.1301511 | - |
dc.description.citedreference | Yoon SC, 2008, NEUROSCI LETT, V434, P23, DOI 10.1016/j.neulet.2008.01.020 | - |
dc.description.citedreference | Anastasio NC, 2008, J NEUROCHEM, V104, P1210, DOI 10.1111/j.1471-4159.2007.05047.x | - |
dc.description.citedreference | Meyuhas O, 2008, INT REV CEL MOL BIO, V268, P1, DOI 10.1016/S1937-6448(08)00801-0 | - |
dc.description.citedreference | Sutton MA, 2007, NEURON, V55, P648, DOI 10.1016/j.neuron.2007.07.030 | - |
dc.description.citedreference | Bessard A, 2007, J CELL PHYSIOL, V212, P526, DOI 10.1002/jcp.21049 | - |
dc.description.citedreference | Abekawa T, 2007, PSYCHOPHARMACOLOGY, V192, P303, DOI 10.1007/s00213-007-0729-8 | - |
dc.description.citedreference | Seo MS, 2007, INT J NEUROPSYCHOPH, V10, P359, DOI 10.1017/S1461145706006869 | - |
dc.description.citedreference | Roux PP, 2007, J BIOL CHEM, V282, P14056, DOI 10.1074/jbc.M700906200 | - |
dc.description.citedreference | Proud CG, 2007, BIOCHEM J, V403, P217, DOI 10.1042/BJ20070024 | - |
dc.description.citedreference | DU BOIS TM, 2007, BRAIN RES REV, V53, P260 | - |
dc.description.citedreference | Jaworski J, 2006, MOL NEUROBIOL, V34, P205, DOI 10.1385/MN:34:3:205 | - |
dc.description.citedreference | Gong RM, 2006, NEUROREPORT, V17, P1575, DOI 10.1097/01.wnr.0000234742.42818.ff | - |
dc.description.citedreference | Ahn YM, 2006, INT J NEUROPSYCHOPH, V9, P451, DOI 10.1017/S1461145705005882 | - |
dc.description.citedreference | Gong R, 2006, J BIOL CHEM, V281, P18802, DOI 10.1074/jbc.M512524200 | - |
dc.description.citedreference | Ruvinsky I, 2006, TRENDS BIOCHEM SCI, V31, P342, DOI 10.1016/j.tibs.2006.04.003 | - |
dc.description.citedreference | Tome CML, 2006, NEUROSCIENCE, V141, P1351, DOI 10.1016/j.neuroscience.2006.05.019 | - |
dc.description.citedreference | Ahn YM, 2005, INT J NEUROPSYCHOPH, V8, P607, DOI 10.1017/S1461145705005353 | - |
dc.description.citedreference | Ruggero D, 2005, ONCOGENE, V24, P7426, DOI 10.1038/sj.onc.1209098 | - |
dc.description.citedreference | Chiang GG, 2005, J BIOL CHEM, V280, P25485, DOI 10.1074/jbc.M501707200 | - |
dc.description.citedreference | Wedzony K, 2005, J PHYSIOL PHARMACOL, V56, P205 | - |
dc.description.citedreference | Stefani MR, 2005, BIOL PSYCHIAT, V57, P433, DOI 10.1016/j.biopsych.2004.11.031 | - |
dc.description.citedreference | Parsa AT, 2004, TRENDS MOL MED, V10, P607, DOI 10.1016/j.molmed.2004.10.009 | - |
dc.description.citedreference | Mothe-Satney I, 2004, J BIOL CHEM, V279, P42628, DOI 10.1074/jbc.M405173200 | - |
dc.description.citedreference | Hansen HH, 2004, NEUROBIOL DIS, V16, P440, DOI 10.1016/j.nbd.2004.03.013 | - |
dc.description.citedreference | Jackson ME, 2004, P NATL ACAD SCI USA, V101, P8467, DOI 10.1073/pnas.0308455101 | - |
dc.description.citedreference | Raught B, 2004, EMBO J, V23, P1761, DOI 10.1038/sj.emboj.7600193 | - |
dc.description.citedreference | Pende M, 2004, MOL CELL BIOL, V24, P3112, DOI 10.1128/MCB.24.8.3112-3124.2004 | - |
dc.description.citedreference | Dzietko M, 2004, NEUROBIOL DIS, V15, P177, DOI 10.1016/j.nbd.2003.10.006 | - |
dc.description.citedreference | KELLEHER RJ III, 2004, NEURON, V44, P59 | - |
dc.description.citedreference | Harris LW, 2003, EUR J NEUROSCI, V18, P1706, DOI 10.1046/j.1460-9568.2003.02902.x | - |
dc.description.citedreference | Wiley JL, 2003, PROG NEURO-PSYCHOPH, V27, P867, DOI 10.1016/S0278-5846(03)00146-5 | - |
dc.description.citedreference | Takahata R, 2003, NEUROPSYCHOPHARMACOL, V28, P1117, DOI 10.1038/sj.npp.1300127 | - |
dc.description.citedreference | Wang XM, 2003, MOL CELL BIOL, V23, P1546, DOI 10.1128/MCB.23.5.1546-1557.2003 | - |
