Publications
Detailed Information
Activation of toll-like receptors 2, 3 or 5 induces matrix metalloproteinase-1 and-9 expression with the involvement of MAPKs and NF-κB in human epidermal keratinocytes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Youngae | - |
dc.contributor.author | Kim, Hyunjung | - |
dc.contributor.author | Kim, Sangmin | - |
dc.contributor.author | Kim, Kyu Han | - |
dc.contributor.author | Chung, Jin Ho | - |
dc.date.accessioned | 2012-07-04T00:25:02Z | - |
dc.date.available | 2012-07-04T00:25:02Z | - |
dc.date.issued | 2010-08 | - |
dc.identifier.citation | EXPERIMENTAL DERMATOLOGY; Vol.19(8); E44-E49 | ko_KR |
dc.identifier.issn | 0906-6705 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78337 | - |
dc.description.abstract | Toll-like receptors (TLRs) on epidermal keratinocytes are the first line of defense against microbe invasion, and matrix metalloproteases (MMPs) regulate inflammation, cell migration and wound healing. In this study, we demonstrate that the mRNA and protein expressions of MMP-1 and MMP-9 in human epidermal keratinocytes are induced by ligands for TLR2, TLR3 and TLR5 [Pam3CSK4, Poly(I:C) and flagellin, respectively] in a dose-dependent manner. We also found that the ligands for TLR2, TLR3 and TLR5 activate the MAP kinases, JNK and p38 MAPK, but not ERK1/2. Furthermore, treatment with the ligands for TLR2, TLR3 and TLR5 also induced the degradation of I kappa B-alpha and activated the nuclear translocation of NF-kappa B. MMP-1 induction by the ligands for TLR2, TLR3 and TLR5 was inhibited by pretreatment with BAY11-7082 (NF-kappa B inhibitor) or SP600125 (JNK inhibitor), whereas MMP-9 expression was inhibited by pretreatment with BAY11-7082, SP600125 or SB203580. These findings demonstrate that the activation of TLR2, TLR3 or TLR5 induces the expression of MMP-1 and MMP-9 in human epidermal keratinocytes. In addition, NF-kappa B or JNK mediated the MMP-1 expression induced by TLR2, TLR3 and TLR5, whereas NF-kappa B, JNK or p38 MAPK mediated the MMP-9 expression induced by TLR2, TLR3 and TLR5. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-BLACKWELL | ko_KR |
dc.subject | keratinocytes | ko_KR |
dc.subject | toll-like receptors | ko_KR |
dc.subject | matrix metalloproteinase-1 | ko_KR |
dc.subject | matrix metalloproteinase-9 | ko_KR |
dc.title | Activation of toll-like receptors 2, 3 or 5 induces matrix metalloproteinase-1 and-9 expression with the involvement of MAPKs and NF-κB in human epidermal keratinocytes | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이영애 | - |
dc.contributor.AlternativeAuthor | 김현중 | - |
dc.contributor.AlternativeAuthor | 김상민 | - |
dc.contributor.AlternativeAuthor | 김규한 | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
dc.identifier.doi | 10.1111/j.1600-0625.2009.00963.x | - |
dc.citation.journaltitle | EXPERIMENTAL DERMATOLOGY | - |
dc.description.citedreference | Lee YM, 2008, EXP DERMATOL, V17, P864, DOI 10.1111/j.1600-0625.2008.00738.x | - |
dc.description.citedreference | Liang KC, 2007, J CELL PHYSIOL, V211, P759, DOI 10.1002/jcp.20992 | - |
dc.description.citedreference | Lim EJ, 2007, EXP MOL MED, V39, P239 | - |
