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Cancer screening using (18)F-FDG PET/CT in Korean asymptomatic volunteers: a preliminary report

Cited 28 time in Web of Science Cited 31 time in Scopus
Authors
Lee, Jeong Won; Kang, Keon Wook; Paeng, Jin Chul; Lee, Sang Mi; Chung, June-Key; Lee, Dong Soo; Lee, Myung Chul; Jang, Su Jin
Issue Date
2009-09
Publisher
SPRINGER
Citation
ANNALS OF NUCLEAR MEDICINE; Vol.23 7; 685-691
Keywords
(18)F-fluorodeoxyglucosePositron-emission tomographyCancer screening
Abstract
This study was performed to evaluate the clinical value of (18)F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/computed tomography (CT) for cancer screening in Korean asymptomatic people. Between February 2004 and December 2006, 1,587 asymptomatic individuals underwent FDG PET/CT as part of a cancer screening program with some other diagnostic tests at the healthcare center of our hospital. After excluding patients with a history of malignant tumor, 1,336 subjects were enrolled. All PET/CT images were visually analyzed. In subjects showing positive findings for PET/CT or other screening tests, further diagnostic tests and pathological confirmation were performed. Of the 1,336 subjects, malignant tumors were found in 16 participants (1.2%, thyroid cancer: 9, lung cancer: 2, stomach cancer: 2, and others: 4). There were 47 cases (3.6%) of positive PET/CT findings-11 cases were true positive (thyroid cancer: 8, lung cancer: 1, renal cancer: 1, and invasive thymoma), and 36 false positive, and five cases were false negative. The overall detection rate of PET/CT was 0.8%, and the sensitivity, specificity, positive-predictive value, and negative-predictive value of PET/CT were 68.8, 97.2, 23.4, and 99.6%, respectively. Fluorodeoxyglucose positron-emission tomography has the potential to detect various kinds of malignant tumors in cancer screening test, and the overall detection rate of PET/CT was 0.8%. FDG PET/CT can be a useful cancer screening modality with the selection of high-risk group and appropriate combination with other screening modalities.
ISSN
0914-7187
Language
English
URI
http://hdl.handle.net/10371/78278
DOI
https://doi.org/10.1007/s12149-009-0291-z
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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