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NTA center dot Ni2+-Functionalized Quantum Dots for VAMP2 Labeling in Live Cells

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dc.contributor.authorYu, Mi Kyung-
dc.contributor.authorLee, Suho-
dc.contributor.authorChang, Sunghoe-
dc.contributor.authorJon, Sangyong-
dc.date.accessioned2012-07-03T04:50:46Z-
dc.date.available2012-07-03T04:50:46Z-
dc.date.issued2010-06-20-
dc.identifier.citationBULLETIN OF THE KOREAN CHEMICAL SOCIETY; Vol.31 6; 1474-1478ko_KR
dc.identifier.issn0253-2964-
dc.identifier.urihttps://hdl.handle.net/10371/78218-
dc.description.abstractAn efficient method for labeling individual proteins in live cells is required for investigations into biological mechanisms and cellular processes. Here we describe the preparation of small quantum dots (QDs) that target membrane surface proteins bearing a hexahistidine-tag (His(6)-tag) via specific binding to an nitrilotriacetic acid complex of nickel(II) (NTA center dot Ni2+) on the QD surfaces. We showed that the NTA center dot Ni2+-QDs bound to His-tag functionalized beads as a cellular mimic with high specificity and that QDs successfully targeted His(6)-tagged vesicle-associated membrane proteins (VMAP) on cell surfaces. This strategy provides an efficient approach to monitoring synaptic protein dynamics in spatially restricted and confined biological environments.ko_KR
dc.description.sponsorshipThis work was supported by grants from
the Korea Science and Engineering Foundation (R01-2006-000-
10818-0) to S.C. funded by the Ministry of Education, Science
and Technology, Republic of Korea.		ko_KR
dc.language.isoenko_KR
dc.publisherKOREAN CHEMICAL SOCko_KR
dc.subjectQuantum dot conjugatesko_KR
dc.subjectImaging probesko_KR
dc.subjectProtein trackingko_KR
dc.subjectLabelingko_KR
dc.titleNTA center dot Ni2+-Functionalized Quantum Dots for VAMP2 Labeling in Live Cellsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor유미경-
dc.contributor.AlternativeAuthor이수호-
dc.contributor.AlternativeAuthor장성회-
dc.identifier.doi10.5012/bkcs.2010.31.6.1474-
dc.citation.journaltitleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
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