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UV decreases the synthesis of free fatty acids and triglycerides in the epidermis of human skin in vivo, contributing to development of skin photoaging
DC Field | Value | Language |
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dc.contributor.author | Kim, Eun Ju | - |
dc.contributor.author | Jin, Xing-Ji | - |
dc.contributor.author | Kim, Yeon Kyung | - |
dc.contributor.author | Oh, In Kyung | - |
dc.contributor.author | Park, Chi-Hyun | - |
dc.contributor.author | Chung, Jin Ho | - |
dc.contributor.author | Kim, Ji Eun | - |
dc.date.accessioned | 2012-07-04T01:12:34Z | - |
dc.date.available | 2012-07-04T01:12:34Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | JOURNAL OF DERMATOLOGICAL SCIENCE; Vol.57 1; 19-26 | ko_KR |
dc.identifier.issn | 0923-1811 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78356 | - |
dc.description.abstract | Background: Although fatty acids are known to be important in various skin functions, their roles on photoaging in human skin are poorly understood. Objective: We investigated the alteration of lipid metabolism in the epidermis by photoaging and acute UV irradiation in human skin. Methods: UV irradiated young volunteers (21-33 years, n = 6) and elderly volunteers (70-75 years, n = 7) skin samples were obtained by punch biopsy. Then the epidermis was separated from dermis and lipid metabolism was investigated. Results: We observed that the amounts of free fatty acids (FFA) and triglycerides (TG) in the epidermis of photoaged or acutely UV irradiated human skin were significantly decreased. The expressions of genes related to lipid synthesis, including acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase (SCD), sterol regulatory element binding proteins (SREBPs), and peroxisome proliferator-activated receptors (PPAR gamma) were also markedly decreased. To elucidate the significance of these changes of epidermal lipids in human skin, we investigated the effects of TG or various inhibitors for the enzymes involved in TG synthesis on the expression of matrix metalloproteinase-1 (MMP-1) in cultured human epidermal keratinocytes. We demonstrated that triolein (TG) reduced basal and UV-induced MMP-1 mRNA expression. In addition, each inhibitor for various lipid synthesis enzymes, such as TOFA (ACC inhibitor), cerulenin (FAS inhibitor) and trans-10, cis-12-CLA (SCD inhibitor), increased the MMP-1 expression significantly in a dose-dependent manner. We also demonstrated that triolein could inhibit cerulenin-induced MMP-1 expression. Furthermore, topical application of triolein (10%) significantly prevented UV-induced MMP-13, COX-2, and IL-1 beta expression in hairless mice. Conclusion: Our results suggest that TG and FFA may play important roles in photoaging of human skin. (C) 2009 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved. | ko_KR |
dc.description.sponsorship | This study was supported by a grant of the Korea Health 21 R&D
Project, Ministry of Health & Welfare, the Republic of Korea (A060160) and by a research agreement with AMOREPACIFIC Corporation. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER IRELAND LTD | ko_KR |
dc.subject | Ultraviolet radiation | ko_KR |
dc.subject | Free fatty acids | ko_KR |
dc.subject | Sterol regulatory element binding proteins | ko_KR |
dc.subject | Matrix metalloproteinase-1 | ko_KR |
dc.subject | Triglycerides | ko_KR |
dc.title | UV decreases the synthesis of free fatty acids and triglycerides in the epidermis of human skin in vivo, contributing to development of skin photoaging | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김은주 | - |
dc.contributor.AlternativeAuthor | 김연경 | - |
dc.contributor.AlternativeAuthor | 오인경 | - |
dc.contributor.AlternativeAuthor | 김지은 | - |
dc.contributor.AlternativeAuthor | 박치현 | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
dc.identifier.doi | 10.1016/j.jdermsci.2009.10.008 | - |
dc.citation.journaltitle | JOURNAL OF DERMATOLOGICAL SCIENCE | - |
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dc.description.tc | 1 | - |
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