dc.description.citedreference | Lebre MC, 2007, J INVEST DERMATOL, V127, P331, DOI 10.1038/sj.jid.5700530 | - |
dc.description.citedreference | Lee MS, 2007, ANNU REV BIOCHEM, V76, P447, DOI 10.1146/annurev.biochem.76.060605.122847 | - |
dc.description.citedreference | Kawai T, 2006, CELL DEATH DIFFER, V13, P816, DOI 10.1038/sj.cdd.4401850 | - |
dc.description.citedreference | Krueger S, 2006, J BIOL CHEM, V281, P2868, DOI 10.1074/jbc.m511053200 | - |
dc.description.citedreference | O`Neill LAJ, 2006, CURR OPIN IMMUNOL, V18, P3, DOI 10.1016/j.coi.2005.11.012 | - |
dc.description.citedreference | West AP, 2006, ANNU REV CELL DEV BI, V22, P409, DOI 10.1146/annurev.cellbio.21.122303.115827 | - |
dc.description.citedreference | Tanaka K, 2005, J PHARMACOL EXP THER, V315, P624, DOI 10.1124/jpet.105.088674 | - |
dc.description.citedreference | Lu YB, 2005, J IMMUNOL, V175, P5423 | - |
dc.description.citedreference | Borregaard N, 2005, J LEUKOCYTE BIOL, V77, P439, DOI 10.1189/jlb.0704381 | - |
dc.description.citedreference | Kida Y, 2005, CYTOKINE, V29, P159, DOI 10.1016/j.cyto.2004.10.009 | - |
dc.description.citedreference | RITTER M, 2005, J INFLAMM-LOND, V2, P16 | - |
dc.description.citedreference | Akira S, 2004, NAT REV IMMUNOL, V4, P499, DOI 10.1038/nri1391 | - |
dc.description.citedreference | Hogan RJ, 2004, INFECT IMMUN, V72, P1843, DOI 10.1128/IAI.72.4.1843-1855.2004 | - |
dc.description.citedreference | Jiang ZF, 2004, P NATL ACAD SCI USA, V101, P3533, DOI 10.1073/pnas.0308496101 | - |
dc.description.citedreference | McMillan SJ, 2004, J IMMUNOL, V172, P2586 | - |
dc.description.citedreference | Mempel M, 2003, J INVEST DERMATOL, V121, P1389 | - |
dc.description.citedreference | Yamamoto M, 2003, NAT IMMUNOL, V4, P1144, DOI 10.1038/ni986 | - |
dc.description.citedreference | de Lara LGV, 2003, AM J PHYSIOL-LUNG C, V285, pL899, DOI 10.1152/ajplung.00082.2003 | - |
dc.description.citedreference | Yamamoto M, 2003, SCIENCE, V301, P640, DOI 10.1126/science.1087262 | - |
dc.description.citedreference | Baker BS, 2003, BRIT J DERMATOL, V148, P670 | - |
dc.description.citedreference | Endo H, 2003, ARCH DERMATOL RES, V294, P552, DOI 10.1007/s00403-002-0364-5 | - |
dc.description.citedreference | Takeda K, 2003, ANNU REV IMMUNOL, V21, P335, DOI 10.1146/annurev.immunol.21.120601.141126 | - |
dc.description.citedreference | Kawai K, 2002, J DERMATOL SCI, V30, P185 | - |
dc.description.citedreference | Esteve PO, 2002, J BIOL CHEM, V277, P35150, DOI 10.1074/jbc.M108600200 | - |
dc.description.citedreference | Song PI, 2002, J INVEST DERMATOL, V119, P424 | - |
dc.description.citedreference | Ratzinger G, 2002, J IMMUNOL, V168, P4361 | - |
dc.description.citedreference | Lee CG, 2001, J EXP MED, V194, P809 | - |
dc.description.citedreference | Westermarck J, 1998, MATRIX BIOL, V17, P547 | - |
dc.description.citedreference | Kahari VM, 1997, EXP DERMATOL, V6, P199 | - |
dc.description.citedreference | Pilcher BK, 1997, J CELL BIOL, V137, P1445 | - |
dc.description.citedreference | SAARIALHOKERE UK, 1995, J INVEST DERMATOL, V105, P190 | - |
dc.description.tc | 8 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.