dc.description.citedreference | Sircar R, 2003, PHARMACOL BIOCHEM BE, V74, P943, DOI 10.1016/S0091-3057(03)00025-X | - |
dc.description.citedreference | Lorrain DS, 2003, NEUROSCIENCE, V117, P697, DOI 10.1016/S0306-4522(02)00652-8 | - |
dc.description.citedreference | Andersen SL, 2003, NEUROSCI BIOBEHAV R, V27, P3, DOI 10.1016/S0149-7634(03)00005-8 | - |
dc.description.citedreference | Ritter LM, 2002, DEV BRAIN RES, V139, P227, DOI 10.1016/S0165-3806(02)00572-2 | - |
dc.description.citedreference | Sutton G, 2002, J NEUROCHEM, V82, P1097, DOI 10.1046/j.1471-4159.2002.01031.x | - |
dc.description.citedreference | Lehman JA, 2002, BIOCHEM BIOPH RES CO, V293, P463, DOI 10.1016/S0006-291X(02)00238-3 | - |
dc.description.citedreference | Chandler LJ, 2001, J BIOL CHEM, V276, P2627, DOI 10.1074/jbc.M003390200 | - |
dc.description.citedreference | Clancy B, 2001, NEUROSCIENCE, V105, P7, DOI 10.1016/S0306-4522(01)00171-3 | - |
dc.description.citedreference | Greene R, 2001, HIPPOCAMPUS, V11, P569, DOI 10.1002/hipo.1072 | - |
dc.description.citedreference | ROGERS GW JR, 2001, J BIOL CHEM, V276, P30914 | - |
dc.description.citedreference | Sekulic A, 2000, CANCER RES, V60, P3504 | - |
dc.description.citedreference | Contestabile A, 2000, BRAIN RES REV, V32, P476, DOI 10.1016/S0165-0173(00)00018-7 | - |
dc.description.citedreference | Peterson RT, 2000, J BIOL CHEM, V275, P7416, DOI 10.1074/jbc.275.10.7416 | - |
dc.description.citedreference | Sircar R, 2000, INT J DEV NEUROSCI, V18, P121, DOI 10.1016/S0736-5748(99)00069-6 | - |
dc.description.citedreference | Dufner A, 1999, EXP CELL RES, V253, P100, DOI 10.1006/excr.1999.4683 | - |
dc.description.citedreference | Jentsch JD, 1999, NEUROPSYCHOPHARMACOL, V20, P201, DOI 10.1016/S0893-133X(98)00060-8 | - |
dc.description.citedreference | Ikonomidou C, 1999, SCIENCE, V283, P70, DOI 10.1126/science.283.5398.70 | - |
dc.description.citedreference | Nicoll RA, 1999, ANN NY ACAD SCI, V868, P515, DOI 10.1111/j.1749-6632.1999.tb11320.x | - |
dc.description.citedreference | Paxinos G, 1998, RAT BRAIN STEREOTACT | - |
dc.description.citedreference | Sircar R, 1998, ANN NY ACAD SCI, V844, P303, DOI 10.1111/j.1749-6632.1998.tb08244.x | - |
dc.description.citedreference | Breier A, 1997, AM J PSYCHIAT, V154, P805 | - |
dc.description.citedreference | Moghaddam B, 1997, J NEUROSCI, V17, P2921 | - |
dc.description.citedreference | OLNEY JW, 1995, ARCH GEN PSYCHIAT, V52, P998 | - |
dc.description.citedreference | PEARSON RB, 1995, EMBO J, V14, P5279 | - |
dc.description.citedreference | SUN Y, 1995, AM J PHYSIOL-REG I, V268, pR549 | - |
dc.description.citedreference | BURDA J, 1994, BIOCHEM J, V302, P335 | - |
dc.description.citedreference | KOMURO H, 1993, SCIENCE, V260, P95, DOI 10.1126/science.8096653 | - |
dc.description.citedreference | BRACHA HS, 1992, AM J PSYCHIAT, V149, P1355 | - |
dc.description.citedreference | MULLEN RJ, 1992, DEVELOPMENT, V116, P201 | - |
dc.description.citedreference | NYGARD O, 1990, EUR J BIOCHEM, V191, P1, DOI 10.1111/j.1432-1033.1990.tb19087.x | - |
dc.description.citedreference | MEDNICK SA, 1988, ARCH GEN PSYCHIAT, V45, P189 | - |
dc.description.citedreference | KUBISTA M, 1987, BIOCHEMISTRY-US, V26, P4545, DOI 10.1021/bi00388a057 | - |
dc.description.citedreference | COSGROVE JW, 1986, NEUROCHEM RES, V11, P1289, DOI 10.1007/BF00966123 | - |
dc.description.citedreference | FANDO JL, 1980, NEUROCHEM RES, V5, P197, DOI 10.1007/BF00964332 | - |
dc.description.citedreference | FANDO JL, 1980, NEUROCHEM RES, V5, P373, DOI 10.1007/BF00964226 | - |
dc.description.tc | 1 | - |
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