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Feasibility of Template-Guided Attenuation Correction in Cat Brain PET Imaging

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dc.contributor.authorKim, Jin Su-
dc.contributor.authorLee, Jae Sung-
dc.contributor.authorPark, Min-Hyun-
dc.contributor.authorKim, Kyeong Min-
dc.contributor.authorCheon, Gi Jeong-
dc.contributor.authorMoon, Dae Hyuk-
dc.contributor.authorLee, Dong Soo-
dc.contributor.authorChung, June-Key-
dc.contributor.authorSong, In Chan-
dc.contributor.authorOh, Seung-Ha-
dc.date.accessioned2012-07-03T08:24:36Z-
dc.date.available2012-07-03T08:24:36Z-
dc.date.issued2010-06-
dc.identifier.citationMOLECULAR IMAGING AND BIOLOGY; Vol.12 3; 250-258ko_KR
dc.identifier.issn1536-1632-
dc.identifier.urihttp://hdl.handle.net/10371/78309-
dc.description.abstractPurpose: Attenuation correction (AC) is important in quantitative positron emission tomography (PET) imaging of medium-sized animals such as the cat. However, additional time for transmission (TX) scanning and tracer uptake is required in PET studies with animal-dedicated PET scanners because post-injection TX scanning is not available in these systems. The aim of this study was to validate a template-guided AC (TGAC) method that does not require TX PET data for AC in cat 2-deoxy-2-[F-(18)fluoro-D-glucose (FDG) brain PET imaging. Methods: PET scans were acquired using a microPET Focus 120 scanner. TX data were obtained using a (68)Ge point source before the injection of FDG. To generate the attention map (mu-map) template for the TGAC, a target image of emission (EM) PET was selected, and spatial normalization parameters of individual EM data onto the target were reapplied to the corresponding mu-maps. The inverse transformations of the mu-map template into the individual spaces were performed, and the transformed template was forward projected to generate the AC factor. The TGAC method was compared with measured AC (MAC) and calculated AC (CAC) methods using region of interest (ROI) and SPM analyses. Results: The ROI analysis showed that the activity of the TGAC EM PET images strongly correlated with those of the MAC data (y = 0.98x + 0.01, R(2)=0.96). In addition, no significant difference was observed in the SPM analysis. By contrast, the CAC showed a significantly higher uptake in the deep gray regions compared to the MAC (corrected P<0.05). The ROI correlation with MAC was worse than with the TGAC (R(2)=0.84). In SPM analysis for the voxel-wise group comparisons between before and after the induction of deafness, only the TGAC showed equivalent results with the MAC. Conclusions: The TGAC was reliable in cat FDG brain PET studies in terms of compatibility with the MAC method. The TGAC might be a useful option for increasing study throughput and decreasing the probability of subject movement. In addition, it might reduce the possible biological effects of long-term anesthesia on the cat brain in investigations using animal-dedicated PET scanners.ko_KR
dc.description.sponsorshipThis work was supported by grants from the
World Class University Program (R32-10142), Atomic Energy R&D
Program (2008-03852), Basic Atomic Energy Research Institute
Program (M20508050002-05B0805-00210, 2008-02334), Nuclear
R&D Program (M20702010002-08N0201-00200, 20090078289), and
Brain Research Center of the 21st Century Frontier Research Program
(M103KV010014-04K2201-01400) through the Korea Science and Engineering
Foundation funded by the Ministry of Education, Science and Technology.
ko_KR
dc.language.isoenko_KR
dc.publisherSPRINGERko_KR
dc.subjectAttenuation correctionko_KR
dc.subjectBrainko_KR
dc.subjectCatko_KR
dc.subjectSpatial normalizationko_KR
dc.subjectAnimal PETko_KR
dc.titleFeasibility of Template-Guided Attenuation Correction in Cat Brain PET Imagingko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김진수-
dc.contributor.AlternativeAuthor이재성-
dc.contributor.AlternativeAuthor박민현-
dc.contributor.AlternativeAuthor김경민-
dc.contributor.AlternativeAuthor오승하-
dc.contributor.AlternativeAuthor천지영-
dc.contributor.AlternativeAuthor송인찬-
dc.contributor.AlternativeAuthor문대혁-
dc.contributor.AlternativeAuthor정준기-
dc.contributor.AlternativeAuthor이동수-
dc.identifier.doi10.1007/s11307-009-0277-1-
dc.citation.journaltitleMOLECULAR IMAGING AND BIOLOGY-
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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